Enoyl-ACP reductase
STUDY OF STRUCTURE BASED DESIGN FOR SULFONES AS ENOYL ACP REDUCTASE INHIBITORS
... Preparation of Ligands: Structure of the Enoyl- ACP reductase inhibitors was sketched using a built panel of Maestro and taken in.mae format. Ligand Preparation is a utility of Schrodinger software ...
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“Structure-Based Design of Benzophenone Inhibitors Targeting ENOYL-ACP Reductase Enzyme” by M. M. V. Ramana, R. S. Lokhande, Urmila. J. Joshi, Gayatri. V. Gadre, Akshada. J. Joshi, India.
... protein reductase enzyme The enzymes of the fatty acid biosynthesis pathway (FAS II) in bacteria, represent interesting targets for antimicrobial drug design because their mammalian counterpart FAS I uses a ...
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Identification of a New Potential Reductase Inhibitor as an Anti-Tubercular Agent for Enoyl-Acp Reductase Inha Gene of Mycobacterium tuberculosis in Comparison with PT70 (5-Hexyl-2-(2-Methylphenoxy) Phenol)
... 12. APan P, J Tonge P. Targeting InhA, the FASII enoyl-ACP reductase: SAR studies on novel inhibitor scaffolds. Current topics in medicinal chemistry. 2012;12(7):672-93; BEncinas L, O’Keefe H, Neu M, ...
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Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by a Thermal Shift Assay
... enzyme Enoyl-ACP Reductase (ENR) is responsible for the final reductive step in each round of fatty acid chain elongation, the NADH-dependent reduction of trans-2-enoyl-ACP to acyl- ...
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DESIGN, SYNTHESIS, AND DOCKING OF SULFADIAZINE SCHIFF BASE SCAFFOLD FOR THEIR POTENTIAL CLAIM AS INHA ENOYL (ACYL CARRIER PROTEIN) REDUCTASE INHIBITORS
... the enoyl-ACP reductase (InhA) of MTB were carried out to determine the best ...conformation. Enoyl-ACP reductase (ENR) is a key enzyme of the type II fatty acid synthesis system ...
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Screening of Annona muricata for E coli enoyl acyl carrier protein reductase inhibitors by molecular docking
... Chemical compounds isolated from plant sources are most common natural products that exhibit a broad spectrum of antibacterial activity. In order to decipher antibacterial activity of A.nuricata compounds and growth ...
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IDENTIFICATION OF NEW COMPOUNDS AGAINST ISONIAZID TARGET OF MYCOBACTERIUM TUBERCULOSIS
... INH and ETH are both prodrugs that are activated by the catalase-peroxidase KatG or the monooxygenase EthA, respectively. The activated forms react with NAD_ to form an INH- NAD or ETH-NAD adduct. These adducts inhibit ...
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3-D QSAR CoMFA Models of Pyrrolidine carboxamides for Prediction of Enoyl acyl carrier protein reductase Inhibitory Activity
... NADH-dependent enoyl-ACP reductase of the fatty acid synthase type II system are inhibited by these two adducts which leads to the inhibition of mycolic acid biosynthesis and cell ...
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Early detection of multidrug and pre extensively drug resistant tuberculosis from smear positive sputum by direct sequencing
... Abbreviations ahpC: Alkyl hydroperoxide reductase gene; FQ: Fluoroquinolone; gyrA: Gyrase A subunit gene; INH: Isoniazid; inhA: NADH-dependent enoyl-ACP reductase gene; katG: Mycobacteri[r] ...
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Retusenol Potentially Inhibits Putative Drug Targets for Tuberculosis, Cardiovascular Diseases, Cancer and HIV: A Reverse Docking Study
... following: Enoyl-acp reductase, Lanosterol synthase, Polo-like kinase 1, and ...Integrase. Enoyl-acp reductase, Lanosterol Table 1: Calculated Binding Energies of Retusenol and ...
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Proteomic profiling of fatty acid biosynthetic enzymes from oil palm chromoplast
... β-ketoacyl- ACP synthase), were found to have more detected peptides in both varieties compared to acetyl-CoA carboxylase, β-ketoacyl-ACP synthase and stearoyl-ACP ...3-enoyl-ACP ...
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Design, synthesis, toxicity estimation and molecular docking studies of N-(Furan-2-yl)-1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimine as antitubercular agents
... The design of newly synthesized N-(furan-2-yl) -1-(5-substituted) phenyl-1,3,4-oxadiazol-2-yl) methanimines as enoyl ACP-reductase inhibitor was based up on the similarity based structural features ...
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Molecular docking studies on InhA, MabA and PanK enzymes from Mycobacterium tuberculosis of ellagic acid derivatives from Ludwigia adscendens and Trewia nudiflora
... Several key enzymes involved in M. tuberculosis cell wall biogenesis and physiological functions have become attractive targets for the design of novel anti-TB agents (Jackson et al. 2013). Two of the target proteins of ...
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Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on Physiochemical Interactions with Isoniazid: Molecular Dynamics Simulation
... The resistance strains of Mycobacterium tuberculosis have complicated the tuberculosis management and therapy. Prior to the discovery of a more effective therapy, it is crucial to understand the molecular basis and ...
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Antigua & Barbuda joint annual report 2006
... within ACP trade ministries to assist with data collection, trade policy formulation and consultations with non-State actors, with a view to improving the countries’ trade capacities and trade ...English-speaking ...
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Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents
... 2003). Enoyl acyl carrier protein reductase (ENR) carries out one of two reductive steps in the type II FAS pathway and has been shown to be the target of several families of antimicrobial compounds, ...
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QSAR and Molecular docking Studies of oxadiazole ligated Pyrrole derivatives as Enol ACP co Reductase Inhibitors
... prediction of activity using MLR equation acts filter or screen for large library of designed compounds for selecting the best compound having better and predicted activity.All designed compounds shown good binding ...
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Role of Serine140 in the mode of action of Mycobacterium tuberculosis β ketoacyl ACP Reductase (MabA)
... β-ketoacyl-ACP Reductase (MabA) is a member of FAS-II system, which elongates acyl fatty acid precursors yielding the long carbon chain of the meromycolate branch of mycolic acids, the hallmark of ...
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Biosynthesis, regulation, and engineering of microbially produced branched biofuels
... fumarate reductase (encoded by frdAB), a regulator of fumarate and nitrate reduction (encoded by fnr), and a phosphate acetyltransferase (encoded by pta) that contributes to by-product ...
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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target
... 2 Enoyl acyl-carrier protein reductase (ENR), which carries out the final stage of FAS II synthesis, has been the main focus of drug development programs in this ...
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