Endothelial protein C receptor
Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
... Endothelial protein C receptor (EPCR) is an endothelial transmembrane glycoprotein able to bind to a natural anticoagulant, protein C (PC), and its activated form, APC, ...
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An early increase in endothelial protein C receptor is associated with excess mortality in pneumococcal pneumonia with septic shock in the ICU
... The protein C (PC) anticoagulant pathway is a major system that prevents coagulation, and its impairment influences outcome in ...and protein S, and two endothelial recep- tors: thrombomodulin ...
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Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania
... the endothelial protein C receptor (EPCR) has been identified as a specific recep- tor for the ...membrane protein 1 (PfEMP1) variants mediating sequestration of infected erythrocytes ...
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Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum Infected Erythrocytes to Endothelial Cells
... the endothelial protein C receptor (EPCR) are candidate receptors for the deadly complication cerebral ...membrane protein 1 (PfEMP1) family have dual binding specificity for EPCR and ...
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Relation between Endothelial Protein C Receptor Gene Polymorphisms rs867186 and rs9574, and the Risk of Deep Vein Thrombosis in Sudanese
... Background: Deep venous thrombosis (DVT) can lead to a serious fatal pulmonary embolism. Many genetic risk factors may predispose to DVT; one of these is the mutation in the PROCR gene responsible for the production of ...
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Association of the endothelial protein C receptor (PROCR) rs867186 G allele with protection from severe malaria
... whereas non-CD36 binding variants are encoded by some group A var genes [9,10]. Recently, the PfEMP1 subtypes containing domain cassettes (DCs) 8 (group B/A hybrid) and 13 (group A) are shown to mediate adherence of P. ...
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Relation between the Level of Soluble Endothelial Protein C Receptor and the Risk of Deep Venous Thrombosis in Sudanese
... In the present study DVT patients showed higher sEPCR level than in healthy individuals, this finding consistent with that stated by many studies [10] [11] [14]-[18]. In DVT patients there was a typically high production ...
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Identification of functional endothelial protein C receptor in human plasma
... protein C affinity column that had been prepared previously by ap- plying the purified protein C (3 mg) to an HPC4 AffiGel-10 column (5 mg IgG/ml resin; ...the protein C ...
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Expression and shedding of endothelial protein C receptor in prostate cancer cells
... sphingosine-1-phosphate receptor- 1 dependent manner ...at endothelial cell surfaces are mark- edly changed by its ectodomain cleavage and release in soluble form (sEPCR) ...
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Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria
... membrane protein 1 (PfEMP1) is considered a key virulence factor in malaria, as it binds to various host receptors on the endothelium or UEs (rosetting) to sequester infected erythrocytes from circulation and ...
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A prospective, randomised, placebo controlled, double masked, three armed, multicentre phase II/III trial for the Study of a Topical Treatment of Ischaemic Central Retinal Vein Occlusion to Prevent Neovascular Glaucoma – the STRONG study: study protocol for a randomised controlled trial
... (Soluble) endothelial protein C receptor; (SD-)OCT: (Spectral domain) optical coherence tomography; ANCOVA: Analysis of covariance; BCVA: Best-corrected visual acuity; BRVO: Branch retinal ...
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Pathogenicity Determinants of the Human Malaria Parasite Plasmodium falciparum Have Ancient Origins
... and C) and a placenta-specific E variant, as defined by the chromosomal location and 5= upstream sequence region ...and C) and endothelial protein C receptor (EPCR) binding (group ...
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The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth
... multiple protein-protein interactions and the scaffolding function of FAK plays a pivotal role in cancer cell signaling [19, ...specific protein-protein interactions of FAK demonstrate ...
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The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness
... multifunctional protein, with procoagulant, inflammatory and anticoagulant ...of Protein C and initiation of the Activated Protein C anticoagulant pathway, a process that is augmented ...
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The protein interacting with C kinase (PICK1) interacts with and attenuates parkin associated endothelial like (PAEL) receptor mediated cell deat
... The ct-PAELR interacts with the PDZ domain of PICK1 To determine the site of interaction in PICK1, the ct-PAELR and GPR37L1 baits were transformed with a number of PICK1 fish truncated mutants and tested for their ability ...
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New players in the sepsis protective activated protein C pathway
... in endothelial cells (2), Cao et ...sphingosine-1-phosphate receptor 1 mimicked the ability of aPC to reduce pro- duction of the inflammatory cytokine ...
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New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
... When imatinib, the first available signaling pathway in- hibitor, was introduced in CML, it was regarded as a highly BCR-ABL-specific drug. With both an increase in the number of treated patients and the development of ...
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Rare platelet G protein-coupled receptor variants : what can we learn?
... TP-α receptor agonists, showed apparently normal calcium mobilization, suggesting a possible additional pro-aggregatory effect of TP-α receptor activation that is independent of calcium ...(WT) ...
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The first open-reading frames of Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus and their contributions to the viral life-cycle
... classic KS and in iatrogenic and AIDS KS in the Middle East and Asia, whereas U.S. AIDS KS samples were primarily A1, A4, and C3 variants. More recent studies have further divided the virus into six subtypes: A, B, ...
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Human Trophoblast Progenitor Cells Express and Release Angiogenic Factors
... Human term placentas of normal pregnancies (range 38–42 weeks, n= 6) were obtained after spontaneous delivery or caesarean section with informed consent. Approval of the Ethic Committee of the Medical University of ...
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