Estrogen receptor α gene
Estrogen receptor α gene haplotype is associated with primary knee osteoarthritis in Korean population
... human estrogen receptor (ER) has two isoforms: ER-α and ...ER-α gene is greater than 140 kilobases, contains eight exons, and is located on chromosome 6q25 ...
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The Transactivating Function 2 (AF 2) of Estrogen Receptor (ER) α Is Indispensable for ERα Mediated Physiological Responses and AF 1 Activity
... active or inactive form of the receptor. When agonists (transcription activating chemicals) bind to the LBD, helix 12 makes a co-activator binding surface and re- cruits transcriptional co-activators, such as ...
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Estrogen receptor–α in medial amygdala neurons regulates body weight
... the gene encoding ERα (Esr1) from SIM1 neurons, which are mostly within the MeA, caused hypoactivity and obesity in both male and female mice fed with regular chow, increased susceptibility to diet-induced obesity ...
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Proximal and distal regulation of the HYAL1 gene cluster by the estrogen receptor α in breast cancer cells
... hormone-dependent gene activation by ERα, but relatively little is known about how estrogen represses gene ...that estrogen repression of HYAL1 involves direct binding of ERα to the ERE-900 ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... its gene [7]. We cannot rule out that this inactivation of ER-α could also be due to a negative regulation by BORIS, since a deregulation of the ER-α receptor in patients with endometrial ...
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Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
... hormone estrogen classically exerts its effects by mod- ifying gene expression ...of estrogen and other related steroid hormones in a variety of tissues includ- ing the vasculature, brain, and bone ...
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Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy
... for estrogen receptor alpha positive (ER α +) breast ...ER α + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor ...the Gene Expression ...
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Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation
... its receptor Rxfp1 and key genes chosen to represent angiogenesis (total VEGFA (VegfA), VEGF receptor 2 (Vegfr2)), steroid re- ceptors (estrogen receptor (ER)-α (Esr1), ER-β (Esr2), ...
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LACTATIONAL EXPOSURE TO DI-2-ETHYL HEXYL PHTHALATE (DEHP) INDUCES OXIDATIVE STRESS AND CAUSES NEURODEGENERATION IN HIPPOCAMPUS OF OFFSPRING FEMALE ALBINO RATS
... ER α and β were also included in the network (Figure ...analysis. Gene ontology (GO) annotations indicated that these proteins were enriched for molecular functions such as ‘ligand-dependent nuclear ...
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Membrane estrogen receptor α levels predict estrogen induced ERK1/2 activation in MCF 7 cells
... of estrogen at the transcriptional ...to estrogen response elements, but that the resultant transcriptional unit is inactive ...in gene transcrip- ...between estrogen or antiestrogen ...
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Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma
... Orai3 channel has emerged as important player in malignant transformation. Indeed, its expression is increased in cancer and favors cell proliferation and survival by permitting calcium influx. In this study, Orai3 was ...
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Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
... coupled estrogen receptor (GPER) has been involved in the stimulatory action of estrogens in breast ...the gene encoding FAK, namely PTK2, is higher in TNBC respect to non-TNBC and normal breast ...
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Clinicopathological Correlation of Estrogen Receptor Alpha Gene Polymorphism and Estrogen Receptor Status in Breast Cancer - A Study.
... OF ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISM AND ESTROGEN RECEPTOR STATUS IN BREAST CANCER- A STUDY OF 153 CASES” is the original and bonafide work done by ...
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The association of inherited variation in the CLOCK gene with breast cancer tumor grade
... There were technical problems that diminished the results from the study. From a total of 496 patients, 55 patients had a SNP call rate of less than 90%, and two SNPs exhibited a poor genotyping performance. An ...
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Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... Tamoxifen resistance has also been shown to emerge from a subpopulation in which epidermal growth factor receptor (EGFR) and/or Her2 mitogenic signaling is hyperactived. Transfection and activation of these ...
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Immunohistochemical Evaluation of Ovarian Hormonal Receptors in Canine Mammary Tumors
... receptors, estrogen receptor α (ERα) and β (ERβ), progesteron receptor (PR) and andro- gen receptor (AR) ...of estrogen receptor α (ERα) and β (ERβ), progesterone ...
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Chromatin immunoprecipitation assay detects er recruitment to gene specific promoters in uterus
... (2). Estrogen primarily controls gene transcription via interaction with two nuclear receptors ERα (Esr1) and ERα (Esr2) that belong to a family of ligand-activated transcription factors ...biology, ...
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Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells
... Fc receptor blocking with anti-CD16/CD32 (Biolegend, USA), cells were incubated with anti-CD45-Pacific Blue, anti-F4/ 80-PE, anti-Ly-6C-FITC, anti-CD11b-PE, anti-CD3ε-APC, anti-CD4-FITC, anti-IFN-γ-PE, ...
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Original Article Association of estrogen receptor alpha gene polymorphisms and its gene-gene interactions with knee osteoarthritis susceptibility in Chinese Han population
... ESR1 gene on knee OA risk by using GMDR ...potential gene-gene interaction between rs22- 28480 and rs9340799 on knee OA risk, Ov- erall, the cross-validation consistency of this two-locus model was ...
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Metabolic properties of the osteoclast
... osteoclasts and their mononuclear progenitor cells [65,32]. Knockdown of HIF-1α is reported to abolish resorption pit formation in normoxic cultures of osteoclast-forming mouse marrow cells [24]. HIF-1α knockdown has ...
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