Endoplasmic Reticulum Stress
Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress
... reduced endoplasmic reticulum stress-mediated apoptosis in the presence of oxygen ...attenuating endoplasmic reticulum stress and oxidative stress in the early stage of ...
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Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas
... Ethanol-induced endoplasmic reticulum stress was demonstrated by a significant increase in ATF6, CHOP, and the phosphorylation of PERK and ...cellular stress to the pancreas, offering a good ...
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Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology
... The endoplasmic reticulum (ER) is a complex protein folding and trafficking ...the endoplasmic reticulum environment can affect the protein folding process and hence, can result in the ...
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Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells
... Background: We have previously reported that γ - and δ -tocotrienols ( γ - and δ -T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, ...
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Severe Burn-Induced Endoplasmic Reticulum Stress and Hepatic Damage in Mice
... ER stress and is associated with insulin resistance in pediatric burn patients (unpublished ...ER stress- signaling pathways may offer therapeu- tic benefits by improving organ function and patient survival ...
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Endoplasmic Reticulum Stress in Age-Related Macular Degeneration: Trigger for Neovascularization
... oxidative stress, which means that the efficiency of pro- teasomal degradation is impaired and misfolded proteins aggregate into cytosol ...ER stress, which acts through UPR signaling to stimulate the ...
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Endoplasmic reticulum stress and apoptosis
... In mitochondria-initiated apoptosis, BAX and BAK activation involves members of the BCL-2 family named BH3-only proteins. The presence of several BH3- only proteins, such as tBID, BIM, NOXA and PUMA, in the mitochondria ...
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Endoplasmic reticulum stress in the lung : lessons from α1-antitrypsin deficiency
... ER stress if exposed to a second insult (82, ...ER stress inducer tunicamycin or a more physiological glucose starvation, they show an exaggerated activation of the ATF6- luciferase reporter together with ...
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Original Article Effect of human protein kinase R-like endoplasmic reticulum kinase gene on the apoptosis of LO2 hepatocytes under endoplasmic reticulum stress
... ER stress-mediated apoptosis, PERK temporarily terminated protein synthesis and activated ATF4 to up-reg- ulate the expression of CHOP that inhibits Bcl-2 expression, finally leading to cell apopto- sis through ...
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Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema
... We also demonstrated that hemin (a form of heme) treatment increased ER stress in HBECs. There- fore, to determine if attenuating heme can be a therapeutic approach to ameliorate chronic lung compli- cations after ...
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LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma
... ER stress both in vitro and in vivo, which facilitated apoptosis of hepatocellular carcinoma ...ER stress accounted for lincRNA-p21 effects on apoptosis, proliferation and in vivo growth of hepatocellular ...
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Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis
... ER stress challenges, in- cluding through the induction of BiP, is severely compromised ...ER stress or a compromised UPR on disease onset and progression, ...ER stress is an early response in ...
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Endoplasmic reticulum stress in amelogenesis imperfecta and phenotypic rescue using 4-phenylbutyrate
... impairing endoplasmic reticulum (ER) trafficking, causing ER stress and triggering the unfolded protein response ...ER stress in the pathogenesis of this inherited conformational ...
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Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
... transmit stress signals in response to pertur- bation of protein ...ER stress transducer proteins, including Ire1 α and PERK, are expressed at high levels in β ...
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Endoplasmic Reticulum Stress and Neurodegeneration in Rats Neonatally Infected with Borna Disease Virus
... XBP1 splicing in NBD rats. ER stress results in Bip release from IRE1 and activation of IRE1 RNase activity. XBP1 mRNA serves as a specific substrate for IRE1 RNase (78). Thus, splicing of XBP1 is commonly used as ...
14
Original Article Endoplasmic reticulum stress associated apoptosis implicated in atrial fibrillation
... that endoplasmic reticulum (ER) stress could mediate apoptosis and play a role in tissue remodeling after ...ER stress and its association with apoptosis in AF ...ER stress mediators, ...
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Elevated urinary CRELD2 is associated with endoplasmic reticulum stress–mediated kidney disease
... ER stress, which will be helpful in the development of mechanism-based treatment in ischemic ...ER stress, an underlying causative mechanism for ischemic ...ER stress modulators before a detectable ...
20
Endoplasmic reticulum stress-induced autophagy determines the susceptibility of melanoma cells to dabrafenib
... both endoplasmic reticulum (ER) stress and autophagy were induced in the melanoma cells after the treatment with ...ER stress- induced autophagy protects melanoma cells from the toxicity of ...
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Original Article Effect of HSP70 on cardiomyocyte apoptosis induced by endoplasmic reticulum stress
... in endoplasmic reticulum (ER) stress-induced cell apoptosis, and to reveal the molecular mechanism underlying the HSP70 regulated ER stress induced-apoptosis, secretion and calci- um signal ...
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Taurine protection of PC12 cells against endoplasmic reticulum stress induced by oxidative stress
... (2010) [39] proposed that ROS can target ER-based cal- cium channels and chaperones, leading to the release of calcium from the ER to the cytosol. Increased cytosolic calcium can stimulate mitochondrial metabolism to ...
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