ERK phosphorylation
ERK phosphorylation of MED14 in promoter complexes during mitogen induced gene activation by Elk 1
... and phosphorylation-dependent inter- action of Elk-1 with co-activators, including histone acetyltransferases and the Mediator ...recruits ERK to the promoters of its target genes, suggesting that ...
13
Helicobacter pyloriInduction in Gastric Mucosal Prostaglandin and Nitric Oxide Generation Is Dependent on MAPK/ERK Mediated Activation of IKK β and cPLA2: Modulatory Effect of Ghrelin
... in ERK activation and further enhanced by ghrelin, was associ- ated with IKK-β phosphorylation, and the inhibitory ef- fect of PD98059 on ERK phosphorylation was also re- flected in a reduced ...
11
Rittiner_unc_0153D_14110.pdf
... Carbachol-evoked phosphorylation of ERK is mediated by PKCδ in HEK293 cells ...in ERK phosphorylation was modest (approximately 20%), but statistically significant (p < ...in ERK ...
163
Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway
... I A was unlikely induced by ERK phosphorylation, be- cause the CCK-8 application did not change the ERK ac- tivity in DRG cells, whereas the levels of p -JNK were significantly increased[r] ...
15
L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor
... We next examined ligand-dependent interaction between GPR143 and ADRA1B. The immunopre- cipitation assay revealed that L-DOPA (10 nM) enhanced the interaction between ADRA1B and GPR143 in HEK293 cells coexpressing ...
17
Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways
... MAPK-ERK phosphorylation was increased at low heparin concentrations when the cell cultures were stimulated by hFGF, while unstimulated cultures were inhibited ...
12
Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
... prevents ERK activation and provides superior therapeutic efficacy in a Jak2V617F MPN mouse ...to ERK inhibitors, which are less well characterized, several MEK inhibitors have been clini- cally tested in ...
17
Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma
... interaction was further analyzed by confocal immunofluorescence microscopy in HCC cells (Figure 5E). The adapter CRKL was composed of an N-terminal SH2 domain and two SH3 domains, SH3N and SH3C. To address which domain ...
15
Two highly related regulatory subunits of PP2A exert opposite effects on TGF β/Activin/Nodal signalling
... C-terminal phosphorylation (Massagué et ...Smad2 phosphorylation in whole embryos in response to endogenous Nodal signalling, whereas overexpression of B α had no effect ...Smad2 phosphorylation was ...
11
Phosphorylation of Beta 3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
... of ERK ’ s effects on lipolysis in ...mouse ERK activation with HFD-induced obesity, we also observed elevated ERK phosphorylation in the fat body following a high-sugar diet that causes ...
14
Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP)
... the phosphorylation of ERK1/2, JNK, p38 by Western blot to confirm whether DBP will interfere with MAPKs signaling ...JNK, ERK phosphorylation level was significantly increased, and P38 ...
10
Comparison of MAPK specificity across the ETS transcription factor family identifies a high-affinity ERK interaction required for ERG function in prostate cells
... discovered ERK phosphorylation of S215 in ERG, and a specific antibody confirmed that this phosphorylation event occurs in vivo (Figure ...this phosphorylation event was re- quired for ERG to ...
14
Helicobacter pylori Induction in Gastric Mucosal Prostaglandin and Nitric Oxide Generation Is Dependent on MAPK/ERK Mediated Activation of IKK β and cPLA2: Modulatory Effect of Ghrelin
... in ERK activation and further enhanced by ghrelin, was associ- ated with IKK-β phosphorylation, and the inhibitory ef- fect of PD98059 on ERK phosphorylation was also re- flected in a reduced ...
11
Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth
... and ERK phosphorylation to upregulate ID1 expression and mildly suppressed proliferation over a 24-hour period (Figure 8B, Supplemental Figure 7, A, B, D, F, and Supplemental Figure ...markers, ...
17
Phosphorylation of the Human Papillomavirus Type 16 E1^E4 Protein at T57 by ERK Triggers a Structural Change That Enhances Keratin Binding and Protein Stability
... T57 phosphorylation reflects the enhanced ability to bind to kera- tins, WT 16E1 E4 was expressed in the isogenic cell line pair Cl2 and T7K; these cell lines differ from each other only in the presence of a ...
16
CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model
... to ERK signaling in HEK-293 ...stimulated ERK, AKT and mTOR phosphorylation, promoted cell proliferation and migration, and upregulated genes regulating testosterone ...
13
Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
... To explore the potential mechanism by which pectolinarigenin induced HCC cell proliferation, we conducted Western blot to investigate the potential molecular targets of pectolinari- genin. The results indicated that ...
10
Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization
... neovascularization. As the neurotransmitter dopamine (DA) modulates adult endothelial cell function, we hypothesized that DA might have a regulatory role in mobilization of EPCs from the bone marrow niche. We show that ...
11
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling
... (9101), ERK (9102), AKT (9272), JNK (9252), pJNK (9251) (all from Cell Signaling); complex I (A21344), complex II (A21345), complex III (A21362), complex V (A21350), p-Y612-IRS1 (44816G) (all from Invitrogen); ...
15
A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets
... that ERK signaling is not involved in the early signaling that is required for endoderm induction, which occurs at a time when MAPK activation was not significantly ...
14