EP2 receptor
Cancer associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
... of EP2-null T cells, and, in fact, loss of the EP2 receptor decreased the ability of ovalbumin-specific T cells to respond to antigen (Figure ...the EP2 receptor does not appear to ...
10
Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells
... the EP2 receptor by inhibiting COX-2, JAK2, STAT3, and MAPKs in EMF-stimulated N9 ...that EP2 activation was blocked by celecoxib, AG490, S3I-201, SB203580, PD98059, and AH6809 in EMF-stimulated N9 ...
14
EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis
... EP2 receptor antagonism reduces peripheral and central hyperalgesia in a preclinical mouse model of endometriosis Erin Greaves1, Andrew W. Horne1, Helen Jerina2, Marta Mikolajczak2, Lisa[r] ...
10
Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients
... The EP2 receptor also contributes to spinal pain sensitization during inflammatory pain states [28, ...EP4 receptor subtype in rat sensory dorsal root ganglion (DRG) neurons ...and EP2 ...
7
Prostaglandin E2 receptor type 2 selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability
... EP receptor, EP1 to ...each receptor [18]. Using an EP2 selective agonist, we showed that EP2 receptor-mediated PGE2 signaling enhances the growth of chondrocytes [18,19] and pro- motes ...
13
Decreased RORC dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells
... prostaglandin receptor EP2 on Th17 cells; therefore, we examined the hypothesis that RORgt, which is highly expressed in Th17 cells, mediates EP2 ...encoding EP2 receptor) in Th17 cells ...
11
Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ – prostaglandin E2dependent proliferation of growth plate chondrocytes
... EP2 receptor was identified as the major PGE 2 receptor ...line, EP2 agonists evoked cAMP generation and promoted cell ...the EP2 recep- tor whereas in growth plate chondrocytes the EP1 ...
11
Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide
... Cells were lysed in radioimmunoprecipitation assay (RIPA) buffer containing protease inhibitors. Five micro- grams of protein were resolved by SDS-PAGE, and the proteins were transferred to polyvinylidene difluoride ...
13
EP2-PKA signaling is suppressed by triptolide in lipopolysaccharide-induced microglia activation
... Microglial EP2 is critical to the neurotoxicity caused by the activation of cerebral innate ...whether EP2 is involved in the anti-inflammatory effect of triptolide in LPS-stimulated microglia, we first ...
9
Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein
... ablating EP2 receptor? To this end, one of the potential fruitful areas in the further research could be cAMP- dependent signal transduction ...that EP2 regulates the intracellular levels of cAMP ...
10
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
... Disruption of the gene encoding the EP2 receptor. (a) Restriction maps of the targeting construct, endogenous locus, and targeted locus. The dark filled box represents exon sequences of the Ep2 gene. ...
8
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
... horn (Figures 4B and 5B, respectively). To verify the spinal origin of the delayed sensitization, we tested the effect of COX-2 inhibition in WT mice at different time points after zymosan A injection (Figure 5). ...
8
Index Catalog // Carolina Digital Repository
... EP1 receptor, EP2 receptor, EP3 receptor, thromboxane receptor, prostacyclin receptor, HPGD, Cox-1, and Cox-2 is described elsewhere [6, ...(EP1, EP2, EP3, prostacyclin ...
124
Expression profiles of genes involved in TLRs and NLRs signaling pathways of water buffaloes infected with Fasciola gigantica
... Toll-like receptor 1 TLR2 Toll-like receptor 2 TLR3 Toll-like receptor 3 TLR4 Toll-like receptor 4 TLR5 Toll-like receptor 5 TLR6 Toll-like receptor 6 TLR7 Toll-like ...
37
The structure and function of the CGRP receptor
... In RAMP1, mutations of Y66A, L69A and T73A in helix 2, P85A, N86A in the loop from helix 2 to helix 3, and H97A and F101A in helix 3 all impaired cAMP production (Figure 1.12). The crystal structure shows that RAMP1 Y66 ...
296
Differential trypanosome surface coat regulation by a CCCH protein that co-associates with procyclin mRNA cis-elements
... Immunoprecipitation using TbZFP3-specific antisera, RNA ex- traction and reverse transcription have been described previously [18]. Blocking peptides used were N-DSSQMQQVGHDVPPMA-C for TbZFP3 and N-EVHTNQDPLD-C for Ty1, ...
10
PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts
... DOC 325 kb Abbreviations ACPA: anticitrullinated peptide antibodies; AS: ankylosing spondylitis; CI: confidence interval; EAC: Leiden Early Arthritis Clinic cohort; EP2: prostaglandin E2[r] ...
11
Expression and localization of prostaglandin receptors and stromal factors in human cervix—Variations in pregnant and non pregnant states
... The low mRNA levels of EP2 and EP4 in smooth muscles of the TP group, along with the changes in the relative protein levels of tissue remodeling stromal factors like CTGF, calgranulin B,[r] ...
11
Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma
... 2/neu receptor studies are known to be prognostic and predictive biomarkers of breast ...the receptor status is to decide on the best treatment regime for breast cancer ...HER2/neu receptor status ...
6
Immunological and virological investigations into sporadic ovine lymphoma : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy at Massey University
... surface membrane immunoglobulin receptor for aggregated IgG receptor for antibody- coated bovine erythrocytes receptor for antibody-coated human erythrocytes receptor for erythrocyte - a[r] ...
222