ERK1/2 signaling pathway
Original Article CGRP inhibits vascular smooth muscle cell proliferation through suppressing ERK1/2 signaling pathway
... and ERK1/2 phosphorylation were tested by Western ...0.05). ERK1/2 and p-ERK1/2 proteins in experimental group were obviously lower than that in control (P < ...inhibiting ...
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Catalpol Protects Pre-Myelinating Oligodendrocytes against Ischemia-induced Oxidative Injury through ERK1/2 Signaling Pathway
... The vulnerability of pre-myelinating oligodendrocytes (PreOLs) to ischemic injury plays an important role in the pathogenesis and progression of perinatal white matter injury. Although oxidative stress is thought to be a ...
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Original Article microRNA-221 functions as a potential tumor promoter in colon cancer via ERK1/2 signaling pathway
... Abstract: MicroRNAs belong to a class of highly conserved small non-coding RNAs that function as posttranscrip- tional gene regulators. The aim of this study is to investigate the role of miR-221 in human colon cancer ...
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Overexpression of P16 reversed the MDR1-mediated DDP resistance in the cervical adenocarcinoma by activating the ERK1/2 signaling pathway
... of ERK1/2 in resistance to chemotherapy drugs, and that activation of the ERK protein was positively correlated with tumor cell resistance [5, ...of ERK1/2 include the transcription factors ...
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Leptin induces osteocalcin expression in ATDC5 cells through activation of the MAPK-ERK1/2 signaling pathway
... specific ERK1/2 inhibitor U0126 and a special small interfering RNA attenuated levels of leptin-induced osteocalcin expression, indicating that ERK1/2 mediates, in part, the effects of leptin ...
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Original Article EFEMP2 promotes colon cancer cell invasion and growth through the ERK1/2 signaling pathway
... Colon cancer is one of the most common malig- nant tumors in the world [1, 2]. It is a heteroge- nous disease, and diverse molecules and sig- naling pathways are involved in its development and metastasis [3]. ...
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Original Article FRS2 promotes the progression of non-small cell lung cancer
... regulate ERK1/2 signaling in other cancer ...regulated ERK1/2 signaling in ...of ERK1/2 in NSCLC cells, and we found that FRS2 knockdown led to inhibition of ...
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Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer
... MAPK signaling cascades, ERK1/2 is considered an attractive target for developing therapeutics against cancers due to its significant pharmacological specificity and selectivity ...the ...
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CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1/2-MMP2/9 pathway
... via ERK1/2 ...Smad signaling [42, 51, 57, 58], implying it might participate in extensive biological ...10 Pathway Reporter Arrays of CCL2- or CCR2-overexpressed cells showed no obvious change ...
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Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
... of ERK1/2 on hBMSCs was significantly increased after SKF-38393 treat- ment ...the ERK1/2 signaling pathway and upreg- ulated Runx2 transcriptional activity in hBMSCs, which fur- ...
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Original Article Salidroside induces apoptosis via ERK1/2 in human leukemia K562 cells
... of ERK1/2 was also ...of ERK1/2 signaling pathway in human leukemia K562 cells and may be a promising candidate for leukemia ...
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Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway
... The role of ERK MAPK in regulating cell proliferation and promoting cell survival is well defined (49 –51). Recent studies show that ERK MAPK is also activated during hypoxia in human endothelial cells (52), normal and ...
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Differential effects of ERK and p38 signaling in BMP-2 stimulated hypertrophy of cultured chick sternal chondrocytes
... ERK pathway, p38 inhibition blocked BMP-stimulated Col X promoter ...p38 signaling is important for regu- lation of Col X expression, Beier and Luvalle suggested that the proximal promoter contained a site ...
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Original Article Folic acid receptor a facilitates nasopharyngeal carcinoma via ERK1/2/NF-κB signaling pathway
... down-stream signaling protein, which activates various cytokines and cascade reactions, and ultimately leads to tumor occur- rence ...reduced ERK1/2 phosphorylation and NF-κB expression in NPC cells, ...
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Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway
... Muscular dystrophy (MD) is a destructive neuromuscu- lar disease characterized by progressive muscle weak- ness, muscle atrophy, and cardiac dysfunction [1]. In addition to the primary muscular defects, another pos- ...
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Cordyceps bassiana inhibits smooth muscle cell proliferation via the ERK1/2 MAPK signaling pathway
... signal pathway. Western blot analysis revealed increased ERK 1/2 phosphorylation in VSMCs treated with ...the ERK1/2 MAPK signaling ...
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MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway
... for 2 h at room temperature, the membranes were incubated overnight at 4 °C with the primary ...Cell Signaling Technology, USA); anti-ERK1/2 (1:500, Santa Cruz Biotechnology, USA); ...
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A Combination of Oxo-M and 4-PPBP as a potential regenerative therapeutics for tendon injury
... and ERK1/2 pathway ...selected signaling pathway may serve as focused therapeutics in comparison with delivery of stem cells, cytokines or growth ...
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Hierarchical scaffolding of an ERK1/2 activation pathway
... activated ERK1/2 from caveolae [11] argues for option (2), as it could be interpreted as handing over of activated ERK1/2 from the caveolae to the actin ...Raf signaling activity ...
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Dopamine and GABA Interaction in Basal Ganglia: GABA A or GABA B Receptor Stimulation Attenuates L DOPA Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
... (striatopallidal) pathway, subserved by D1 and D2 receptors, respectively ...indirect pathway activity occurs in PD follow- ing DA neuron degeneration in the direct pathway ...the ERK1/ ...
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