Epigenetic mechanisms
Epigenetic mechanisms in Alzheimer's disease
... logical studies indicate the importance of lifestyle factors in the prevention/delay of disease onset. Preclinical studies indicate that many lifestyle factors impact relevant genetic expression via epigenetic ...
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Genetic and epigenetic mechanisms in the development of arteriovenous malformations in the brain
... pathogenic mechanisms of AVMs are ...trigger epigenetic factors of the endothelial ...Aberrant epigenetic modifications in the genome of endothelial cells may drive the artery or vein to an aberrant ...
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Epigenetic mechanisms in migraine: a promising avenue?
... that epigenetic mechanisms play an important role in disease ...expression, epigenetic processes are also important for programming lasting cellular responses to environmental ...signals. ...
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Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers
... evidence is shedding light on the modulators that remove and/or add methyl marks to histones, pointing toward a new level of plasticity within this epigenetically modifiable system in the development and treatment of ...
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Epigenetic mechanisms in the development and maintenance of dopaminergic neurons
... In order to provide a scalable pool of DA neurons for transplantation purposes in PD patients, continued efforts have been made to direct stem cell reprogramming and differentiation towards the dopaminergic phenotype. ...
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The role of epigenetic mechanisms and processes in autoimmune disorders
... how epigenetic mechanisms could affect the immune system and effector mechanisms in autoimmunity and/or the target organ of autoimmunity and thus affect the development of autoimmune ...to ...
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Epigenetic mechanisms in stress and adaptation
... initiate epigenetic changes, modification of gene expression, memory formation and resulting in adaptive behavioral ...field. Epigenetic mechanisms and their role in memory formation may therefore be ...
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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
... the mechanisms involved in the interplay of DNA methyla- tion, histone modifications, and miRNAs and their cu- mulative effect in the context of T2DM and metabolic memory will significantly contribute to the ...
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Genetic and epigenetic mechanisms of epilepsy: a review
... Common epigenetic mechanisms include DNA methylation, post- translational histone modification, and non-coding ...These epigenetic processes determine not only gene expres- sion or silencing but also ...
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A global assessment of cancer genomic alterations in epigenetic mechanisms
... targeted through alteration of epigenetic mechanisms in cancer. SETD2 is among the most mutated chromatin fac- tors in kidney renal clear cell and lung adeno carcinomas (Table 1). SETD2 trimethylates H3K36, ...
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Transgenerational Epigenetic Mechanisms of Stress Axis Programming
... potential mechanisms that may underlie shifts in offspring stress ...that epigenetic mechanisms are likely involved in reprogramming of the offspring HPA axis circuitry (Seitz et ...
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Epigenetic mechanisms of gene regulation in human breast cancer
... prototype of a gene with typical CpG features, with a large CpG island that spans the promoter and exon 1, encompassing the start site for transcription. CST6 is a member of a family of proteins that represent ...
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Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis
... pressive marks, while H3 lysine-9/14 acetylation (H3KAc) and H3 lysine-4 methylation (H3K4me) are generally acti- vation marks (Figure 14(b)) [50,53,56-59]. The H3Kme is regulated by histone ...
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Epigenetic mechanisms and genome stability
... of epigenetic information during important processes such as X chromo- some inactivation, imprinting, silencing of repetitive ele- ments, transposable elements, and pericentromeric repeats, and developmental gene ...
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Epigenetic mechanisms in virus-induced tumorigenesis
... molecular mechanisms to disrupt specific cellular pathways to facilitate aberrant ...and epigenetic machinery which lead to alterations in the epigenetic landscape of the cell contributing to ...
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Diseases of the oral cavity in light of the newest epigenetic research: Possible implications for stomatology
... main mechanisms of epigenetic regulation include DNA methylation, modifications in histones, and micro-ribonucleic acids ...influencing epigenetic changes, from development to the later stages of ...
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DNA sequence variation and methylation in an arsenic tolerant earthworm population
... methylation patterns with arsenic exposure observed here suggests a potential role of epigenetic mechanisms.. in stress adaptation in earthworms that concur with the evidence available f[r] ...
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Epigenetic regulation of adaptive responses of forest tree species to the environment
... alternative epigenetic states not only triggers the formation of new epialleles but also promotes the movement of DNA trans- posons and retroelements that are very abundant in plant genomes (Mirouze and Paszkowski ...
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From 'omics' to complex disease: a systems biology approach to gene-environment interactions in cancer
... So what is the solution? The primary focus of current oncology research is the identification of SNPs or genetic mutations that predict progression in already existing tumors, or identifying genes and signaling path- ...
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Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy
... other epigenetic mechanisms such as histone modifications, oxidative modification, and non-coding RNA- mediated mechanisms, which are fascinating and pose challenges to the development of ...
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