Epigenetic mechanism
Defining the Epigenetic Mechanism of Asymmetric Cell Division of Schizosaccharomyces japonicus Yeast
... the epigenetic mechanism of asymmetric cell division of this organism and compare it to that of the well-studied ...of epigenetic mecha- nisms underlying asymmetric cell ...
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
... The impact of apabetalone on RelA/p65 translocation and BRD4 chromatin occupancy was assessed to deter- mine if the BD2-specific apabetalone suppresses VI tran- scription through the same mechanism as the pan-BETi ...
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<p>Epigenetic mechanism controls <em>PDK4</em> gene activation before and after exercise therapy following artificial knee arthroplasty</p>
... In this study, we veri fi ed that the actual skeletal muscle of elderly patients underwent DNA methylation. We measured the methylation rate of PDK4 gene comprehensively on the CpG island using the NGS. To the best of our ...
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Epigenetic mechanism of FMR1 inactivation in Fragile X syndrome
... ABSTRACT Fragile X syndrome is the most frequent cause of inherited intellectual disability. The primary molecular defect in this disease is the expansion of a CGG repeat in the 5’ region of the fragile X mental ...
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Epigenetic mechanism and target therapy of UHRF1 protein complex in malignancies
... an epigenetic regulator recruiting PCNA, DNMT1, histone deacetylase 1, G9a, SuV39H, herpes virus-associated ubiquitin-specific protease, and Tat- interactive protein by multiple corresponding domains of DNA and H3 ...
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Original Article ART1 induces aberrant methylation
... Abstract: Colorectal carcinoma remains one of the most prevalent cancers with high morbidity and mortality. Arginine ADP-ribosyltransferase 1 (ART1) is one of the major mono-ADP-ribose transferases and has been shown to ...
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Global and gene-specific DNA methylation in adult type 2 diabetic individuals: a protocol for a systematic review
... an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus ...Furthermore, epigenetic therapy has been suggested as a future possibility for T2DM ...treatment. ...
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Epigenetics and Systems Physiology of Nutrition: An Overview
... DNA methylation and histone modification have joint role in regulation of transcription. Simultaneous evaluation of any dietary/nutrient influences on both the processes is thus necessary. Need for significant cell ...
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Clinicopathological significance and potential drug targeting of CDH1 in lung cancer: a meta-analysis and literature review
... important epigenetic mechanism for regulation of gene ...molecular mechanism involved in the epigenomic regulation of initiation and progression of ...
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Tracing anti-cancer and cancer-promoting actions of all- trans retinoic acid in breast cancer to a RAR aepigenetic mechanism of mammary epithelial cell fate
... epigenetic mechanism of normal mammary epithelial cell ...two-module mechanism inferred from evolutionary studies [16], the mechanism that we show here encompasses a ‘RA metabolic module’ ...
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Cross talk between Epigenetics and Human Disease-A multifaceted review
... Though DNA methylation and histone modification are known to interact, drugs that combines to inhibit DNMTs as well as HDACs may results in synergistic effects. In the cultured carcinoma cells, it was shown that four ...
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Changing Pattern of Histone H3 Methylation following treatment of erythroid progenitors derived from cord blood CD133+ cells with sodium butyrate and thalidomide
... the epigenetic mechanism of the effect of HbF inducing drugs in increased expression of γ-globin gene, H3K27 methylation pattern changes were assessed following treatment of erythtroid precursors with ...
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Genetic Determinants of Epigenetic Patterns: Providing Insight into Disease
... The simplest example of a genetic mu- tation driving an epigenetic change and contributing to disease is when the change occurs in a gene encoding an epi- genetic modifying enzyme. Some of the more recently ...
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Epigenetics and transgenerational inheritance in domesticated farm animals
... term epigenetic changes in pigs based on maternal ...an epigenetic effect on embryonic tissue development. Epigenetic programming in the porcine germline has also been reported ...
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PubMedCentral-PMC5361673.pdf
... and epigenetic aging rates probably reflect that a relatively large proportion of the variance in aging rates (around 40 percent) is explained by genetic factors [38, 59, ...with epigenetic age acceleration ...
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Diseases of the oral cavity in light of the newest epigenetic research: Possible implications for stomatology
... Hypodontia is caused by complex interrelations between genetic, epigenetic and environmental factors during den- tal development. In a pilot study that examined 6,636 hu- man genes, conducted by Wang et al., it ...
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Epigenetic inheritance and the missing heritability
... established. Epigenetic programs may account for a significant fraction of the “ missing ...” Epigenetic modifications, such as DNA methylation and chromatin assembly states, reflect the high plasticity of ...
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Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects
... the epigenetic changes arising as a consequence of alcohol exposure are heavily dependent on the gene under investigation, the dose of alcohol encountered, and that the signatures arising acutely differ ...
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Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro
... through epigenetic modifications, cells were incubated in the presence of 5-aza-2=-deoxycytidine (5azadC), a deoxynucleoside analogue that strongly inhibits DNA methyltransferase (DNMT) ...
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Identification of miR 379/miR 656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas
... Since an orchestrated expression pattern for majority of miRNAs from C14MC throughout the samples was observed in ODGs, therefore, this further suggests either the existence of a polycystronic primary miRNA transcript or ...
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