Enterovirus A71
RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5′ Nontranslated Regions
... and enterovirus A71 (EV-A71) are closely related enteroviruses that cause the same hand, foot, and mouth disease (HFMD), but neurological complications occur only very rarely in CV-A16 compared to ...
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Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
... Human enterovirus A71 (EV-A71) is a neurotropic pathogen that can cause severe hand, foot, and mouth disease (HFMD) in children under 5 years ...(genus enterovirus, family picornaviridae, ...
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Squamous epitheliotropism of Enterovirus A71 in human epidermis and oral mucosa
... by Enterovirus A71 (Genus: Enterovirus, Family: ...of Enterovirus A71 in human skin and oral mucosa are ...In Enterovirus A71-infected human skin and oral mucosa ...
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Antivirals and vaccines for Enterovirus A71
... Enterovirus A71 (EV-A71), a positive-strand RNA virus of the family Picornaviridae, represents a persistent global health problem and has caused large outbreaks in the Asia-Pacific region in recent ...
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Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALM
... Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease (HFMD) that is associated with neurological complications. Researchers have shown that exosomes containing host cellular microRNA (miRNA) ...
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Validation and utilization of an internally controlled multiplex Real time RT PCR assay for simultaneous detection of enteroviruses and enterovirus A71 associated with hand foot and mouth disease
... with Enterovirus A of the family Picorna- viridae including coxsackievirus A6 (CV-A6), CV-A10, CV-A16, and enterovirus A71 (EV-A71) ...
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Interplays between Enterovirus A71 and the innate immune system
... Enterovirus A71 (EV-A71) is a growing threat to public health, particularly in the Asia-Pacific region. EV-A71 infection is most prevalent in infants and children and causes a wide spectrum of ...
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Molecular characterization of enterovirus A71 in children with acute flaccid paralysis in the Philippines
... Enterovirus-A71 (EV-A71) is an RNA virus belonging to the family Picornaviridae , genus Enterovirus , and species EV-A . Using the complete VP1 sequence for genetic classification, ...
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A novel role of ER stress signal transducer ATF6 in regulating enterovirus A71 viral protein stability
... possible cleavage pattern during viral infection, we trans- fected HA-ATF6(1-516aa)-FLAG into HEK293T cells to improve the efficiency of ATF6 expression. A multipli- city of infection (MOI) of 200 was used because ...
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A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans
... The proportion of VP1-31G correlated with disease severity in patients with EV-A71 infection. To determine whether evolutionary selection commonly acts on the mutant spectra of other EV-A71 strains while ...
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Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice
... The occurrence of brainstem encephalitis in EV-A71-infected patients was found to be associated with the local production of proinflammatory cytokines, and a number of clinical reports also suggested that an ...
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Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation
... infected cells were set as the control. 2-DE was performed as described in a paper recently published by the M.-L. He lab (38). Briefly, cells were washed with phosphate-buffered saline (PBS) and lysed in lysis buffer (8 ...
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Molecular Characterization of Human Enteroviruses in the Central African Republic: Uncovering Wide Diversity and Identification of a New Human Enterovirus A71 Genogroup
... In conclusion, this retrospective report highlights the consid- erable diversity of HEV species circulating in the CAR. That pop- ulation contains a number of lineages of viruses circulating world- wide but also several ...
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Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China
... In order to prevent serious neurological and cardiopul- monary complications (aseptic meningitis, encephalitis, encephalomyelitis, acute flaccid paralysis, or autonomic nervous system dysregulation, pulmonary edema, pul- ...
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Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam
... Currently, there is no specific antiviral treatment available for EV-A71. Phase III trials of three different inactivated EV-A71 vac- cines from China have recently been completed and have shown 95% ...
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Enterovirus A71 neurologic complications and long-term sequelae
... infected children, were asymptomatic, 73% had uncom- plicated illnesses of hand, foot and mouth disease, herpangina or nonspecific febrile illness and 21% suffered from complications of central nervous system involvement ...
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Suppression of interleukin-6 increases enterovirus A71 lethality in mice
... To investigate the role of endogenous IL-6 in EV-A71 infection, we infected and compared wild-type C57BL/ 6J mice and C57BL/6J–derived mice with a targeted disruption of the gene encoding IL-6. Both wild-type mice ...
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Enterovirus A71: virulence, antigenicity, and genetic evolution over the years
... region had been found to increase viral fitness (Fig. 1) [66]. The 3C region has been reported to be able to interfere with the host innate defense by selectively inhibiting the synthesis of type I interferon (IFN), and ...
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Mapping Enterovirus A71 Antigenic Determinants from Viral Evolution
... Although enteroviruses rarely display antigenic drift to escape vaccine-mediated immunity (28, 29), they are often observed to have evolving antigenic properties (30). As an example of the im- portance of mutations in ...
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The History of Enterovirus A71 Outbreaks and Molecular Epidemiology in the Asia-Pacific Region
... convincing evidence for the induction of cross- protection among the diversity of subgenogroups in cir- culation throughout the region and globally, including CV-A6 and CV-A16 associated with HFMD, remains to be ...
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