endoplasmic reticulum-associated degradation
Endoplasmic Reticulum-Associated Degradation Is Required for Cold Adaptation and Regulation of Sterol Biosynthesis in the Yeast Saccharomyces cerevisiae
... Endoplasmic reticulum-associated degradation (ERAD) mediates the turnover of short-lived and misfolded proteins in the ER membrane or ...been associated with defects in ...improper ...
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Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO
... the endoplasmic reticulum-associated degradation (ERAD) pathway and that UL148, a viral factor that regulates HCMV cell tropism, in- teracts with the ERAD machinery and slows gO ...
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Rheumatoid arthritis as a hyper endoplasmic reticulum associated degradation disease
... this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the ER-associated degradation (ERAD) system, an essential system for ER ...
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Promotion of Endoplasmic Reticulum-Associated Degradation of Procathepsin D by Human Herpesvirus 8-Encoded Viral Interleukin-6
... pression, processing, and activities of CatD, notably as a proapo- ptotic protein released from lysosomes under conditions of stress and as a secreted promitogenic factor (pCatD) in cancer (e.g., references 31 to 37). ...
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Effects of a Defective Endoplasmic Reticulum-Associated Degradation Pathway on the Stress Response, Virulence, and Antifungal Drug Susceptibility of the Mold Pathogen Aspergillus fumigatus
... In this study, we demonstrate that deletion of HrdA in A. fumiga- tus reduces the ability of the fungus to degrade the ERAD substrate CPY*, and potentially many other proteins that fail to accurately fold in the ER ...
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Epigenetic loss of the endoplasmic reticulum–associated degradation inhibitor SVIP induces cancer cell metabolic reprogramming
... their degradation by the ubiquitin-proteasome system (UPS) ...stress associated with antitumor activity (7–9), even in cancer models where proteasome inhibitors are inactive (7), a finding that prompted ...
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Endoplasmic reticulum degradation–enhancing α mannosidase–like protein 1 targets misfolded HLA–B27 dimers for endoplasmic reticulum–associated degradation
... predominantly associated as a dimer with EDEM1, whilst C164S demonstrated an altered dimeric conformation, but could associate with EDEM1 both as a monomer and dimer ...
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Endoplasmic Reticulum Degradation Enhancing α Mannosidase like Protein 1 Targets Misfolded HLA B27 Dimers for Endoplasmic Reticulum Associated Degradation
... the associated inflammatory diseases then they could be targeted for therapeutic intervention in a manner similar to other protein conformational ...the degradation of HLA-B27 dimers and that this pathway ...
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Reduction of HIV-1 Infectivity through Endoplasmic Reticulum-Associated Degradation-Mediated Env Depletion
... ticles as measured by retrotranscriptase units (12) (corresponding to 30 ng of p24) and tested for luciferase activity after 48 h. All the gp160-specific degradins showed a strong reduction in viral infec- tivity ...
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Role of Cell-Type-Specific Endoplasmic Reticulum-Associated Degradation in Polyomavirus Trafficking
... the endoplasmic reticu- lum (ER) for productive infection to occur; however, it is unknown how BKPyV exits the ER before nuclear ...ER-associated degradation (ERAD) pathway during BKPyV intracellular ...
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Metformin promotes antitumor immunity via endoplasmic-reticulum-associated degradation of PD-L1
... We identified S195-p of PD-L1 as a critical event that determines whether it is transported to the membrane or degraded by ERAD. In addition, we identified HRD1 as an ERAD E3 ligase of PD-L1 (Figure 4I, 4J and S4F), ...
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Original Article Endoplasmic reticulum stress associated apoptosis implicated in atrial fibrillation
... tion factor to regulate the ER-associated degra- dation (ERAD) proteins to decrease the misfold- ed protein synthesis [8]. The second ER stress branch involves IRE1 and X-box-binding protein 1 (XBP1). Activated ...
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Human Cytomegalovirus Inhibits Apoptosis by Proteasome-Mediated Degradation of Bax at Endoplasmic Reticulum-Mitochondrion Contacts
... tosome components. DRMs were isolated from HFFs transfected with vMIA wt or the cholesterol binding mutants, CBD I and II (Fig. 7B). Cyt c, Bid, Apaf1, and procaspase 9 were weakly detected in lipid rafts from ...
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Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis
... events associated with cytoplasmic vesicle formation, which, in turn, was related to ER stress-induced ...autophagosome-lysosome degradation as Atg9b-driven phagophores may facilitate docking of both LC3 ...
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Endoplasmic reticulum stress in lung disease
... for degradation by the ubiquitin proteasome system. This ER-associated degradation is augmented by the UPR and is responsible for the continued removal of mutated secretory proteins from the ...
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Mutant Membrane Protein of the Budding Yeast Spindle Pole Body Is Targeted to the Endoplasmic Reticulum Degradation Pathway
... (Vallen et al. 1992; Pereira et al. 2001). The newly Interestingly, MPS2 was also isolated in a screen for formed SPB, or duplication plaque, is assembled next genes that were toxic when overexpressed in cells har- to ...
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Hepatitis C Virus F Protein Is a Short-Lived Protein Associated with the Endoplasmic Reticulum
... To understand the molecular mechanism that is responsible for the instability of the F protein, serine protease inhibitors, including leupeptin, aprotinin, and Pefabloc, were added into the translation mixture at the ...
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Role of Endoplasmic Reticulum in Non-communicable Diseases
... There are two distinct types of ER that differ in structure and function: smooth ER and rough ER. The rough ER is so named because the cytoplasmic surface is covered with ribosomes. The smooth ER appears smooth since its ...
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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours
... when associated with nevoid basal cell carcinoma syndrome “NBCCS” or Gorlin-Goltz syndrome, the recurrence rate is about 82% ...The endoplasmic reticulum (ER) is an organelle with a major role in the ...
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The Mitochondrial Translocator Protein, TSPO, Inhibits HIV-1 Envelope Glycoprotein Biosynthesis via the Endoplasmic Reticulum-Associated Protein Degradation Pathway
... Although it is well known that Env proteins are folded in the ER, the precise mechanism of this process is still unclear. Because TSPO overexpression could influence Env folding, it suggests that mitochondria could play ...
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