ERK1/2 Signal Pathway
<p>Sennoside A Induces GLP-1 Secretion Through Activation of the ERK1/2 Pathway in L-Cells</p>
... Purpose: Glucagon-like peptide-1 (GLP-1) is secreted from the intestinal L-cells to stimulate insulin secretion in the blood glucose control. Our previous study indicates that Sennoside A (SA) can increase the plasma ...
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ERK1/2 and MEK1/2 Induced by Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Early during Infection of Target Cells Are Essential for Expression of Viral Genes and for Establishment of Infection
... extracellular signal-regulated kinase 1 and 2 (ERK1/2) via the PI3K-PKC -MEK ...by 2 h and 4 h ...of ERK1/2 by KSHV and KSHV envelope glycoproteins gB and ...significant ...
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ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
... activated ERK1/2 (pERK), this point needed to be further ...for ERK1/2 interaction called the D domain was present close to S323 between amino acids 353 and 364 of TRF2 (KNKRMTISRLVL) [32] ...
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MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
... and ERK1/2 inhibit self-renew of liver tumor cells and HCC initiation partly through the transcription factor c-Myc which is a down- stream target gene of ERK1/2 ...and signal pathways ...
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Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
... extracellular signal-regulated kinase 1/2 (ERK1/2), c- Jun N-terminal kinases 1-3 (JNK1-3), and p38 iso- forms (p38α, β, γ, and δ), which have previously been reported to be controlled by the ...
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Reciprocal Regulation of AKT and MAP Kinase Dictates Virus-Host Cell Fusion
... q pathway to trigger HIV-1-induced cell- cell fusion ...Extracellular signal-regulated kinases 1 and 2 (ERK1/2), which mediate diverse specific responses to various stimuli, such as ...
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Visfatin Promotes Wound Healing Through the Activation of ERK1/2 and JNK1/2 Pathway
... extracellular signal-regulated kinases 1 and 2 (ERK1/2) and c-Jun N-terminal kinases 1 and 2 (JNK1/2) in a time-dependent ...of ERK1/2 and JNK1/2 led to a ...
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Negative feedback regulation of the ERK1/2 MAPK pathway
... example, ERK1/2 MAPKs can phosphorylate the epidermal growth factor (EGF) receptor (EGFR) at T669 [7, 8], the major site of Ser/Thr phosphorylation of the ...on ERK1/2 activity and was ...
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Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation
... of ERK1/ 2, which likely plays a role in pathogenesis of cardiomy- opathy ...signaling pathway occurs in skeletal muscle. We therefore examined ERK1/2 activity in skel- etal muscle from ...
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Epstein-Barr Virus Latent Membrane Protein 2A Promotes Invasion of Nasopharyngeal Carcinoma Cells through ERK/Fra-1-Mediated Induction of Matrix Metalloproteinase 9
... a signal regulator, LMP2A can enhance inva- siveness and motility of epithelial ...LMP2A-activated ERK1/2 pathway, and induction of the ERK1/2–Fra-1–MMP9 axis required PY motifs ...
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Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation.
... (MAPK1/2)–extracellular signal-regulated kinase1/2 (ERK1/2) pathway is known to play an important role in cell survival, migration and angiogenesis during wound healing, 18-20 ...
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Original Article Salidroside induces apoptosis via ERK1/2 in human leukemia K562 cells
... of ERK1/2 was also ...of ERK1/2 signaling pathway in human leukemia K562 cells and may be a promising candidate for leukemia ...
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Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2
... AsPC1 and HPD1NR cells were cultured with RV or AC for 24 hours, and we used AKT inhibitor VIII and U0126 (Calbiochem) as specific inhibitors. Cell monolayers were rinsed thrice with ice-cold PBS (Sigma) and prepared ...
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CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms
... ROCK inhibitor Y-27632, the MAPK/ERK kinase 1 (MEK1) inhibitor U0126 for the designated time points. The cells were then washed in PBS and suspended in 100 μl of RIPA buffer (Pierce). Supernatant protein concentrations ...
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Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer
... cascades, ERK1/2 is considered an attractive target for developing therapeutics against cancers due to its significant pharmacological specificity and selectivity ...the ERK1/2 signaling ...
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High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells
... different signal strengths in individual cancers is not only of interest to learn more about these still poorly grasped diseases, it may eventually also impact on the therapeutic use of signal transduction- ...
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Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells
... conserved pathway in cells, and just a few oncogenic mutations have been discovered in human cancers to date ...Hippo pathway in cancer cells could lead to new therapeutic ...signals, ERK1/2 ...
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Maleylated BSA induces TNF α production through the ERK and NF κB signaling pathways in murine RAW264 7 macrophages
... However, the reason why each SR ligand elicits dis- tinct inflammatory reactions has not yet been clearly identified. For example, fucoidan, a negatively charged polysaccharide, induces nitric oxide (NO) production via ...
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Proteomics Analysis of the Expression of Neurogranin in Murine Neuroblastoma (Neuro-2a) Cells Reveals Its Involvement for Cell Differentiation
... Neuro-2a and HEK293 cells were grown in 10 cm Petri-dishes and were washed with ice cold PBS twice. The cells were lysed with modified RIPA buffer which contained: 50 mM Tris-HCl pH7.4, 0.25% Na-deoxycholate, 150 mM ...
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miR-144/451 cluster plays an oncogenic role in esophageal cancer by inhibiting cell invasion
... Results: Overexpression of miR-144-3p promoted early apoptosis of ECa9706 and inhibited cell migration, cell inva- sion and cell proliferation. miR-144-5p and miR-451a inhibited cell proliferation, at the same time, ...
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