ER-associated protein degradation
Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation
... in ER stress ...the ER when protein load overwhelms the ER folding capacity. ER stress is sensed by three ER transmembrane receptors, including the double-stranded RNA ...
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GPG NH2acts via the metabolite αHGA to target HIV 1 Env to the ER associated protein degradation pathway
... ER-associated protein degradation (ERAD) ...the ER quality control machinery to recognize gp160 as terminally misfolded and results in its retro-translocation to the ...its ...
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Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age associated obesity
... the ER chaperone BiP (Supplemental Figure ...Hrd1 protein levels were significantly increased in POMC neurons in the ARC in response to refeeding following an overnight fast, but were not increased in ...
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Braun, Sigurd (2005): ER-associated degradation (ERAD): Novel components and cellular regulation. Dissertation, LMU München: Fakultät für Biologie
... their degradation. The endoplasmic reticulum (ER) forms a specialized compartment for protein folding and maturation and about 20% of the human genes have been predicted to encode for secretory ...
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Membrane Heredity Composed by Symbiogenesis
... eukaryotic protein translocation machineries reveals the real ingenuity of symbiogenetic ...eukaryotic protein translocation molecular assemblies in eukaryotes: (i) the ER-associated ...
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ER associated degradation is required for vasopressin prohormone processing and systemic water homeostasis
... the ER but remains function- al to sense misfolded ER proteins in ERAD-deficient ...the ER and leads to an increased level of functional proteins at the cell surface of ERAD-deficient cells ...the ...
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NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer
... density-95 protein (PSD-95) enhanced Mas protein level by increasing its stability ...PDZ protein, CAL, inhibited degradation of metabotropic glutamate receptor 5a and β1- adrenergic receptor ...
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Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels
... situ; ER: Estrogen receptor; ERAD: Endoplasmic reticulum- associated degradation; FACS: Fluorescence Activated Cell Sorter; GSEA: Gene Set Enrichment Analysis; HER2: Human epidermal growth factor ...
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... death-associated protein kinase 1; eIF2 α : eukaryotic translation initiation factor 2 α ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory ...
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Human Cytomegalovirus Infection Activates and Regulates the Unfolded Protein Response
... induce ER stress are faced with the conse- quences of UPR activation, some of which can be detrimental to viral ...in ER stress-associated degradation and may hamper viral replication by ...
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Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO
... ABSTRACT UL148 is a viral endoplasmic reticulum (ER)-resident glycoprotein that contributes to human cytomegalovirus (HCMV) cell tropism. The influence of UL148 on tropism correlates with its potential to promote ...
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Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C elegans muscle
... autophagic protein degradation is the type of protein degradation most commonly triggered in response to knockdown of any individual kinase or phos- phatase, we have found that functional ...
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The transcription factor X-box binding protein-1 in neurodegenerative diseases
... Huntingtin protein (Htt) ...Htt protein impair several physiological functions of the ...However, ER stress and UPR activation have been re- ported in HD models and markers of these two pathways have ...
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Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation
... [22-27]. ER is a vital cellular organelle required for protein folding and ...the ER results in ER stress triggers the un- folded protein response ...activating ER stress [22, ...
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An Updated Review On Anticancer Activity Of Capsaicin
... was associated with down-regulation of sirtuin 1 (SIRT1) deacetylase, possibly through proteasome-mediated protein ...and protein degradation diminished the deacetylase of SIRT1, which in ...
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Of yeast, mice and men: MAMs come in two flavors
... an ER-mitochondria di- meric split green fluorescent protein” (Alford et ...the ER, which most studies do not account ...of ER stress, in absolute dependence on PERK (Munoz et ...Since ...
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Progesterone receptors animal models and cell signaling in breast cancer: Role of steroid receptor coactivators and corepressors of progesterone receptors in breast cancer
... Nuclear receptor corepressor (N-CoR) and silencing mediator of retinoid and thyroid receptor (SMRT) are both corepressors of numerous transcription factors, including steroid hormone receptors. Both N-CoR and SMRT ...
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Giant axonal neuropathy–associated gigaxonin mutations impair intermediate filament protein degradation
... IF protein might be cleared by gigaxonin in patients with Alexander disease ...IF protein degradation, it is possible that excess expression of gigaxonin may have side effects that we have been ...
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Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case control study
... Methods We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, ...
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Protein kinase CK2 in the ER stress response
... The ER is responsible for the synthesis, folding, post-translational modification and quality control of numerous secreted and membrane pro- ...the ER are influenced by Ca 2+ ion concentration in the ...
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