Endothelin – 1 (E-1)
Pulmonary vasoreactivity in spontaneously hypertensive rats - Effects of endothelin-1 and leptin
... the endothelin system has been well established in pulmon- ary arterial hypertension with demonstrated beneficial effects of endothelin receptor antagonists in these pa- tients ...of endothelin ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... Results: For the polymorphisms of Receptor A from Endothelin -1 studied the presence of cytosine homozygous genotype was less frequent in males (P = .02). For both genders, the same genotype was associated ...
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Role of Endothelin 1/Endothelin A receptor mediated signaling pathway in the aortic arch patterning in mice
... derivatives. Endothelin-1 (ET-1) is proteolytically generated from its inactive precursor by endothelin-converting enzyme-1 (ECE-1) and acts on the endothelin-A (ETA) ...
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Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population.
... humans. Endothelin-1 (ET-1) expression has been linked to resistance artery remodeling, suggesting that it may increase the risk of hypertension development (Schiffrin, 2000; Delarue et ...
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Prevention of Inflammation-Associated Preterm Birth by Knockdown of the Endothelin-1-Matrix Metalloproteinase-1 Pathway
... of endothelin-1 (ET-1) ac- tion through the use of an endothelin-converting enzyme-1 (ECE-1) inhibitor, an established commercially available endothelin receptor ...
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Endothelin 3 induces hypertrophy of cardiomyocytes by the endogenous endothelin 1 mediated mechanism
... that endothelin-1 (ET-1) mediates angiotensin II-induced hypertrophy of cardiomyocytes as an autocrine/paracrine ...whether endothelin-3 (ET-3) induces hypertrophy of cultured neonatal rat ...
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Neural peptidase endothelin converting enzyme 1 regulates endothelin 1–induced pruritus
... diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein–coupled receptor endothelin A receptor ...enzyme 1 ...
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Endothelin 1 mRNA is widely expressed in porcine and human tissues
... Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. We have previously demonstrated widespread binding sites for ET-1 in blood vessels, heart, ...
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Endothelin 1/endothelin B receptor–mediated increases in NHE3 activity in chronic metabolic acidosis
... the endothelin-B (ET B ) receptor increases NHE3 ...M endothelin-1 (ET-1) increased NHE3 activity, but this treatment had no effect on tubules from Tg/Tg:ET B –/– ...
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Growth inhibitory properties of endothelin 1 in human hepatic myofibroblastic Ito cells An endothelin B receptor mediated pathway
... endothelin-1 (ET-1), we investigated its effects on the proliferation of human Ito cells in their myofibroblastic phenotype. Both ET receptor A (ETA: 20%) and ET receptor B (ETB: 80%) binding sites ...
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Expression and localization of endothelin 1 and endothelin receptors in human meningiomas Evidence for a role in tumoral growth
... antagonist of ET-Br, did not block the proliferative effect of ET-1. In conclusion, our data provide evidence that ET-1 constitutes an important growth factor for meningiomas acting via ET-Ar. We can ...
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The role of endothelin-1 in hyperoxia-induced lung injury in mice
... It has been now established that, besides its vasoconstric- tive potential, ET-1 compromises the lung mechanics [7,11,14,18] and it may therefore play a role in the regu- lation of the airway tone. Separate ...
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Low levels of plasma endothelin-1 in patients with retinitis pigmentosa
... In terms of the relationship between plasma ET-1 levels and clinical factors in RP, mean plasma ET-1 levels of more deteriorated in visual acuity (Table 2), and visual field MD (Table 3) was lower than ...
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Molecular Characterization of a Dual Endothelin-1/Angiotensin II Receptor
... cording to the molecular recognition theory, these antisense homology regions should iden- tify putative AngII and ET-I binding domains, respectively.. Hydropathy analysis using the Kyte[r] ...
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β-arrestin1 at the cross-road of endothelin-1 signaling in cancer
... the E-selectin promoter as well as E-selectin expression, thus facilitating adhesion of monocytes to EC and endothelial damage, revealing a novel role for nuclear β-arr1 in the growth and metastasis of ...
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
... It has been two decades since studies linked cardiac hypertrophy and heart failure. Cardiac hypertrophy is an independent risk factor for myocardial infarction, angina pectoris, arrhythmia and cardiac sudden death (Levy ...
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Role of endothelin-1 in lung disease
... Activation of the receptors for ET-1 in the pulmonary vas- culature leads to both vasodilation and vasoconstriction, and depends on both cell type and receptor. In the whole lung, ETA receptors are the most ...
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UV induction of keratinocyte endothelin 1 downregulates E cadherin in melanocytes and melanoma cells
... for E-cadherin downregulation to ...of E-cadherin by ET-1 was observed in eight other primary melanocyte cultures and three addition- al melanoma cell lines (M20, WM123, and WM-266-4; Table ...cells, ...
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Elevated level of plasma endothelin-1 in patients with atrial septal defect
... Results: ET-1 levels at peripheral artery and vein in ASD patients were significantly higher than in the volunteers (p < 0.0001). The ASD subjects with highest ET-1 level presented the larger area of ...
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Therapeutic Trial of an Endothelin Receptor Agonist for the Highly Pathogenic Avian Influenza A/H5N1 Virus Infection in Chicks
... proteins; endothelin-1, endothelin-2 and endothelin-3 [16] ...[17]. Endothelin-1, a 23-residue peptide, is the most common endothelin produced by endothelial ...of ...
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