Envelope glycoprotein
Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain
... gp160 glycoprotein. This glycoprotein was expressed efficiently on the cell surface and was precipitated by antibodies that recognize conformation-depen- dent gp120 epitopes (29, ...the envelope ...
6
Crystal Structure of the West Nile Virus Envelope Glycoprotein
... The envelope glycoprotein (E) of West Nile virus (WNV) undergoes a conformational rearrangement triggered by low pH that results in a class II fusion event required for viral ...
8
Changes in the Extracellular Envelope Glycoprotein of Variants That Evolve during the Course of Simian Immunodeficiency Virus SIVMne Infection Affect Neutralizing Antibody Recognition, Syncytium Formation, and Macrophage Tropism but Not Replication, Cytopathicity, or CCR-5 Coreceptor Recognition
... variant envelope genes representative of proviruses throughout the course of infection and disease into the SIVMne parental clone (SIVMneCL8) that infected the ...the envelope glycoprotein (Env-SU) ...
9
Sorting of CD4 and the SIV envelope glycoprotein in the endocytic pathway
... I used the polymerase chain reaction (PGR) to amplify the cDNA corresponding to the cytoplasmic domain of SIV-TM [SIV-TM(cyt)] from the pSFVl-BK28 plasmid. The envelope glycoprotein from the BK28 virus has ...
226
A ligand-binding pocket in the dengue virus envelope glycoprotein
... Three structural proteins (‘‘C,’’ ‘‘M,’’ and ‘‘E’’) and a lipid bilayer package the positive-strand RNA genome of flaviviruses (3). The core nucleocapsid protein, C, assembles with RNA on the cytosolic face of the ...
7
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
... (HCV) envelope glycoprotein complex is composed of E1 and E2 ...this glycoprotein by mutating resi- dues within this 79-amino-acid region in the context of an infectious ...HCV glycoprotein E1 ...
19
Characterization of the Envelope Glycoprotein of a Novel Filovirus, Lloviu Virus
... Lloviu virus (LLOV), a novel filovirus detected in bats, is phylogenetically distinct from viruses in the genera Ebolavirus and Marburgvirus in the family Filoviridae. While filoviruses are known to cause severe ...
11
Human immunodeficiency virus type 1 envelope glycoprotein molecules containing membrane fusion-impairing mutations in the V3 region efficiently undergo soluble CD4-stimulated gp120 release.
... Plasmid pPE7H contains the HIV-1 envelope Human immunodeficiency virus type 1 HIV-1 infection is initiated by binding of the viral envelope glycoprotein to CD4 molecules on the surface o[r] ...
5
Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry
... F522Y/L523S envelope glyco- proteins, respectively (Fig. 1A). These envelope glycoprotein variants have alterations in the gp41 fusion peptide that, re- spectively, diminish or eliminate ...
7
Role of the Stable Signal Peptide of Junín Arenavirus Envelope Glycoprotein in pH-Dependent Membrane Fusion
... the envelope glycoprotein (GP-C) mediates entry of the virus into the host cell and is the primary target for virus-neutraliz- ing antibodies (24, 44), there have been extensive efforts to understand its ...
6
Assembly of Arenavirus Envelope Glycoprotein GPC in Detergent-Soluble Membrane Microdomains
... The family Arenaviridae includes a number of highly pathogenic viruses that are responsible for acute hemorrhagic fevers in humans. Genetic diversity among arenavirus species in their respective rodent hosts supports the ...
11
Feline Tetherin Is Characterized by a Short N-Terminal Region and Is Counteracted by the Feline Immunodeficiency Virus Envelope Glycoprotein
... the envelope-encoding sequence (FIV ...FIV envelope glycoprotein is the viral factor counteracting ...FIV envelope glycoprotein significantly rescues viral mutant budding in the ...
13
Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype
... In this study we examined whether human immunodeficiency virus type 1 (HIV-1) is equally susceptible to neutralization by a given antibody when the epitope of this antibody is introduced at different positions within the ...
11
An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes.
... It follows that if HIV-induced cytopathology involves permeabilization of cell membrane by its interaction with the carboxy terminus of the envelope glycoprotein, the numbers and the siz[r] ...
9
Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV 1) envelope glycoprotein
... Human immunodeficiency virus (HIV-1) entry into cells is mediated by the envelope glycoprotein (Env) spike on the viral membrane [1]. The trimeric Env complex is a Type 1 membrane protein composed of three ...
16
Stabilization of the Soluble, Cleaved, Trimeric Form of the Envelope Glycoprotein Complex of Human Immunodeficiency Virus Type 1
... The envelope glycoprotein (Env) complex of human immunodeficiency virus type 1 has evolved a structure that is minimally immunogenic while retaining its natural function of receptor-mediated virus-cell ...
15
Dynamic electrophoretic fingerprinting of the HIV 1 envelope glycoprotein
... gp120 glycoprotein and have shown poor induction of broadly neutralizing antibodies against clinically-relevant viral strains ...functional envelope- bound ...native envelope and the recombinant ...
22
Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.
... The presence of wild-type levels of gpl20 glycoprotein in the supernatants of COS-1 cells transfected with the plasmids expressing the mutant envelope glycoproteins suggested that these [r] ...
5
Role of reticuloendotheliosis virus envelope glycoprotein in superinfection interference.
... Interestingly, cells chronically infected with either SNV or REV-A two closely related REV species exhibited a higher level of resistance to infection than did either the cell clones exp[r] ...
8
Structure of the murine leukemia virus envelope glycoprotein precursor.
... DISCUSSION The data presented demonstrate that the Moloney MuLV glycoprotein precursor Pr8Oenv is a molecule with a apoprotein portion having a molecular weight of 60,000 and at least tw[r] ...
9