Endothelin receptor type A
Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL 8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients
... II receptor type 1 (AT1R) and the endothelin receptor type A (ETAR) were recently identified in the sera of SSc patients and are con- sidered to contribute to the pathogenesis of the ...
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The effects of behavioral stress and endothelin receptor antagonists on cancer
... Endothelin receptor antagonists inhibit the progression of many cancers, but research into their influence on glioma has been ...two endothelin receptor type B (ETRB)-specific ...
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Knockout of endothelin type B receptor signaling attenuates bleomycin induced skin sclerosis in mice
... (reverse); endothelin receptor type A (EDNRA), 5’-CCTTAT CTSCGTGGTCATTG-3’ (forward) and 5’-ACTGAGAG CACAGAGGTTC-3’ (reverse); endothelin receptor type B (EDNRB), ...
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Selective endothelin A-receptor blockade attenuates coronary microvascular dysfunction after coronary stenting in patients with type 2 diabetes
... All patients underwent one vessel PCI with coronary stenting with either drug-eluting stents or bare metal stents via 6-French guiding catheters. All patients received the low- molecular-weight heparin enoxaparin (0.5 mg ...
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Therapeutic Trial of an Endothelin Receptor Agonist for the Highly Pathogenic Avian Influenza A/H5N1 Virus Infection in Chicks
... proteins; endothelin-1, endothelin-2 and endothelin-3 [16] ...[17]. Endothelin-1, a 23-residue peptide, is the most common endothelin produced by endothelial ...of endothelin-1 ...
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Smoking particles enhance endothelin A and endothelin B receptor-mediated contractions by enhancing translation in rat bronchi
... Endothelin-1(ET-1) is the most potent vasoactive peptide described to date [5] and appears to have an important role in the regulation of pulmonary functions. It is synthe- sized, stored, released and metabolized ...
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Role of Endothelin 1/Endothelin A receptor mediated signaling pathway in the aortic arch patterning in mice
... 10), type B interrup- tion of the aortic arch (11), PTA (12), and double outlet right ventricle (DORV) (13), strongly resemble defects seen in neu- ral crest–ablated chick ...
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Focus on the target: the tumor microenvironment, Society for Immunotherapy of Cancer Annual Meeting Workshop, October 24th-25th 2012
... Dr. George Coukos presented an elegant characterization of the immunobiology of ovarian cancers. Almost 50% of ovarian cancer patients lack CD3 + TILs within nests of tumor epithelial cells, despite the presence of CD3 + ...
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Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats
... The present studies show that dietary acid increases ET-1 addition to RIF, a fluid compartment in direct communication with basolateral surfaces of cortical renal epithelium. This ana- tomical arrangement would permit ...
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Recombinase mediated cassette exchange reveals the selective use of Gq/G11 dependent and independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development
... jaw (arrow in B), in contrast to the normal one (A), appears a mirror image of the upper jaw with duplicated arrays of vibrissae. (C,D) Lateral and caudal views demonstrate defected and transformed mandibular (ventral) ...
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Salt sensitive hypertension in endothelin B receptor–deficient rats
... Dietary treatments. Rats were fed either a normal rodent diet (0.8% NaCl), a sodium-deficient diet (0.008% NaCl), or a high-sodium diet (8% NaCl). All diets were pur- chased from Harlan Teklad Laboratory (Winfield, Iowa, ...
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New horizons in pulmonary arterial hypertension therapies
... ABSTRACT Pulmonary arterial hypertension (PAH) is a fatal disease associated with vasoconstriction and vascular remodelling. There are three well-known pathways that contribute to the pathogenesis of PAH: ...
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Plasmatic Biochemical Variables Associated with Polymorphisms in the Endothelin-1 and Endothelin-1 Receptor a Genes in Hypertensive Patients: Pilot Study
... gene in male subjects (P=.02). Furthermore, the CC genotype is associated with normal plasma AP activity and cholesterol levels in carriers who are clinically characterized at recruitment without injury in organ target. ...
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<p>Management of digital ulcers in systemic sclerosis</p>
... Effect of the endothelin type A-selective endothelin receptor antagonist ambrisentan on digital ulcers in patients with systemic sclerosis: results of a prospective pilot study. Rademake[r] ...
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A novel PAX3 mutation in a Korean patient with Waardenburg syndrome type 1 and unilateral branch retinal vein and artery occlusion: a case report
... classification, type 1 (OMIM #193500) and type 2 (OMIM #193510) have similar features, but are distin- guished by telecanthus, which is present only in type ...in type 3 (OMIM# 148820), while ...
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Endothelins and Sarafotoxins: Peptides of Similar Structure and Different Function
... The endothelin family of peptides are very potent endo- genous vasoconstrictor and pressor agents, secreted by va- rious cells and tissues in the human ...with endothelin receptor antagonists have ...
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The effect of Bosentan on healing of colonic anastomosis
... an endothelin- receptor antagonist, can eliminate vasoconstruction, increase blood flow in the splanchnic area and anastomotic region and therefore possibly facilitate wound healing and prevent ...
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Potent anti inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice
... AIA in mice. Mice received daily oral administrations for 21 days beginning 2 hours before induction of AIA. Knee joint swelling and pain-related behavior were assessed repeatedly during the course of AIA (Figure 1a). On ...
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The role of combination therapy in managing pulmonary arterial hypertension
... duration) did not show a beneficial effect of sequential combination therapy on either a combined clinical worsening or survival end-point, although a modest improvement in exercise capacity was observed [15]. This ...
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Safety, efficacy, and clinical utility of macitentan in the treatment of pulmonary arterial hypertension
... Macitentan is a second-generation potent dual ERA with tissue targeting properties, its chemical name is N-5-(4- bromophenyl)-6-(2-[5-bromopyrimidin-2-yl]oxyethoxy)-N- ...
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