Endotoxin tolerance
The development of endotoxin tolerance, and the role of hypothalamo pituitary adrenal function and glucocorticoids in Pekin ducks
... GCs are known to contribute to a state of endotoxin tolerance in mammals (Beishuizen and Thijs, 2003). As yet, the role of GCs in the development and maintenance of endotoxin tolerance in ...
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The anti-idiotypic antibody 1F7 stimulates monocyte interleukin-10 production and induces endotoxin tolerance
... Convergent selection of anti-HCV antibodies bearing the 1F7 idiotype occurs during HCV infection and in- volves activation of B1 B cells [9]. Due to the high de- gree of V region connectivity between B1 B cells, they may ...
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mRNA based approach to monitor recombinant gamma interferon restoration of LPS induced endotoxin tolerance
... criterion for patients’ inclusion. Nevertheless, at the time of sampling, mHLA-DR expression in patients was decreased in comparison with normal values (Table 2). In further studies investigating this aspect, ...
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Endotoxin tolerance and cross tolerance in mast cells involves TLR4, TLR2 and FcεR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases
... Results: We found that production of TNFa and IL-6 in murine mast cells that have been pretreated with LPS and challenged with TLR4 (LPS) or -2 (P3C) agonists was reduced, phenomena described as endotoxin ...
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Inhibiting TNF-α signaling does not attenuate induction of endotoxin tolerance
... in endotoxin tolerance, we treated THP-1 cells with antibodies that neutralized the soluble TNF- α cytokine and/or antagonize TNF- α receptors at the time when they were stimulated with 100 ng/mL LPS for 2 ...
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The role of endotoxin during typhoid fever and tularemia in man: IV The integrity of the endotoxin tolerance mechanisms during infection
... typhosa endotoxin during illness rapidly induced a pyrogenic refractory ...the endotoxin tolerance mechanisms by any of the above methods, the febrile and toxic course of typhoid fever proceeded ...
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A Toll Like Receptor Responsive Kinase, Protein Kinase R, Is Inactivated in Endotoxin Tolerance through Differential K63/K48 Ubiquitination
... Since a role for differential Ub in endotoxin tolerance had not been described previously, we further explored this possibility. PKR activity has not heretofore been shown to be regulated by Ub. Therefore, ...
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Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance
... Accumulating evidence indicates that the subfornical organ (SFO) is a brain area that directly senses circulating LPS to produce proinflammatory cytokines. A sublethal dose of LPS causes a rapid production of ...
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Fractal-like kinetics of intracellular enzymatic reactions: a chemical framework of endotoxin tolerance and a possible non-specific contribution of macromolecular crowding to cross-tolerance
... to endotoxin (LPS), and subsequent signal transduction lead to the production of cytokines such as tumor necrosis factor- α (TNF- α ) by innate immune ...with endotoxin enter into a transient state of ...
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Original Article Endotoxin tolerance alleviates experimental acute liver failure via inhibition of high mobility group box 1
... of endotoxin cause them to become refractory to subsequent endotoxin challenge, a phenomenon called “endotoxin tolerance” ...toxin tolerance (ET) induced by low-dose LPS pretreatment ...
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Pathophysiology of endotoxin tolerance: mechanisms and clinical consequences
... is endotoxin tolerance ...to endotoxin challenges ...of tolerance in which ex- posure to low concentrations of endotoxins reprograms IIS ...further endotoxin challenges is ...
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Tyrosine phosphorylation of MyD88 adapter like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
... in endotoxin tolerance, including disrupted recruitment of MyD88 to TLR4 and altered IRAK-1-MyD88 association ...in endotoxin- tolerant 293/TLR4/MD-2 cells and human monocytes ...for endotoxin ...
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RelB Sustains IκBα Expression during Endotoxin Tolerance
... generating tolerance to interleukin-1  (IL-1  ) and tumor necrosis factor alpha (TNF- ␣ ) ...LPS tolerance and human SSI by activating and repressing innate immunity ...
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MicroRNA-181b regulates endotoxin tolerance by targeting IL-6 in macrophage RAW264.7 cells
... The expression of several miRNAs such as miR-155 and miR-146 has been demonstrated to increased after LPS treatment in previous studies, which have been a clue in LPS response and tolerance models [14]. To ...
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Mechanisms of endotoxin tolerance The role of the spleen
... pyrogenic tolerance to endotoxin is independent of anti-endotoxin antibody but that such antibody contributes significantly to the later phase (less than or equal to 72 h) of ...
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Interleukin 10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
... Thus, the lethal threshold dose of LPS for ILlOT mice may be extremely low as compared to that for wt mice because ILIOT mice are incapable of regulating not only TNFa production but als[r] ...
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ENDOTOXIN TOLERANCE I ITS INDUCTION BY EXPERIMENTAL PYELONEPHRITIS
... No differences were apparent between the febrile responses of nonoperated controls and sham-operated controls injected with an initial endotoxin challenge of formalin-killed bacteria equ[r] ...
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ENDOTOXIN TOLERANCE II ITS OCCURRENCE IN PATIENTS WITH PYELONEPHRITIS
... An earlier study demonstrated quite conclusively that the induction of pyelonephritis with gram-negative bacteria produced tolerance in rabbits known to respond normally to endotoxin and[r] ...
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Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance
... LPS tolerance, the groups that received the low (tolerizing) exposure to LPS (Groups “T” and “TD”) received 30 min of treatment with either NaHS or AOAA before the low concentration of ...
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Effect of 6 Mercaptopurine on Endotoxin Tolerance
... When the effluents from the first fractions were subjected to immunoelectrophoresis, the macroglobulin precipitin line was obvious only in the first fraction from the control animals but[r] ...
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