Endothelin-1 and -3
Endothelin 3 induces hypertrophy of cardiomyocytes by the endogenous endothelin 1 mediated mechanism
... that endothelin-1 (ET-1) mediates angiotensin II-induced hypertrophy of cardiomyocytes as an autocrine/paracrine ...whether endothelin-3 (ET-3) induces hypertrophy of cultured ...
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Effects of the 3 hydroxy 3 methylglutaryl CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin 1 and endothelial nitric oxide synthase in vascular endothelial cells
... of endothelin-1 (ET-1). The 3-hydroxy-3-methylglutaryl coenzyme A reductase in- hibitors (statins) have been shown to ameliorate endothelial ...• endothelin • nitric oxide • ...
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Role of Endothelin 1/Endothelin A receptor mediated signaling pathway in the aortic arch patterning in mice
... arteries 1 and 2 regress and become capillaries in branchial arches 1 and 2 by ...arteries 3 and 4 continue to ...arteries 3 remain to form bilateral common carotid arter- ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... Studies that have linked SNPs to functional pathological effects have not been repeated by other research groups. Similarly, the majority of studies that link polymorphisms to phenotypes and/or diseases are either ...
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Endothelin 1/endothelin B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
... with equal affinity, one would predict that the observed increase in ET-1 and decrease in ET-3 would cancel each other out. However, because the endothelins are autocrine/paracrine factors, this would ...
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Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population.
... exon 1 at position +138 (rs10478694), designated as 3A/3A (wild type/deletion), 3A/4A, 4A/4A (mutation/insertion); and b) a G/T transversion at position +5665 (rs5370) affecting the 61st nucleotide of exon 5, ...
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Expression and localization of endothelin 1 and endothelin receptors in human meningiomas Evidence for a role in tumoral growth
... hybridization and immunohistochemistry, whereas ET-Br mRNA was expressed at low level only in cells belonging to blood vessels. In addition, we found that ET-1 stimulated [3H] thymidine incorporation in primary ...
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Therapeutic Trial of an Endothelin Receptor Agonist for the Highly Pathogenic Avian Influenza A/H5N1 Virus Infection in Chicks
... The endothelin-1 (ET1) and endothelin receptor A (ETA) expression levels were quantified by real-time RT- PCR using a StepOne Real Time PCR System (Applied ...5’-GCTTCCCCGTCTCACTGAT- 3’) The ...
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
... Following the treatments, total RNA from cells was extracted using TRIzol® Reagent (Bio-Rad Laboratories Ltd., Mississauga, ON) according to the manufacturer’s instructions. Briefly, following 24 hours of treatment, ...
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Role of endothelin-1 in lung disease
... in 1 s (FEV 1 ) [29,50,51]. As in cultured epithelial cells, ET-1 and ET-3 are found in equal amounts in BAL fluid from asthmat- ics ...
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Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
... In terms of the relationship between plasma ET-1 levels and clinical factors in RP, mean plasma ET-1 levels of more deteriorated in visual acuity (Table 2), and visual field MD (Table 3) was lower ...
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β-arrestin1 at the cross-road of endothelin-1 signaling in cancer
... pathway of GPCR, like ET-1R, in cancer. This function is largely related to the ability of β-arr to act as multi- functional adaptor capable to finely modulate multiple signaling pathways involved in tumor growth and ...
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Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats
... higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/-51 ...B-type endothelin receptors had higher HCO3 secretion than baseline (NH4)2SO4 animals ...A-type ...
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Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... (Table 1). ETAR, ET-1, and ECE-1 colocalized with the peptidergic marker calcitonin gene–related peptide (CGRP) (ETAR, ...Table 1). Furthermore, 33% of ETAR- and ET-1–positive neurons ...
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Growth inhibitory properties of endothelin 1 in human hepatic myofibroblastic Ito cells An endothelin B receptor mediated pathway
... endothelin-1 (ET-1), we investigated its effects on the proliferation of human Ito cells in their myofibroblastic phenotype. Both ET receptor A (ETA: 20%) and ET receptor B (ETB: 80%) binding sites ...
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Endothelin 1 mRNA is widely expressed in porcine and human tissues
... Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. We have previously demonstrated widespread binding sites for ET-1 in blood vessels, heart, ...
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Molecular cloning and characterization of the endothelin 3 gene in black bone sheep
... From the database available online, we obtained 16 SNPs on chromosome 13, located close to EDN3 . We assumed that these have a correlation with the trait of our inter- est. Details of the SNPs are shown in Additional ...
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Requirements for Endothelin type A receptors and Endothelin 1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
... However, the weak rescue of cartilage that we observed in similar mosaics at 4 days post-fertilization (dpf) suggests that Edn1 from other tissues may act together with the ectodermally derived signal in later arch ...
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Statins: Newer Roles Including Lipid Lowering Therapy
... Statins are structurally similar to hydroxyl methyl glutaryl Coenzyme A (HMG-CoA), a precursor of cholesterol HMG-CoA reductase which regulates the rate-limiting step in the synthesis of cholesterol. They are most ...
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Molecular Characterization of a Dual Endothelin-1/Angiotensin II Receptor
... cording to the molecular recognition theory, these antisense homology regions should iden- tify putative AngII and ET-I binding domains, respectively.. Hydropathy analysis using the Kyte[r] ...
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