ERK/AKT signaling pathway
Original Article PAR-2 promotes invasion and migration of esophageal cancer cells by activating MEK/ERK and PI3K/Akt signaling pathway
... Cells were washed three times with pre-cooled PBS and lysed in protein extraction reagent (RIPA: PMSF = 100:1) for 30 min. After centrifu- gation at 12,000 rpm for 10 min at 4°C, the supernatant was collected as total ...
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Gemcitabine resistance in breast cancer cells regulated by PI3K/AKT-mediated cellular proliferation exerts negative feedback via the MEK/MAPK and mTOR pathways
... (MEK)/MAPK signaling pathways were activated through elevated expression of phosphorylated (p)-extracellular signal-regulated kinase (ERK), p-AKT, mTOR, p-mTOR, p-P70S6K, and reduced expression of ...
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Original Article Propranolol induces apoptosis in endothelial cells by inhibiting Akt and ERK phosphorylation and MAPK signaling pathway
... of Akt and ERK through β-ADR ...up-regulated Akt and ERK phosphoryla- tion by ...of Akt and ERK phosphorylation via the β-ADR ...inhibited Akt and ERK ...
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Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... ticular tumor microenvironment, the autophagy performed a complex dual roles during the anti- cancer treatment [17, 18]. On the one hand, autophagy as a tumor suppressor, it can be a negative regulator of tumor formation ...
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Original Article Baicalein suppresses EGF-induced proliferation and migration of glioma cells via EGFR/Akt signaling pathways
... EGFR/Akt signaling pathways are hyperactive in a variety of cancers ...as Akt (protein kinase B), giving rise to cell prolif- eration and promoting cell survival by suspend- ing ...naling ...
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Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
... Ras-ERK signaling pathway are limited due to adaptive resistance of tumor ...Ras-ERK pathway can result in activation of the PI3K-AKT pathway, thereby diminishing the ...
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Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target
... RAS signaling in AML blasts ...PI3K/AKT pathway, L-744832 targeting RAS, PD98059 targeting ERK/MAPK signaling and AG1296 targeting FLT3, the authors found that NF- κB DNA-binding ...
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Effect of Testosterone on Memory and BDNF Levels of Hippocampus in Gonadectomized Diabetic Rats
... the signaling pathway of angiogenesis in sciatic nerve( AKT/ERK ...and ERK proteins were ...decreased Akt protein in the diabetic and diabetic gonadectomized groupssignificantly ...
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EGR1 mediates miR-203a suppress the hepatocellular carcinoma cells progression by targeting HOXD3 through EGFR signaling pathway
... Using quantitative real-time PCR (qRT-PCR), we found lower expression of EGR1 mRNA levels in HCC tissues, compared with their respective healthy tissues (Figure 1A). The levels of miR-203a were correlated with EGR1 ...
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Targeting AKT/mTOR and ERK MAPK signaling inhibits hormone refractory prostate cancer in a preclinical mouse model
... AKT/mTOR pathway activation is associated with human prostate cancer progression and correlated with activation of ERK ...the AKT/mTOR signaling pathway in human normal and ...
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Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
... To explore the potential mechanism by which pectolinarigenin induced HCC cell proliferation, we conducted Western blot to investigate the potential molecular targets of pectolinari- genin. The results indicated that ...
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Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects
... mTOR may be regulated through another pathway in SPC-treated Mel-Ab cells. In previous studies, it has been reported that mTOR was activated by phospholipase D1 (PLD1), which plays a negative regulatory role in ...
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Original Article CXCR4 was involved in andrographolide inhibits atherosclerosis by inactivating the PI3K/AKT/NF-κB signaling pathway
... The results above verified andro plays a protec- tive role, the following test will investigate the related pathways of CXCR4 regulation. In this part of research, realtime-PCR and western blot were applied to detect the ...
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Localization of ERK/MAP Kinase Is Regulated by the Alphaherpesvirus Tegument Protein Us2
... kinase signaling pathway during infection and require ERK activation for the efficient execution of their replication ...identified ERK as a Us2-interacting ...to ERK in virus-infected ...
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TWEAK/Fn14 interaction regulates RANTES production, BMP 2 induced differentiation, and RANKL expression in mouse osteoblastic MC3T3 E1 cells
... PI3K-Akt pathway, inhibited BMP-2-induced differentiation through the MAPK Erk pathway, and upregulated RANKL expression through the MAPK Erk pathway in osteoblastic MC3T3-E1 ...
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Exploring the pathogenetic association between schizophrenia and type 2 diabetes mellitus diseases based on pathway analysis
... Wnt signaling pathway plays a role in the development of central nervous system (CNS) [14], and has been also associated with SCZ [15,16], TCF7L2 may contribute to the co-morbidity of SCZ and T2D through ...
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PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis
... the AKT pathway significantly upregulates T-box 3, a known transcriptional repressor that interacts with the pluripotency factors NANOG and OCT4 to pro- mote the maintenance of pluripotency [21, ...the ...
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<p>MicroRNA-145 inhibits growth of laryngeal squamous cell carcinoma by targeting the PI3K/Akt signaling pathway</p>
... Zhao et al, 17 analyzed miR-145 and MYO5A expres- sion in 132 patients with LSCC, and evaluated associa- tions between this expression and clinicopathological features. They observed a regulatory relationship between ...
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<p>Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas</p>
... MAPK, AKT is another signaling pathway that plays a critical role in the progression of uterine leio- ...and AKT signaling pathway was related with mifepristone inhibition on ...
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The Mechanism Study of Dracocephalum Moldavica L. Total Flavonoids on Apoptosis induced by Myocardial Ischemia/Reperfusion injury in vivo and in vitro
... Dracocephalum moldavica L. is a commonly medicinal plant of Uygur and Mongolian nationalities and has a medicinal history for hundreds of years. It has been confirmed to have protective effects against myocardial ...
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