Erythropoietin receptor
Phase II study of two dose schedules of C E R A (Continuous Erythropoietin Receptor Activator) in anemic patients with advanced non small cell lung cancer (NSCLC) receiving chemotherapy
... Continuous Erythropoietin Receptor Activator ...unique receptor activity and a prolonged ...from erythropoietin through the integration of amide bonds between amino groups and methoxy poly- ...
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Nanomedicines in the treatment of anemia in renal disease: focus on CERA (Continuous Erythropoietin Receptor Activator)
... (Continuous Erythropoietin Receptor Activator), has a higher molecular weight at 60 kDa and has a methoxy-polyethylene glycol chain integrated via amide bonds between the N-terminal amino group of lysine ...
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Original Article Erythropoietin and erythropoietin receptor in hepatocellular carcinoma: correlation with vasculogenic mimicry and poor prognosis
... evaluate erythropoietin (Epo) and erythropoietin receptor (EpoR) expression, its relationship with vas- culogenic mimicry (VM) and its prognostic value in human hepatocellular carcinoma (HCC), we ...
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Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55.
... The leukemogenic membrane glycoprotein gp55, encoded by Friend spleen focus-forming virus (SFFV), induces erythroid cell proliferation through its interaction with the erythropoietin receptor (EPO-R). There ...
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Cost-effectiveness of continuous erythropoietin receptor activator in anemia
... Background: Erythropoiesis-stimulating agents (ESAs) are the mainstay of anemia therapy. Continuous erythropoietin receptor activator (CERA) is a highly effective, long-acting ESA developed for once-monthly ...
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The cost-utility of treating anemia with continuous erythropoietin receptor activator or Epoetin versus routine blood transfusions among chronic hemodialysis patients
... Objective: The purpose of this study was to determine the cost-utility of treating anemic dialysis patients with continuous erythropoietin receptor activator (CERA) once mo[r] ...
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Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury
... of erythropoietin receptor (EPOR) expression in brain cells has remained difficult since previously available anti-EPOR antibodies (EPOR-AB) were ...
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Erythropoietin receptor Subunit structure and activation
... Interaction of the EPO-R with the Friend virus gp55 Since the EPO-R is a member of a large hematopoietic growth factor superfamily, any molecular insight into the EPO-R subunit structure[r] ...
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Signals for stress erythropoiesis are integrated via an erythropoietin receptor–phosphotyrosine 343–Stat5 axis
... expanded in cytokine- and dexamethasone-supple- mented SP34-EX. During expansions, CD117 (Kit) and CD71 (transferrin receptor) expression was monitored (lower panels). Morphologies of expand- ed and FACS-isolated ...
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Role of Erythropoietin Receptor Signaling in Parvovirus B19 Replication in Human Erythroid Progenitor Cells
... In this study, we show that Epo, specifically the Epo/Epo receptor (EpoR)/Janus kinase 2 (Jak2) pathway, plays a direct role in supporting replication of the B19V genome. We pre- pared CD36 ⫹ EPCs by ex vivo ...
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Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor
... Figure 4 Axonal pathology in the corpus callosum is significantly reduced by erythropoietin (EPO) after traumatic axonal injury with hypoxia (TAI + Hx). Representative photomicrographs from the corpus callosum ...
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An Array of Novel Murine Spleen Focus-Forming Viruses That Activate the Erythropoietin Receptor
... tance allele (15, 28). The surprising result that we report here is that although the BER cells infected with virus from mouse 1129 or 1218 became factor independent, and this correlated with the detection of Env ...
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Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia
... to erythropoietin (EPO), and auto- somal dominant inheritance or sporadic ...EPO receptor (EPOR) mutations were found in subjects with PFCP; most of these mutations resulted in the truncation of the ...
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Recombinant Herpes Simplex Virus Type 1 Engineered for Targeted Binding to Erythropoietin Receptor-Bearing Cells
... Full implementation of in vivo gene therapy will require directed gene delivery using targetable vectors with the appro- priate cell specificity. Viral vectors have considerable potential in this regard since the ...
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Influence of continuous erythropoietin receptor activator (CERA) administration intervals on erythropoietic effect in hemodialysis patients
... Continuous erythropoietin re- ceptor activator (CERA) has a long half-life (134 and 139 h following intravenous and subcutaneous adminis- tration, respectively) [6] and is administered at wider intervals than ...
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Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines
... the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against xenografts of female ...
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Erythropoietin does not activate erythropoietin receptor signaling or lipolytic pathways in human subcutaneous white adipose tissue in vivo
... Epo receptor mRNA was investigated, b2microglobolin were used as housekeeping ...Epo receptor PCR a RealTime ready Assay (Roche Diagnostics Corporation, 9115 Hague Road, Indianapolis, IN 46250-0414 USA) was ...
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Development of erythropoietin receptor-targeted drug delivery system against breast cancer using tamoxifen-loaded nanostructured lipid carriers
... Abstract: Tamoxifen (TAM) has been used in the treatment of breast cancers and is supplemented with erythropoietin (EPO) to alleviate the cancer-related anemia. The pur- ported deleterious effects caused by the ...
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Expression of the erythropoietin receptor by germline-derived cells - further support for a potential developmental link between the germline and hematopoiesis
... of erythropoietin (0 – 100 U/ml) on adhesion of P19 cells to ...of erythropoietin (0 – 100 U/ml) on the chemoattraction of P19 cells across Transwell membranes covered with ...of erythropoietin (0 – ...
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Erythropoiesis: insights into pathophysiology and treatments in 2017
... EPO: Erythropoietin; EPO-R: Erythropoietin receptor; ERFE: Erythroferrone; GvHD: Graft-versus-host disease; HAMP: Hepcidin antimicrobial peptide; HbE β 0: Hemoglobin E/ β -thalassemia; HbH: ...
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