Estrogen receptor α/β
Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus
... i.e., estrogen receptor (ER)α and ERβ, which function as ligand-activated nuclear transcription factors producing genomic effects ...[7]. Estrogen receptors are expressed in different cell ...
10
LACTATIONAL EXPOSURE TO DI-2-ETHYL HEXYL PHTHALATE (DEHP) INDUCES OXIDATIVE STRESS AND CAUSES NEURODEGENERATION IN HIPPOCAMPUS OF OFFSPRING FEMALE ALBINO RATS
... (ATP) content [13]. ATPases are lipid dependent membrane bound enzymes. Any perturbation in the activities of ATPases affects the membrane status by inflicting changes in the electrophysiological energetic and the normal ...
12
Changes in the expression of aromatase, estrogen receptor α and β in mandibular condylar cartilage of rats induced by disordered occlusion
... that estrogen can be synthesized through estrogen synthetase - aromatase not only by gonadal glands but also by a number of extrago- nadal sites including mandibular condylar cartilage, in which ...
9
Naringenin modulates skeletal muscle differentiation via estrogen receptor α and β signal pathway regulation
... Several studies indicate that E2 deficiency inhibits the muscle regeneration, and E2 supplementation enhances muscle mass and strength (Wust et al. 2008) accelerating skeletal muscles regeneration (McClung et al. 2006; ...
13
Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF 1 and AF 2 and estrogen receptor β transcriptional activity
... the estrogen signaling pathway has proved to be of great value in the treatment of human breast cancer, and current evidence suggests that such targets hold great potential in the prevention of human breast ...the ...
11
Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor β
... Differential effects of ERα and ERβ ligands in EAE have been described [46,47]. Moreover, clinical trials with oestrogens in multiple sclerosis have been described showing immune modulatory effects [48,49]. Clinical tri- ...
12
Immunohistochemical Evaluation of Ovarian Hormonal Receptors in Canine Mammary Tumors
... receptors, estrogen receptor α (ERα) and β (ERβ), progesteron receptor (PR) and andro- gen receptor (AR) ...of estrogen receptor α (ERα) and β (ERβ), ...
7
Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen
... for β-galactosidase revealed success- ful expression of the protein in 15%–20% of cells, and immunos- taining for ERα confirmed enhanced expression in 20%–40% of cells transfected with ERα ...on ...
7
Src promotes estrogen dependent estrogen receptor α proteolysis in human breast cancer
... ER α and β -actin were assayed 6 hours later. (D) Serum- and estrogen-deprived MCF-7 cells were transferred to 5% FBS plus estradiol with or without added Src inhibitor PP1, and ERα was assayed 6 ...
12
Estradiol’s Salutary Effects on Keratinocytes Following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)-α and ER-β
... ceived estrogen (50 μg/kg BW), or an equal volume and concentration of vehi- cle (cyclodextrin), PPT (5 μg/kg BW), DPN (5 μg/kg BW), and/or ICI 182,780 (ICI; 150 μg/kg BW) subcutaneously at the middle of ...
8
Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... We identified a strong nuclear expression of ER-α in the cervical squamous epithelium, but not in the HSIL or SC, coinciding with previous reports [6, 7, 32-34], except for some cases of CC with ER-α ...
14
DAX 1 expression in human breast cancer: comparison with estrogen receptors ER α, ER β and androgen receptor status
... For Western blot analysis, tissues were homogenized in extraction buffer (10 mM Tris-HCl, pH 7.6, 10 mM KCl, 1 mM 1,4-dithiothreitol, and 0.2 M EDTA, pH 8) in addition to a cocktail of protease inhibitors (1 mM ...
9
Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation
... its receptor Rxfp1 and key genes chosen to represent angiogenesis (total VEGFA (VegfA), VEGF receptor 2 (Vegfr2)), steroid re- ceptors (estrogen receptor (ER)-α (Esr1), ER-β ...
14
The Expression of Estrogen Receptors in Hepatocellular Carcinoma in Korean Patients
... of estrogen receptors (ER)- and - , as well α β as androgen receptor (AR), in hepatocellular carcinoma (HCC) is thought to be correlated with prognosis, survival, and male prevalence of ...
6
Estrogen receptor β protects against acoustic trauma in mice
... hydroxyphenyl)-propionitrile (DPN), protected WT and ARKO mice. Immunohistochemistry and western blotting confirmed the expression of ERb in cochlea of WT males and females. Levels of brain-derived neurotrophic factor ...
9
Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala
... that estrogen, especially ethi- nyl estradiol (EE) from COC (combined oral contracep- tives), may play a role in ASD development [8], although current literatures have not reached a conclusion ...
16
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical
... the Estrogen Receptor- a (ER) has played a fundamental role in both our understanding of transcription factors and cancer ...ER: Estrogen Response Elements; EREs). On the chromatin, the nuclear ...
13
Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... are a mathematical coincidence, or an artifact of the data. If, however, the proposed hypothesis were true, the clinical impli- cation is that while most women at high risk benefit from tamoxifen prophylaxis, there is a ...
6
Estrogen receptor–α in medial amygdala neurons regulates body weight
... resemble mice lacking ERα in SIM1 neurons or in the MeA. It is worth noting that the MeA expresses abundant aromatase (33), which makes it possible that ERα in male MeA could be exposed to high levels of 17β-estradiol ...
17
Membrane estrogen receptor α levels predict estrogen induced ERK1/2 activation in MCF 7 cells
... can speculate that the observed effect of ICI182,780 was genuine and resulted from potentially increased levels of mER in long-term estrogen deprived MCF-7 cells, because our previous studies suggested that serum ...
15