estrogen receptor α
LXRβ/estrogen receptor α signaling in lipid rafts preserves endothelial integrity
... Liver X receptors (LXR) are stimulated by cholesterol-derived oxysterols and serve as transcription factors to regulate gene expression in response to alterations in cholesterol. In the present study, we investigated the ...
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Expression patterns of STAT3, ERK and estrogen-receptor α are associated with development and histologic severity of hepatic steatosis: a retrospective study
... and α -smooth muscle actin (cytoplasm, red color) in hepatic stellate cells ...and α -smooth muscle actin (cytoplasm, red color) in hepatic stellate cells ...of estrogen-receptor α in ...
9
Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling
... of estrogen receptor-α (ERα) in Ishikawa and ARK1 endometrial cancer cells ...the estrogen regulation of NPM1 expression in primary-cultured International Federation of Gynecology and ...
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miRNAs involved in LY6K and estrogen receptor α contribute to tamoxifen-susceptibility in breast cancer
... receptors: estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) ...on estrogen receptor α (ERα) [2], so diverse treatment ...
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Src promotes estrogen dependent estrogen receptor α proteolysis in human breast cancer
... Estrogen drives both transcriptional activation and proteolysis of estrogen receptor α (ERα; encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 ERα-negative ...
12
Estrogen receptor α signaling in osteoblast progenitors stimulates cortical bone accrual
... of estrogen receptor-α (ERα) in osteoblasts and osteoclasts over 20 years ago suggested that direct effects of estrogens on both of these cell types are responsible for their beneficial effects on ...
12
Membrane estrogen receptor α levels predict estrogen induced ERK1/2 activation in MCF 7 cells
... [40,41]. Our MCF-7 cells expressed both caveolin-1 and - 2, and ER-α was associated with the same gradient frac- tions in which most of the caveolin proteins were detected. A 67 kDa ER and a variant of lower ...
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MEL 18 loss mediates estrogen receptor–α downregulation and hormone independence
... We here provide the first evidence to our knowledge for the SUMOylation-related transcriptional regulation of ESR1 by MEL-18. Although the effects of SUMOylation on p53 transcriptional activity are controversial, our ...
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Estrogen receptor α gene haplotype is associated with primary knee osteoarthritis in Korean population
... Several variations in the DNA sequence of the ER-α gene have been reported [11,12]. A few reports have examined the association between ER-α gene polymorphisms and OA; the findings are controversial. ...
7
Estrogen receptor–α in medial amygdala neurons regulates body weight
... Since energy expenditure is contributed by 3 components — physical activities, resting metabolic rate, and thermogenesis (22) — we further dissected these 3 components in female SIM1-ERα-KO mice. Remarkably, physical ...
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Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF 1 and AF 2 and estrogen receptor β transcriptional activity
... Immunocytochemical analysis of the effects of prenyltransferase inhibitors on estrogen receptor (ER) α distribution in MCF-7 cells. (a) Cells, deprived of estradiol (E2) for 7 days, were treated or ...
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Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor β
... ERA-63 inhibits the tetanus toxoid (TT)-specific DTH response in WT and ERβ-/- mice but not in ERα-/- mice To further substantiate our findings on ERα-mediated immune suppression, we evaluated ERA-63 on suppres- sion of ...
12
Association of estrogen receptor α and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment
... Nuclear extracts from progestin-treated or virgin control mice were used for Western blots (Figure 5a). Extracts were nor- malized by protein content. Because mammary glands from vir- gin mice have less epithelial cells ...
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Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1
... Estrogen exposure has been regarded as high risk factor of breast cancer. It has been reported that HBO1 strongly enhanced ER-mediated transcription [9], which indicated that HBO1 might play a role in the progress ...
7
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical
... In the context of these challenges, we applied two strategies to robustly and accurately monitor the process of nuclear receptor binding to chromatin on activation. The first strategy was to increase the number of ...
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Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
... hormone estrogen classically exerts its effects by mod- ifying gene expression ...of estrogen and other related steroid hormones in a variety of tissues includ- ing the vasculature, brain, and bone ...of ...
7
Molecular Docking, 3D Structure-Based Pharmacophore Modeling, and ADME Prediction of Alpha Mangostin and Its Derivatives against Estrogen Receptor Alpha
... with estrogen receptor α (ERα) were analyzed using molecular docking simu- lation and showed the overall binding energy of α-mangostin derivatives have better affinity to ERα compared to its ...
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Selective activation of miRNAs of the primate-specific chromosome 19 miRNA cluster (C19MC) in cancer and stem cells and possible contribution to regulation of apoptosis
... C19MC: The human chromosomal 19 miRNA cluster; ER α : Estrogen receptor α ; ESC: Embryonic stem cells; GO: Gene ontology; HCT15 and SKCO1: Colorectal cancer; HepG2: Liver cancer; HWP: Hu[r] ...
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LACTATIONAL EXPOSURE TO DI-2-ETHYL HEXYL PHTHALATE (DEHP) INDUCES OXIDATIVE STRESS AND CAUSES NEURODEGENERATION IN HIPPOCAMPUS OF OFFSPRING FEMALE ALBINO RATS
... (ATP) content [13]. ATPases are lipid dependent membrane bound enzymes. Any perturbation in the activities of ATPases affects the membrane status by inflicting changes in the electrophysiological energetic and the normal ...
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Metabolic properties of the osteoclast
... osteoclasts and their mononuclear progenitor cells [65,32]. Knockdown of HIF-1α is reported to abolish resorption pit formation in normoxic cultures of osteoclast-forming mouse marrow cells [24]. HIF-1α knockdown has ...
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