ERK/p38
<p>m<sup>6</sup>A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways</p>
... metastasis in different cancer types. 19–21 In this study, p-P38 and p-ERK were activated in the METTL3 knock- down group. Whereas, the expression levels of p-P38 and p-ERK were lower in ...
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Role of Rac1/p38 and ERK Dependent Cytosolic Phospholipase A2 Activation in Porphyromonas gingivalis Evoked Induction in Matrix Metalloproteinase 9 (MMP 9) Release by Salivary Gland Cells
... for 10 min, and the supernatants were subjected to protein determination using BCA protein assay kit (Pierce). The lysates of whole cells as well as those of membrane preparations were then used either for immunoblots ...
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Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer
... and p38 MAPK, resulting in regulation of the activities of transcription factors, such as activator protein-1 (AP-1) and nuclear factor kappa B (NF- κB), which in turn modulate the expression of metastasis- ...
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“Docking Studies on Eupalitin-3-O-β-D-galactopyranoside as Potential Inhibitor of Cyprinus carpio (KOI CARP) MAPK/ERK Kinase 2 and Mitogen-Activated Protein Kinase (p38)” by Kader Asen Fathima, Chetancherry Somasundaram Parameswari, India.
... and p38 MAPKinase in TNF-α signalling was ...diseases. p38 alpha is a key MAPK involved in tumor necrosis factor alpha and other cytokine ...particular p38 MAPK, and their involvement in the ...
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Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes
... Methods: Experiments were performed in Hepa-1c1c7 and HepG2 cells. The quinone reductase (QR) activity assay was used to assess the activity of physalin A and other compounds isolated from P. alkekengi. The antioxidant ...
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Anti osteoclastogenic activity of matairesinol via suppression of p38/ERK NFATc1 signaling axis
... of p38 in modulating NFATc1 expression during ...the ERK pathway in osteoclast differentiation has received much attention; ERK can trig- ger activation of c-Fos-NFATc1 for osteoclastogenesis, and ...
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Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK
... vates ERK and p38 MAPK in primary astrocytes (see [21] and this ...that p38, but not ERK, mediated the upregulation of Nrf2 and HO-1 by andrographolide, while in endothelial cells, although ...
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Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain
... (ERK), p38, and c-Jun N-terminal kinase (JNK) ...in ERK activity is mainly distributed in neurons, while JNK activation is mainly reflected in astrocytes, and p38 activation is mainly ...
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MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells
... cells. ERK-, p38-, and JNK-specific inhibitors were all shown to upregulate the expression of FoxA2 significantly, as well as that of E-cadherin, providing further evidence that the ERK-, ...
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ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... JNK/ ERK/p38 MAPK phosphorylation, and PARP cleavage in cultured primary ...not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), significantly reduced ZnO NP-induced cleaved PARP and ...
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The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide
... both ERK-1/2 and p38 MAPK phosphorylation, which was reduced by NaSH in both the non-smoker and smoker ASM cells, but no effect was seen in the COPD ...
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Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern recognition receptors
... in suppressing LPS-induced TNF-α production (see Additional file 3). As shown in Figure 3C, TNF-α pro- duction was significantly inhibited by U0126, SB202190, and SP600125, indicating that PS-F2-triggered activa- tion of ...
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Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism
... of p38 mitogen-activated protein kinase (MAPK) signaling was able to significantly inhibit replication by all viruses ...virus-mediated p38 and extracellular signal-regulated kinase (ERK) MAPK ...
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Original Article p38 regulates mRNA stability of cytokines stimulated by Zymosan A
... i.e., p38 inhibitor SB202190, ERK inhibitor PD98059, and JNK inhibitor SP600125, to block the targeted pro- tein kinase, and then were stimulated with Zymosan A (100 ng/mL) and LPS (10 ng/mL) for 60 ...
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Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression
... [115]), p38 (SB203580;10 μM; Tocris; [116]), ERK (SL327, 50 μM; Tocris; [117]) or FAK (PF573228; 10 μM; Tocris; [118]) were incubated with C6 cells for 4 hours, 24 hours after initial ...
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Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase
... Phosphorylation of p38 MAPK (Thr180/Tyr182) and ERK-1,2 (Thr202/Tyr204) was assayed using corre- sponding cell-base ELISA kits (R&D Systems). Confluent HUVECs grown on a 96-well cell culture ...
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Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction
... ylated p38-MAPK but not ERK1/2 in thoracic ...phosphorylated ERK 1/ 2 in thoracic aorta post 28-days ...although p38-MAPK was not altered post 14-days diabetic group, ERK1/2 is ...both p38- ...
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12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... DRG. Interestingly, spinal cord p38 MAPK, ERK, and SAPK/JNK phosphorylation induced by diabetes, ap- peared independent of the LO mechanism. In the present study, similar findings in peripheral nerve and ...
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Modulation of cancer signalling pathway(s) in two stage mouse skin tumorigenesis by annonacin
... Two-stage skin cancer model consists of multistage tumorigenesis, offers an investigational framework to study the basic mechanism linked with the initiation, pro- motion and progression stages in animal. It is also ...
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Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart
... and p38-MAPK). Furthermore, activation of p38- MAPK stimulates phosphorylation of MAPKAPK2, which in turn phosphorylates the HSP27, possibly leading to cell ...of p38-MAPK and HSP27 is ...of ...
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