epigenome-wide association studies
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
... Epigenome-wide association studies (EWAS) of human disease are becoming increasingly ...these studies, DNAm levels are measured genome-wide at thousands to millions of sites in ...
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Estimation of a significance threshold for epigenome wide association studies
... Epigenome-wide association studies (EWAS) are designed to characterise population- level epigenetic differences across the genome and link them to ...
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A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome wide association studies
... Previous studies have reported an increased degree of correlation between neighbouring CpG sites (<1 kb dis- tance) [27,28], which are likely to reflect biologically functional ...
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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
... Observational studies show that birth- weight is also associated with later-life health outcomes, including cardio-metabolic and mental health, some cancers and mortal- ity 7–11 ...ome-wide ...
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Twin methodology in epigenetic studies
... epigenetic studies as one of the main tasks in these studies is to find environmental exposures that are associated with the observed epigenetic changes linked to disease ...current ...
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Combining omics data to identify genes associated with allergic rhinitis
... and epigenome-wide association studies and linked marginally significant CpGs located in genes or its promoter and SNPs located 1 Mb from the CpGs, by identifying cis methylation quantitative ...
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Epigenome-wide association study of asthma and wheeze characterizes loci within HK1
... Though DNAm at cg16658191 may, in part, be a marker of high eosinophil counts in adult blood and nRBCs in cord blood, we found that, in addition to the relationship between DNAm and asthma, HK1 expression was strongly ...
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Evaluation of commonly used analysis strategies for epigenome and transcriptome wide association studies through replication of large scale population studies
... previous studies compared different normalization methods [20– ...in association analyses when there was a strong association between CpGs and the exposure of interest ...
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Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
... previous studies that report an association between methylation of cg17901584 ( DHCR24 ) and HDL-C, previ- ous studies reported associations between methylation of this CpG site with waist ...
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Epigenome-wide association study of DNA methylation in panic disorder
... [35] Other EWASs of suicidal behavior or early life stress- associated depression found that the DNA methylation status differed globally between the patients and control subjects [36–38]. In addition, EWASs of ...
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DNA methylation and smoking in Korean adults: epigenome-wide association study
... of association were also ...In studies without cotinine measured, differential methylation at loci correlated with cotinine could serve as objective biomarkers to confirm the self-reported current level of ...
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Epigenome-wide association study of metabolic syndrome in African-American adults
... our epigenome-wide association analysis of MetS and used mixed models to compare methylation of the top CpG sites by MetS and component status adjusting for family structure (R kinship package ...
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Epigenome-wide association data implicates DNA methylation-mediated genetic risk in psoriasis
... panel by using the direct Sanger sequencing. The con- cordance rate between the genotypes from Illumina and Sanger sequencing was 97.6%. We aimed to verify methylation data of cg04087571, cg09914444, and cg06834507 by ...
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Epigenome-wide association study of asthma and wheeze in childhood and adolescence
... Epigenomics Studies; CNS: Centre for neurogenetics and statistical genomics; COPD: Chronic obstructive pulmonary disorder; DAVID: Database for Annotation Visualisation and Integrated Discovery; DMR: Differentially ...
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Epigenome-wide association study of serum cotinine in current smokers reveals novel genetically driven loci
... the studies were as follows: (1) performed in healthy adult human popu- lations (also excluding maternal smoking), (2) sample type analyzed was peripheral blood, (3) studies assessed genome-wide ...
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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
... genetic association and the concept of Mendelian randomisation to investigate the potential causal relationships between DNA methylation in blood and ...genetic association for a causal role of methylation ...
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Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families
... Several studies have shown the possible involvement of HNF1A variants, epistatic interactions with genes in- volved in the very low density lipoprotein pathway and variation within ADIPOQ to be associated with ...
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Epigenome-Wide Association Study of Tic Disorders
... 2008). Studies of brain activity using PET or fMRI in TS subjects compared to controls have implicated dysfunc- tional striatum and thalamus, as well as cortical ...all studies showed significant results, ...
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Controlling bias and inflation in epigenome and transcriptome wide association studies using the empirical null distribution
... simulation studies and large-scale methy- lome (n = 2203) and transcriptome (n = 1910) data [24, 25] to show that correcting inflated test statistics by applying genomic control is too conservative for EWAS and ...
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Epigenome-Wide Association Study of Wellbeing
... strong association with psychological and mental health. Twin-family studies have found that both genotype and environment play an important role in explaining the variance in ...an ...
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