EPITOPE SPECIFIC CLASS I HLA-SPECIFIC
HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B*57 That Is Distinct from HLA-B*58:01
... MHC class I assembly and peptide ...Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, et ...affect HLA class I peptide ...
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HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control
... incomplete. HLA-B*57 alleles and the closely related HLA-B*5801 are often grouped together because of their similar peptide-binding motifs and HIV disease outcome ...between HLA-B*57 alleles, termed ...
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T-Cell Tolerance for Variability in an HLA Class I-Presented Influenza A Virus Epitope
... with HLA-B*0702 binding ...to HLA-B*0702 correlated with the NP 418–426 -specific IFN- ␥ T- cell responses observed above; it is possible that NP 418–426 peptides exhibiting a higher affinity for ...
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Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope
... the HLA class I ...to HLA-B*35 expression, in particular to the less common HLA-B*3502 and HLA-B*3503 sub- types but also to the most prevalent subtype, ...whereas ...
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CD8+ T cells specific for a potential HLA-A*0201 epitope from Chlamydophila pneumoniae are present in the PBMCs from infected patients
... H2-class I epitopes, neither our group (13) nor Wizel et ...potential epitope could not be addressed using our in vitro ...CTLs specific for a Cpn-peptide can recognize non-infected ...
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Predicting the affinity of epitope-peptides with class I MHC molecule HLA-A*0201: an application of amino acid-based peptide prediction
... (MHC) class I pathway (Buus, 1999; Brunak and Buus, ...a specific antigen is thus the administration of the peptides derived from this antigen that are recognized by MHC class ...so-called ...
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A Mutation in the HLA-B*2705-Restricted NP383-391 Epitope Affects the Human Influenza A Virus-Specific Cytotoxic T-Lymphocyte Response In Vitro
... MHC class I peptide complexes on the surface of these cells were on the same order of magnitude when a CTL clone specific for the M1 58–66 epi- tope was ...383–391 epitope in influenza viruses ...
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Relative Dominance of Epitope-Specific Cytotoxic T-Lymphocyte Responses in Human Immunodeficiency Virus Type 1-Infected Persons with Shared HLA Alleles
... three HLA class I alleles shared by all of the ...subject’s HLA class I unmatched B allele in order to gain a more compre- hensive view of the total HIV-1-specific CTL ...
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Lassa Fever Virus Peptides Predicted by Computational Analysis Induce Epitope-Specific Cytotoxic-T-Lymphocyte Responses in HLA-A2.1 Transgenic Mice
... MHC class I allele-specific LV binding motifs has con- firmed the existence of three epitopes capable of generating peptide-specific CTL ...in HLA-A2 trans- genic mice. This is the ...
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Towards HLA epitope matching in clinical transplantation
... on HLA-A, -B and -DR matching at the antigen level, one should realise that HLA antibodies are not specific for antigens, but recognise B cell epitopes present on HLA ...of HLA ...
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Differential Escape Patterns within the Dominant HLA-B*57:03-Restricted HIV Gag Epitope Reflect Distinct Clade-Specific Functional Constraints
... IMPORTANCE HLA-B*57 is the HLA class I molecule that affords the greatest protection against disease progression in HIV ...the HLA associations with differential HIV disease outcome, ...
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Detection of HLA class I-specific antibodies by the QuikScreen enzyme-linked immunosorbent assay.
... IgA, and IgM and the other specific for only IgG, were used in the course of our clinical testing. We found the anti-IgG re- agent to be more sensitive and more reliable than the anti- IgGAM reagent. In tests of ...
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Characterisation of HLA specific antibodies
... target HLA proteins are purified and attached to polystyrene beads [114, 115], the beads themselves are individually labeled with specific ratios of fluorescent marker ...any HLA- specific ...
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Activation and detection of HTLV I Tax specific CTLs by Epitope expressing Single Chain Trimers of MHC Class I in a rat model
... HTLV- I-infected rat revealed that ...antigen- specific T-cell screening systems, we have stimulated the splenocytes with Tax180-188 or NLEnv371-379 peptides and examined IFN-γ production in the ...was ...
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Mapping of Escherichia coli H27-Specific Epitope from H-Specific Polypeptides
... Forty-nine partially purified native H-type flagellins were used to evaluate the specificity of the MAb. The fliC gene of H27 is 1,464 bp in length (487 amino acids [aa]; 50.88 kDa). The central variable region (CVR) of ...
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Associations of HLA alleles with specific language impairment
... of HLA loci in SLI. Quantitative association analyses highlighted HLA-A and parent-of-origin effects for HLA- B , whereas case-control analyses implicated HLA-DRB1 ...imputed HLA ...
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Biophysical characterisation and profile of HLA specific antibodies in transplantation
... help, I would have not achieved the goal set in this project. Firstly, I would like to thank my initial supervisor Dr Daniel Zehnder who had trusted and believed I could achieve the ...
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Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes
... earlier epitope expression and MHC-I downregulation by Nef to the antiviral activity of ...that epitope kinetics play an important role, when comparing Nef-defective viruses express- ing SL9 late or ...
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Direct quantitative measurement of the kinetics of HLA specific antibody interactions with isolated HLA proteins
... monoclonal, HLA-specific ...different HLA antibody/HLA allele combinations, in the order of ...expected HLA specificity and we can discern a distinct signal for low nanomolar ...
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HLA class I restricted cytotoxic T lymphocytes specific for hepatitis C virus Identification of multiple epitopes and characterization of patterns of cytokine release
... the HLA class I molecules A2, A3, A11, A23, B7, B8, and ...to HLA class I molecules, although in some cases we have identified CTL epitopes for which no published motif ...and ...
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