Endoplasmic reticulum-mediated apoptosis
Endoplasmic reticulum stress-mediated upregulation of miR-29a enhances sensitivity to neuronal apoptosis.
... of apoptosis signalling cascade by activating Bax and ...induced apoptosis in neural cells and identified the BH3-only protein, Puma, as an essential, stress-induced mediator of apoptosis within this ...
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Human Cytomegalovirus Inhibits Apoptosis by Proteasome-Mediated Degradation of Bax at Endoplasmic Reticulum-Mitochondrion Contacts
... Our current model is that HCMV vMIA recruits Bax to the MAM and then targets it for proteasome-mediated degradation. However, steadily increasing Bax levels, which occur during infec- tion, overwhelm the MAM ...
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Glycolaldehyde induces endoplasmic reticulum stress and apoptosis in Schwann cells
... of apoptosis [15] ...induce apoptosis via oxidative stress [7,8,11] ...causes apoptosis or ...induces apoptosis via oxida- tive stress in breast cancer cells [16] .... Endoplasmic ...
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Original Article Endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsis-induced liver injury
... Abstract: Endoplasmic reticulum (ER) stress has been increasingly recognized to have an important role in various liver ...analysis. Apoptosis was detected via terminal deoxynucleotidyl transfer- ase ...
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Fibroblast Growth Factor 21 Attenuates Vascular Calcification by Alleviating Endoplasmic Reticulum Stress Mediated Apoptosis in Rats
... expression can protect tissues and organs against the adverse effects induced by ERS. In our study, administration of FGF21 in turn ameliorated the ERS responses of VC by suppressing CHOP and caspase- 12 pathways. These ...
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Dapagliflozin rescues endoplasmic reticulum stress mediated cell death
... suppresses apoptosis via regulation of the elf2 α -ATF4-CHOP ...and apoptosis, whereas it activates the IRE1-XBP1 and ATF6 pathways 44 ...and apoptosis vary with the nature of cells and/or ...
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Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
... and apoptosis in human breast cancer cells (MDA-MB-231 and ...is mediated, at least in part, by a specific binding and activation of the estrogen receptor- β (ER β ...to apoptosis, also in tumor ...
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Inhibition of endoplasmic reticulum (ER) stress sensors sensitizes cancer stem-like cells to ER stress-mediated apoptosis
... When combined with IRE1i, 20 μM of cisplatin shifted sphere-forming cells to ER stress-mediated apoptosis. The results of the present study suggest that inhibitors of ER stress sensors have the ability to ...
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Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis
... cardiomyocyte apoptosis in response to ER stress after I/R injury. 13 CHOP- mediated apoptosis is involved in the downregulation of the anti-apoptotic protein Bcl-2, the upregulation of the ...
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α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes
... Cell viability and death were assessed as described pre- viously by measurement of the enzymatic conversion of the yellow tetrazolium salt 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) into purple ...
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Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes
... Increased long chain saturated fatty acids induce ER stress, activate the UPR and promote cell death in a great amount of cell types, such as hepatocytes [25][21] [4][26,27]. Thus, disruption in ER function seems lead to ...
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Endoplasmic reticulum–mitochondria crosstalk in NIX mediated murine cell death
... stimulates apoptosis (47). Cal- cium-mediated stimulation of cardiomyocyte apoptotic and nonapoptotic death pathways has the potential to complicate efforts to enhance cardiac contractility and treat heart ...
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Original Article Endoplasmic reticulum stress associated apoptosis implicated in atrial fibrillation
... It has been known that ER stress induced apop- tosis is mainly mediated by CHOP, which is Figure 2. Apoptosis rate in LAAs. A. DR5 mRNA expression in LAA normalized to GAPDH. B. Cleaved caspase 3 and ...
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Original Article Effect of HSP70 on cardiomyocyte apoptosis induced by endoplasmic reticulum stress
... and mediated by ER ...stress-induced apoptosis, flow cytometry was used to detect apoptosis rate of neonatal rat myocardial cells, western blot was applied to test the expression of Caspase-12, CHOP, ...
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Involvement of Endoplasmic Reticulum Stress in Myocardial Apoptosis of Streptozocin-Induced Diabetic Rats
... Summary Apoptosis plays critical role in diabetic cardiomyopathy and endoplasmic reticulum stress (ERS) is one of intrinsic apoptosis ...plasmic reticulum become swell in diabetic ...
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Endoplasmic reticulum stress is involved in myocardial apoptosis of streptozocin-induced diabetic rats
... Histopathology, TUNEL, and immunohistochemistry (IHC) staining After 2 days of echocardiographic evaluation, the rats were anesthetized again, their hearts removed and sliced transver- sely, and eight diabetic and five ...
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Chlorogenic acid against palmitic acid in endoplasmic reticulum stress-mediated apoptosis resulting in protective effect of primary rat hepatocytes
... (1) Endoplasmic reticulum stress and Lipotoxicity (supported by the basic research plan of natural science in Shaanxi province 2014JM2 – 3034); (2) Chlorogenic Acid and hepatic protection (project supported ...
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Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
... of apoptosis, we speculated that overload kills b cells as a result of endoplasmic reticulum (ER) ...stress–associated apoptosis factor Chop were induced in the ...to apoptosis via Chop ...
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Replication of a Cytopathic Strain of Bovine Viral Diarrhea Virus Activates PERK and Induces Endoplasmic Reticulum Stress-Mediated Apoptosis of MDBK Cells
... to apoptosis of the infected ...to apoptosis of the infected ...that apoptosis induced by Japanese encephalitis virus correlates with induction of an ER stress response ...
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Original Article Bortezomib induced autophagy to protect esophageal cancer cells from apoptosis through endoplasmic reticulum stress-mediated way
... cell apoptosis of EC cells, suggesting the anti-tumor effects of BZ for EC ...cell apoptosis, compared with the BZ treated group, while inhibition of autophagy by Chloroquine (CQ) treatment had the opposite ...
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