epigenetic signature
HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia
... commitment–associated epigenetic signature distinguishes human HSC and progenitor cell ...The signature mainly consisted of loci that were sig- nificantly demethylated during commitment from STHSC to ...
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Epigenetic signature of Gleason score and prostate cancer recurrence after radical prostatectomy
... A number of previous studies on DNA methylation biomarkers for predicting PCa outcomes in patients with localized disease have been conducted. Most of these previous investigations focused on specific candidate genes. ...
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Epigenetic signature of differentially methylated genes in cutaneous melanoma
... this epigenetic signature was validated in a larger independent dataset of malignant melanomas from ...DMG signature with Thomas list, we found 10 genes in common (ALOX12, ARHGDIB, COL1A2, EMR3, ...
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A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients
... This study evaluated the methylation profile of triple- negative breast cancer (TNBC) patients treated with neo- adjuvant systemic chemotherapy (NAC) depending on the treatment response and identified a two-gene ...
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Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas
... score signature might be a poten- tial predictive indicator of TMZ outcome and be helpful for identifying subpopulations of patients who are likely to benefit from TMZ ...
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Identification of epigenetic signature associated with alpha thalassemia/mental retardation X-linked syndrome
... Accordingly, in our study, most of the DNA methylation changes observed in patients with an ATRX gene muta- tion were localized at telomeric and pericentromeric regions. How the epigenetic consequences of ATRX ...
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Klengel, Torsten (2016): Epigenetic signature of childhood trauma. Dissertation, LMU München: Fakultät für Biologie
... ical processes and engrave long-lasting epigenetic marks, leading to adverse health outcomes in adulthood. We aimed to elucidate the impact of different early environment on disease-related genome- wide gene ...
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Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes
... Interactions of environmental factors with genetic and epigenetic variants are likely to play an important role in the pathogenesis of type 2 diabetes [9]. Aberrant epigen- etic modifications such as DNA ...
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Epigenome-wide association study for lifetime estrogen exposure identifies an epigenetic signature associated with breast cancer risk.
... lation signature could be identified as an intermediate biological phenotype for the exposure, this might be more accurate measurement than questionnaire-based ...
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Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis
... In this study, we aim to gain insight into innate immune cell dysfunction in CF by investigating alterations in DNA methylation in bronchoalveolar lavage (BAL) cells, composed primarily [r] ...
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The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
... the epigenetic profile can differ substantially between various cell types within a tissue ...of epigenetic changes in fat cell DNA ...cell epigenetic signatures and WAT global transcriptome profiles ...
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Microbiota-sensitive epigenetic signature predicts inflammation in Crohn’s disease
... CD-specific epigenetic marks in the epithelium may be sensitive to the ...methylation signature itself often correlated with a molecular marker of inflammation in ...that epigenetic analyses ...
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Epigenetic signature of preterm birth in adult twins
... gene. Epigenetic alteration of this gene has been shown to medi- ate Alzheimer ’ s disease [38] and dementia ...observed epigenetic modification could result from exposure to complex mixtures of toxic sub- ...
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Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders
... of epigenetic factors in normal ageing (ageing-associated epigenome) and those environmental factors influencing the epigenetic landscape of an organism and that can be more easily modified with lifestyle ...
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Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion
... date, epigenetic mechanisms which act to developmentally regulate gene expression via modifications to DNA, histone proteins and chromatin have not been ...stable epigenetic modification, influencing gene ...
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Unique epigenetic gene profiles define human breast cancers with poor prognosis
... the Epigenetic Signature derived from our qRT- PCR UTSW cohort, in the BRCA-TCGA RNA-Seq as well as the METABRIC datasets [20] that had become publicly ...the Epigenetic Signature genes with ...
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Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome
... (Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer, Stewart et al, Oncotarget), we demonstrated an epigenetic change in the VHL gene upon clear cell renal cancer ...
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Signature Localization and Signature Classification
... has greater complexity and more iterations are required to retrieve a signature. The segmentation of signatures from machine printed documents [8] is processed using conditional random field and the results ...
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Diseases of the oral cavity in light of the newest epigenetic research: Possible implications for stomatology
... of epigenetic regulation include DNA methylation, modifications in histones, and micro-ribonucleic acids ...influencing epigenetic changes, from development to the later stages of ...abuse. ...
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Abstract: Epigenetic regulation plays an important role in gene regulation, and epigenetic markers
... on epigenetic alterations triggered by adverse olfactory experiences showed that the unpleasant acetophenone odor was able to regulate the methylation pattern around the Olfr151 gene, leading to the offspring ...
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