Ephrin-B2
Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis
... of ephrin B2 or its receptor EphB4 also leads to enlarged aortae and underdeveloped cardinal veins; however, endothelial cells with venous identity are mislocalized in the aorta, suggesting that ...
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Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes
... of ephrin B2 on OA chondrocytes was assessed by incubating the cells with either 50 or 100 ng/ml of human recombinant ephrin B2 (Abnova, Taipei, Taiwan) in the absence (gene expression) or ...
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Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
... the ephrin B2- EPHB4 interaction with the TNYL-RAW peptide inhibited osteoclast formation supported by the ATDC5 chondrocyte cell line (Wang et ...the ephrin B2/EPHB4 role in chondrocytic ...
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Exploring the Horizons of Ephrin B2 Receptor for Combating Paramoxyviridae Infection
... The Hendra and Nipah viruses (HeV and NiV) are prominant members of the Paramyxoviridae family [1]. The initial cases were detected in Australia in 1994-95 and Malaysia in 1998-99. Henipa viruses have been transmitted to ...
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Ephrin B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail
... [15,17-19]. Ephrin-B2 (EB2) is known to act as main entry receptor for NiV [20,21], and its expression on endothelial cells, smooth muscle cells and neurons [22-26] is highly con- sistent with the known ...
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Cartilage specific deletion of ephrin B2 in mice results in early developmental defects and an osteoarthritis like phenotype during aging in vivo
... Our findings from imaging and bone densitometry showed that EFNB2Col2KO mice at P21 and 8 weeks of age displayed reduced bone mass with lower mineral content and trabeculae formation, re[r] ...
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Isolation and functional analysis of Xenopus ephrin-A3
... of ephrin-B 1, ephrin-B2 and ephrin-B3, the three members of the ephrin-B class, where found to have strong sequence conservation of the 33 amino acids at the C-terminal ...the ...
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Eph/ephrin signalling during development
... about ephrin reverse signalling. Ephrin B reverse signalling typically involves tyrosine phosphorylation of its intracellular domain and recruitment of PDZ domain-containing proteins (Xu and Henkemeyer, ...
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Presenilin-dependent intramembrane cleavage of ephrin-B1
... of ephrin-B ligands, that contains conserved tyrosine resi- dues, mediates the phosphorylation-dependent and - independent reverse signaling, in cooperation with its binding proteins in FL ...that ephrin-B ...
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Paradoxes of the EphB1 receptor in malignant brain tumors
... that ephrin-B2 con- trols cell motility and adhesion during blood vessel wall assembly by EphB4-ephrin-B2 interactions that recruit the adaptor molecule Crk and p130 (Cas) signaling com- plex ...
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Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons
... in ephrin-B2 lacZ/+ and EphB2 −/− ;EphB3 −/− mice, which have diminished EphB signaling, a significant number of ipsilateral calyceal projections to MNTB were found [8, ...that ephrin-B2 is ...
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<p>In vivo Screening of Natural Products Against Angiogenesis and Mechanisms of Anti-Angiogenic Activity of Deoxysappanone B 7,4ʹ-Dimethyl Ether</p>
... 2, ephrin B2, fi broblast growth factor receptor (fgfr) 3, cycloox- ygenase-2, protein tyrosine phosphatase, receptor type B (ptp-rb), phosphoinositide-3-kinase regulatory subunit 2, slit guidance ligand ...
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Antibodies to Henipavirus or Henipa Like Viruses in Domestic Pigs in Ghana, West Africa
... Luminex ephrin-B2 receptor blocking (inhibition) assay and by virus neutralization tests (VNTs) ...block ephrin-B2-G glycoprotein interactions in a dose dependent fashion ...
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Investigation of ephrin regulation during hindbrain segmentation
... the ephrin-B2 locus has been isolated in two PAC clones - 383-111 and 548-N22 (section ...the ephrin-B2 start codon by the ET-cloning m ethod of homologous recombination in bacteria and the ...
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Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina
... for ephrin-B2 in the dorsal retina. The fact that EphB-ephrin B signaling specifies retinotopic mapping along the DV axis has been demonstrated by several ...EphB- ephrin B interactions are ...
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Identification and characterization of endothelial specific genes
... angiogenesis defects in the conditional mutants are similar to those in ephrin-B2 conventional mutants. However, endocardial cells in the conditional mutants display normal trabeculation in the right ...
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PSGL 1–mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells
... their ephrin ligands are key regulators of vascular ...an ephrin-B2–Fc chimeric protein increases the angiogenic potential of human ...blocked ephrin-B2–Fc–stimulated EPC adhesion ...
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EPHB4 kinase–inactivating mutations cause autosomal dominant lymphatic related hydrops fetalis
... here that kinase-inactivating mutations in EPHB4 can produce a lymphatic phenotype in humans that can be classified as LRHF/ GLD. However, this phenotype shows highly variable expression. Some individuals present with ...
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Eph and NMDA receptors control Ca2+/calmodulin dependent protein kinase II activation during C elegans oocyte meiotic maturation
... antagonizes ephrin/VAB-1 and CEH-18-dependent inhibition ...block ephrin/VAB- 1 signaling at the receptor level or it could trigger a switch from negative to positive regulation ...
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Alternatives for the substitution of synthetic vitamin B2 or vitamin B2 produced from GMOs
... vitamin B2 is produced almost exclusively from a GMO,1 namely the genetically modified Bacillus ...Vitamin B2 applied in certified organic food and feed productions is an exception, as it is still syn- ...
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