Endothelin-1
The acute effect of high intensity aerobic training on ANP and Endothelin-1 in obese women
... The prevalence of overweight and obesity have increased dramatically worldwide and together they constitute a major risk factor for coronary heart disease. The aim of this study was to assess the effect of acute high ...
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Messenger RNA expression and synthesis of endothelin 1 along rat nephron segments
... The kidney both produces and responds to endothelin. We examined the production and the expression of mRNA of endothelin-1 (ET-1) in tubule suspensions and microdissected nephron segments. ...
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Endothelin 1/endothelin B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
... the endothelin-B (ET B ) receptor increases NHE3 ...M endothelin-1 (ET-1) increased NHE3 activity, but this treatment had no effect on tubules from Tg/Tg:ET B –/– ...
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Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents
... Background: Essential arterial hypertension (EAH) in adolescents represents a social burden. The endothelium is involved in the pathogenesis of EAH. Imbalance of key vasoactive factors – namely nitric oxide (NO) and ...
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Adrenomedullin and endothelin 1 are associated with myocardial injury and death in septic shock patients
... ET-1, endothelin-1; hsTNT, high-sensitivity troponin T; ICU, intensive care unit; LR-, negative likelihood ratio; LR+, positive likelihood ratio; LV, left ventricle; LVOT VTI, velocity time integral ...
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Role of Endothelin 1/Endothelin A receptor mediated signaling pathway in the aortic arch patterning in mice
... derivatives. Endothelin-1 (ET-1) is proteolytically generated from its inactive precursor by endothelin-converting enzyme-1 (ECE-1) and acts on the endothelin-A (ETA) ...
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Endothelin 1, superoxide and adeninediphosphate ribose cyclase in shark vascular smooth muscle
... substances or stretch of the vascular wall. Endothelin-1, which is produced by the vascular endothelium, acts locally to cause vasoconstriction. In all animals, the ability to regulate systemic blood flow ...
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Requirements for Endothelin type A receptors and Endothelin 1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
... for Endothelin 1 (Edn1) signaling in dorsoventral (DV) patterning of the pharyngeal skeleton (Clouthier et ...known Endothelin peptides, each synthesized as a larger pre- propeptide and subsequently ...
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Growth inhibitory properties of endothelin 1 in human hepatic myofibroblastic Ito cells An endothelin B receptor mediated pathway
... endothelin-1 (ET-1), we investigated its effects on the proliferation of human Ito cells in their myofibroblastic phenotype. Both ET receptor A (ETA: 20%) and ET receptor B (ETB: 80%) binding sites ...
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Endothelin 1 is an autocrine/paracrine growth factor for human cancer cell lines
... peptide, endothelin-1 (ET-1), is synthesized by and released from human carcinoma cell lines, and whether ET-1 stimulates proliferation of these tumor ...
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Osmolar regulation of endothelin 1 production by rat inner medullary collecting duct
... Recent evidence has implicated endothelin-1 (ET-1) as an autocrine inhibitor of inner medullary collecting duct (IMCD) sodium and water transport. The regulators of IMCD ET-1 production are, ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... Results: For the polymorphisms of Receptor A from Endothelin -1 studied the presence of cytosine homozygous genotype was less frequent in males (P = .02). For both genders, the same genotype was associated ...
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Direct and sympathetically mediated venoconstriction in essential hypertension Enhanced responses to endothelin 1
... of endothelin-1 and norepinephrine in 12 patients with essential hypertension who had never received treatment and in 12 age and sex matched normotensive control ...to endothelin-1 was ...
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Endothelin 1 mRNA is widely expressed in porcine and human tissues
... Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. We have previously demonstrated widespread binding sites for ET-1 in blood vessels, heart, ...
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Correlation between Endothelin-1 and oxidative stress in apparently healthy obese men
... obesity. Endothelin-1 is a useful marker of endothelial ...between Endothelin-1 and oxidative stress among apparently healthy obese ...
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Prevention of Inflammation-Associated Preterm Birth by Knockdown of the Endothelin-1-Matrix Metalloproteinase-1 Pathway
... of endothelin-1 (ET-1) ac- tion through the use of an endothelin-converting enzyme-1 (ECE-1) inhibitor, an established commercially available endothelin receptor ...
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Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin
... analyzed with a mixed linear model to assess the effect of leptin concentrations (from 0.001 to 100 nmol/L by step of 0.1 mol/L) or the effect of time of a leptin con- centration of 100 nmol/L (from 5 to 25 minutes by ...
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Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population.
... humans. Endothelin-1 (ET-1) expression has been linked to resistance artery remodeling, suggesting that it may increase the risk of hypertension development (Schiffrin, 2000; Delarue et ...
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Study of Association of 8002 G>A And 138 Del a Polymorphisms of Endothelin 1 (EDN 1) Gene with Essential Hypertension
... endothelium, Endothelin 1 (EDN-1) gene product is a strong vasoconstrictor resulting in vasoconstriction, there by playing an important role in blood pressure ...
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Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein–coupled receptor endothelin A receptor ...enzyme 1 ...
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