epithelial cell polarity
Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion
... of cell polarity is one of hallmarks for epithelial- mesenchymal transition (EMT) and cancer progression ...breast epithelial cell polarity and cause tumor progression and ...
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Epithelial Cell Polarity Determinant CRB3 in Cancer Development
... alters epithelial cell polarity by repressing the transcription of CRB3 and abolishing the localization of Par and CRB complexes at cell-cell junctions in MDCK cells ...transformed ...
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Epithelial cell polarity and embryo implantation in mammals
... Int I Dc BioI ~O 389 393 (1996) 389 I I I I I I I I I I I I I I I I I I I Epithelial cell polarity and embryo implantation in mammals MICHAEL THIE* PETRA FUCHS and HANS WERNER DENKER Institute of Anat[.] ...
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SEGGA: a toolset for rapid automated analysis of epithelial cell polarity and dynamics
... corresponding cell at the previous or following time points, an error rate comparable to the reported accuracy of other methods (Mosaliganti et ...many cell trajectories are interrupted by segmentation ...
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PAR 3 is required for epithelial cell polarity in the distal spermatheca of C elegans
... From extensive studies, PAR-3 is known to interact with PAR-6 and PKC-3 during cell polarization in various systems. Here we report observations providing evidence that PAR-3, PAR-6 and PKC-3 also work together in ...
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Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes
... The ability to conduct these vectorial processes is dependent on the structural and functional organization of epithelial cells into: a structurally, biochemically, and physiologically d[r] ...
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Genetic studies define MAGUK proteins as regulators of epithelial cell polarity
... edge epithelial (MEE) cells on opposing palatal ...and/or epithelial-to-mesenchyme transformation can cause a cleft palate as has been demonstrated in the TGF- β 3 and EGFR knockout mice (Proetzel et ...and ...
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Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
... Cell polarity, mitotic spindle orientation and asymmetric division play a crucial role in the self-renewal/differentiation of epithelial cells, yet little is known about these processes and the ...
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DLG5 in Cell Polarity Maintenance and Cancer Development
... MAGUKs have evolved from a catalytically ac- tive GUK encoding gene. PDZ and SH3 domains gradually occur during their evolution. MPP and CACNB are first branched off, followed by the branching-off of DLG, ZO and CARMA ...
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TTC7A mutations disrupt intestinal epithelial apicobasal polarity
... in epithelial cell ...pseudostratified cell structures; a low number of villi; and high levels of cell ...of epithelial cells by regulating the RhoA signaling ...Apicobasal ...
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TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field
... dynamic. Cell protrusions have recently been reported in the caudal splanchnic mesoderm of mouse embryos, using phalloidin staining (Sinha et ...in cell intercalation, as mesenchymal SHF progenitors ...
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PAR 3 mediates the initial clustering and apical localization of junction and polarity proteins during C elegans intestinal epithelial cell polarization
... epidermal epithelial cells migrate ventrally to encase the embryo in skin then contract circumferentially to squeeze the embryo and elongate the body axis; simultaneously, the pharynx and intestine form a linked ...
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Coordinating cell polarity: heading in the right direction?
... shaping cell polarization was examined by numerous meeting participants ...anteroposterior cell boundaries drives intercalation by promoting shrinkage of those boundaries until they form four-cell ...
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Prickle/spiny legs isoforms control the polarity of the apical microtubule network in planar cell polarity
... hair polarity whereas pk wings have severely disrupted hair polarity (Gubb et ...of polarity reversal (supplementary material ...of polarity in A-abd and P-abd (Lawrence et ...
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Lethal (2) Giant Larvae: An Indispensable Regulator of Cell Polarity and Cancer Development
... to epithelial tran- sition (MET) ...the cell–cell adhesion molecule and thereby controlling EMT pro- ...of polarity, proliferation and morphol- ogy of human mammary epithelial cells ...
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ROCK1 directed basement membrane positioning coordinates epithelial tissue polarity
... coordinated cell alignment can be rescued by exogenous basement membrane, we propose that the loss of organization in the outer cell layer when ROCK and PAR-1b functions are perturbed is due to the loss of ...
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Tissue specific function of Patj in regulating the Crumbs complex and epithelial polarity
... of epithelial cells, we also looked at the localisation of other polarity ...key polarity determinant is weaker than that observed for Sdt and Crb ...
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A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity
... The N-terminal lysozyme-like domain of SpmX has been shown to be a polar localization determinant for SpmX in Caulobacter (8). Consistent with this result, we show that the SpmX lysozyme-like domain is sufficient for ...
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Molecular mechanisms of cell polarity in fission yeast
... A lot of thanks to the members of the Cell Cycle Lab. Jacky Hay les introduced me to fission yeast, she generously offered me to work together with her on the Tfl retrotranposon project and “volunteered” to read ...
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The conserved transmembrane RING finger protein PLR 1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell surface levels in C elegans
... ALM polarity, wild-type PLM ...PLM polarity defects for independent mec-4::plr-1-yfp ...ALM polarity defect of cwn-1; egl-20 animals is 38% and PLM polarity defect of lin-44 mutants is 80% ...
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