Erythroid progenitors
Angiotensin II stimulates proliferation of normal early erythroid progenitors
... After erythroid commitment of undifferentiated plu- ripotent hematopoietic stem cells, subsequent cellular divi- sions amplify the early erythroid progenitors, providing the proper quantity of cells ...
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Identification of erythroid progenitors induced by erythropoietic activity in Xenopus laevis
... Erythroid progenitors, CFU-e, reside in the liver In order to better examine the production of functional erythroid progenitors with the ability to proliferate and differentiate, we developed, ...
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Murine erythroid short term radioprotection requires a BMP4 dependent, self renewing population of stress erythroid progenitors
... for erythroid short-term radioprotection following bone marrow ...stress erythroid progenitors, which expanded in the spleen subsequent to bone marrow transplantation in ...These progenitors ...
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PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors
... Conclusions: These unexpected findings contrast with previous results in human primary cells using Epo at supraphysiological concentrations and open new doors to eventually understanding how low Epo concentrations ...
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Erythroid progenitors differentiate and mature in response to endogenous erythropoietin
... that erythroid differentiation signals may be transduced through EPOR in the absence of ...human erythroid progen- itors, it is not sufficient to transduce signals through EPOR and support cell growth, ...
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Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy
... of erythroid progenitors and blood reticulocytes and was associated with accelerated red cell recovery in myelosuppressed ...that erythroid progenitors respond to TOP and that this newly ...
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Human Parvovirus B19 Infection Causes Cell Cycle Arrest of Human Erythroid Progenitors at Late S Phase That Favors Viral DNA Replication
... B19V has a single-stranded DNA genome that is flanked by two identical terminal repeats (11). Under a single p6 promoter, the B19V genome expresses one large nonstructural protein (NS1), two small (11-kDa and 7.5-kDa) ...
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Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors
... Human parvovirus B19 (B19V) is the only human pathogenic parvovirus. It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in children and pure red cell aplasia in immunocompromised ...
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Ex Vivo-Generated CD36+ Erythroid Progenitors Are Highly Permissive to Human Parvovirus B19 Replication
... inhibited erythroid colony formation in bone marrow cultures and targeted erythroid progenitor cells (16), numerous approaches have been under- taken to culture the virus in ...
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Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
... In theory, comparison of TIS peak intensities corresponding to annotated start codons should validate the differences in ribosome density. Increased or reduced ribosome density should be mirrored by increased or reduced ...
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Inducible Gata1 suppression expands megakaryocyte erythroid progenitors from embryonic stem cells
... ferentiated into embryoid bodies, disaggregated with trypsin, and seeded into liquid culture with stem cell factor (SCF), thrombopoi- etin (TPO), and dox (Supplemental Figure 1C). Semiquantitative real-time PCR (RT-PCR) ...
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Single cell profiling of human megakaryocyte erythroid progenitors identifies distinct megakaryocyte and erythroid differentiation pathways
... tinct erythroid or megakaryocyte-specific expression with progressive separation along each ...of erythroid gene expression such as KLF1 and CNRIP1 (Additional file 1: Figure ...and erythroid ...
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Chronic myelogenous leukemia: in vitro studies of hematopoietic regulation in a patient undergoing intensive chemotherapy
... and erythroid stem cells (BFU-E) in blood did not differ from the frequencies in ...late erythroid progenitors (CFU-E) were found at a significantly lower frequency that the more primitive ...normal ...
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JAK STAT and AKT pathway coupled genes in erythroid progenitor cells through ontogeny
... stimulate erythroid differentiation, the labeled CD34 + cells of all ontogenic stages are cul- tured in the medium that contains 30% fetal bovine serum (FBS), 2 mmol/L glutamine, 100 U/ml penicillin, 100 μg/ml ...
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Recombinant Erythropoietic Growth Factors as an Alternative to Erythrocyte Transfusion for Patients With "Anemia of Prematurity"
... Rhondeau SM, Christensen RD, Ross MP, et al: Respon- siveness of marrow erythroid progenitors from infants with the “anemia of prematurity” to recombinant human eryth- ropoietin. Stockma[r] ...
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PCBP1 and NCOA4 regulate erythroid iron storage and heme biosynthesis
... during erythroid maturation, we quantitatively isolated ferritin from G1E-ER4 cells at different stages of differentia- tion via IP and measured the amounts of coprecipitated PCBP1, PCBP2, and NCOA4 (Figure ...in ...
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Stress associated erythropoiesis initiation is regulated by type 1 conventional dendritic cells
... suppression, and anemia, that result in inadequate tissue oxygenation. This stress-induced erythropoiesis is distinct from basal red blood cell generation; however, neither the cellular nor the molecular factors that ...
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5 Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin
... on erythroid precursors and progenitors was studied in nine patients with sickle cell anemia or severe ...on erythroid precursors. Late erythroid progenitors (CFU-E), present in bone ...
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Convergent extension: using collective cell migration and cell intercalation to shape embryos
... mesendoderm progenitors, notochord progenitors, which originate from cells that internalize at the shield after prechordal plate progenitors and give rise to the posterior axial mesoderm/notochord, ...
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Mechanism of Hb F stimulation by S stage compounds In vitro studies with bone marrow cells exposed to 5 azacytidine, Ara C, or hydroxyurea
... of erythroid precursors and progenitors was tested by exposing bone marrow cells to 5-aza-2'- deoxycytidine, Ara-C, or hydroxyurea in suspension cultures and reculturing the cells in drug-free clonal ...
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