Endoplasmic reticulum stress response
Phagocytosis influences the intracellular survival of Mycobacterium smegmatis via the endoplasmic reticulum stress response
... ER stress-mediated apop- tosis ...ER stress response ...ER stress in macrophages infected with ...and endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), in ...ER stress ...
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Translational control in the endoplasmic reticulum stress response
... during stress are usually transient ...to stress resistance, as, in animal mod- els of ischemic stroke, it has been observed that trans- lation recovers in all but the most vulnerable areas of the brain ...
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Characterization of the nicotine-induced endoplasmic reticulum stress response in the rat placenta in vivo and in vitro
... protein response, which seeks to post-transcriptionally up-regulate their protein levels in the presence of ER stress, as seen in previous studies ...ER stress, it may be stipulated that the ...
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Coordination of the endoplasmic reticulum stress response and lipid metabolism in plants
... stress response. Two such compounds that are known to induce an ER stress response in yeast, animals and plants are tunicamycin (Tm) and azetidine 2-carboxylic acid ...ER stress ...
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Japanese Encephalitis Virus Infection Initiates Endoplasmic Reticulum Stress and an Unfolded Protein Response
... ER stress, whereas it is highly induced in JEV-infected cells, probably due to the large amount of viral glycoproteins accu- ...ER stress inducer in BHK-21 and N18 cells, and they also imply that the virus ...
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Endoplasmic reticulum stress in lung disease
... the endoplasmic reticulum ...ER stress ” . The cellular processes that defend against ER stress are collectively called the unfolded protein response (UPR) [2] (figure ...
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Endoplasmic reticulum stress and apoptosis
... overloaded response; ER – endoplasmic reticulum; GADD 153 – growth arrest and DNA damage; GCN2 – general control of amino acid biosynthesis kinase; GRPs – glucose-regulated protein family; GSK3β – ...
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Olmesartan, an AT1 Antagonist, Attenuates Oxidative Stress, Endoplasmic Reticulum Stress and Cardiac Inflammatory Mediators in Rats with Heart Failure Induced by Experimental Autoimmune Myocarditis
... plasmic reticulum (ER), suggesting that ER overload occurs in this condition ...Oxidative stress, hypox- ia, and enhanced protein synthesis in failing hearts could all potentially enhance ER ...ER ...
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Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
... in endoplasmic reticulum (ER) stress and activation of the unfolded protein response ...ER stress is associated with the development of degenerative and fibrotic disorders in multiple ...
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ATF6α regulates morphological changes associated with senescence in human fibroblasts
... Protein Response (UPR) is linked to ...three Endoplasmic Reticulum (ER) stress sensors (PERK, ATF6α and IRE1α) and aims at restoring ER homeostasis ...the stress is not resolved, the ...
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The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum
... ER stress by activating the inte- grated stress response ...to stress (44). Stress-regulated translation of such mRNAs involves small upstream open reading frames (uORFs) in their 5= ...
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Renal response to tunicamycin-induced endoplasmic reticulum stress in BDNF heterozygous mice
... in BDNF-deficient mice, the serum creatinine levels (an in- dicator for renal function) in these mice were not different from those of the WT+Tm group. Nevertheless, a negative correlation between renal BDNF expression ...
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The Endoplasmic Reticulum Stress Sensor Inositol Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production
... ER stress is modulated by several mechanisms ...ER stress but inhibited ROS production, suggest- ing that ROS production occurs subsequent to ER ...ER stress triggered by oxidized low-density ...
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The endoplasmic reticulum in plant immunity and cell death
... in response to TM (Kamauchi et ...ER stress alleviation, resulting in enhanced PCD in response to bacterial pathogens (Xu et ...ER stress but suppresses the adaptive UPR ...ER stress ...
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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
... ER stress, gene ontology analysis for biological function of the upregulated genes showed enrichment in genes linked to ER stress and the UPR (Table ...defense response, innate immune re- sponse, and ...
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Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics
... the endoplasmic reticulum (ER) stress/unfolded protein response (UPR) pathway in Jurkat and CEM-R cells as protective mechanisms in a sub-population of T-ALL ...and stress ...
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Identification and characterization of maize Derlins in response to endoplasmic reticulum stress
... dependent fashion. In Arabidopsis cells expressing a dominant-negative form of Cdc48, which is inactive in its ATPase domain, there was an increased accumulation of the mildew resistance O (MLO) substrate in the cell ...
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Targeting protein quality control pathways in breast cancer
... restores endoplasmic reticulum homeostasis [28, 30, ...PKR-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) branches [28, 140] ...the endoplasmic ...
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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours
... Among the various consequences of UPR is also the upregulation of BiP/GRP78 and of other chaperones that is considered diagnostic for the induction of ER stress in a given tissue [16-18]. BiP/GRP78 binds to the ...
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A comparative study of toxicity of TiO<sub>2</sub>, ZnO, and Ag nanoparticles to human aortic smooth-muscle cells
... TiO 2 , ZnO, and Ag NPs to HASMCs to understand the potential adverse vascular effects of these NPs on blood vessels. It was shown that only ZnO NPs significantly induced cytotoxicity in HASMCs, associated with an ...
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