ERK inhibitor
ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... JNK/ ERK/p38 MAPK phosphorylation, and PARP cleavage in cultured primary ...JNK inhibitor (SP600125), but not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), significantly ...
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Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep
... and Erk pathways would decrease fol- licle growth and oestradiol production by ovine ovarian follicles in ...Akt inhibitor (n = 5; follicle injected with LY294002 in control medium), Erk ...
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Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression
... the ERK pathway and increased phosphorylation of CREB at Ser-133 in both ...MEK/ERK inhibitor, AZD6244, dramatically inhibited the ERK pathway, reduced CREB phosphorylation and decreased the ...
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ERK2 phosphorylation of EBNA1 serine 383 residue is important for EBNA1-dependent transactivation
... Functional inhibition of Epstein-Barr virus (EBV)-encoded nuclear antigen 1 (EBNA1) can cause the death of EBV infected cells. In this study, a bioinformatics tool predicted the existence of putative extracellular ...
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Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte
... the ERK and AKT signaling pathways were found to be involved in TDPN induction of EMT, as evi- denced by the induction of phosphorylation of ERK and AKT which was confirmed by pretreatment AKT ...
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Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis
... Previous studies have focused mainly on the RAS-RAF-MEK-ERK pathway in cancer cells. However, p-ERK1/2 expression has been shown prognostic and metastatic implications in PDAC [40, 41]. Our result showed HMPDAC ...
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PubMedCentral-PMC5726788.pdf
... MEK inhibitor trametinib 2.1ppm (Tram), the PI3K beta inhibitor GSK231418 ...the ERK inhibitor BVD-523 50mg/kg twice daily oral gavage, the MDM2 inhibitor CGM097 100mg/kg once daily ...
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Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells
... contrast, ERK inhibitor PD98059 and ERK siRNA enhanced TF promoter activity by ...EGFR inhibitor erlotinib and EGFR siRNA also significantly suppressed PD98059- or ERK siRNA-induced TF ...
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ZNF259 promotes breast cancer cells invasion and migration via ERK/GSK3β/snail signaling
... Results: ZNF259 expression was much higher in breast cancer cells than in the adjacent normal breast duct glandular epithelial cells (75.94% vs 7.52%, P<0.001) and was closely related to the breast cancer patients’ ...
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Regulatory role of heme oxygenase-1 in silica-induced lung injury
... the ERK inhibitor, U0126, 2 h before and 6 h after silica administration showed attenuated HO-1 in- duction in the lungs (Additional file ...activated ERK was significantly higher in silicosis mice ...
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Dihydrotestosterone induces SREBP-1 expression and lipogenesis through the phosphoinositide 3-kinase/Akt pathway in HaCaT cells
... the ERK inhibitor PD98059 could reverse the activation of p-Akt and p-ERK (Figure 1-A), respectively, and their effects on DHT- induced SREBP-1c expression were different: LY294002 inhibited the ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
... Akt inhibitor MK-2206 and the dual EGFR/ HER2 inhibitor lapatinib is in progress with patients having advanced or metastatic solid tumors or breast cancer ...EGFR inhibitor erlotinib, docetaxel, or ...
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Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
... PDGF has long been implicated in the development of BM fibrosis in MPN along with TGF-β and bFGF (57, 69, 70). Mainly produced by megakaryocytes, PDGF is primarily stored and released from α granules in megakaryocytes ...
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
... from ERK which can inhibit Raf and ...single inhibitor which targets both molecules, such as the new PI3K and mTOR dual inhibitors this becomes a realistic therapeutic ...
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Role of the Serine-Threonine Kinase PAK-1 in Myxoma Virus Replication
... Previously, it has been shown that poxvirus infection of mammalian cells is associated with dramatic and rapid cell signaling events that induce the activation of distinct species of cellular signaling molecules, ...
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SORAFENIB-MULTIKINASE INHIBITOR FOR ADVANCED RENAL CELL CARCINOMA
... multikinase inhibitor, targeting the Raf/Mek/Erk pathway showed promising results by prolonging progression-free survival in patients with advanced renal cell carcinoma in whom previous therapy had failed, ...
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Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development
... matrix; ERK: extracellular signal-regulated kinase; IHC: immunohistochemistry; HCC: hepatocellular carcinoma; HSCs: hepatic stellate cells; MAMs: metastasis-associated macrophages; MAPK: mitogen-activated protein ...
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ERK-MAPK Signaling Opposes Rho-Kinase to Reduce Cardiomyocyte Apoptosis in Heart Ischemic Preconditioning
... ing cell contraction, dynamic membrane blebbing, nuclear disintegration and frag- mentation of apoptotic cells into apoptotic bodies. Previous studies have demon- strated that I/R upregulates expression of RhoA in ...
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Dioscin overcome TKI resistance in EGFR-mutated lung adenocarcinoma cells via down-regulation of tyrosine phosphatase SHP2 expression
... expression of Bcl-2, Bcl-w, Bcl-xL, but elevated the expression of Bim and Bax in CL97 and H1975 cells when compared both cells without dioscin treatment (Supplementary Figure 2). These results were partially consistent ...
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Original Article Molecular mechanism of ERK signal pathway in cell autophagy
... This study utilized gastric carcinoma cell line SGC-7901 as the model, on which regulatory role of rapamycin and possible mechanisms were studies from both molecular and protein levels. Data showed that rapamycin ...
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