Estrogen Receptor alpha
Clinicopathological Correlation of Estrogen Receptor Alpha Gene Polymorphism and Estrogen Receptor Status in Breast Cancer - A Study.
... OF ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISM AND ESTROGEN RECEPTOR IN BREAST CANCER- A STUDY OF 153 CASES ” is the original and bonafide work done by me under the guidance of ...
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Original Article Association of estrogen receptor alpha gene polymorphisms and its gene-gene interactions with knee osteoarthritis susceptibility in Chinese Han population
... Abstract: Aims: To investigate the association of estrogen receptor alpha (ESR1) gene polymorphisms and its gene-gene interactions with knee osteoarthritis (OA) susceptibility. Methods: Generalized ...
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Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint
... of estrogen in the human female, having biological effects through binding the estrogen receptor alpha (ERα) and beta (ERβ) ...the estrogen receptors ERα and ERβ in the thymus [14,15], ...
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Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization
... and estrogen signaling, and that Memo controls Estrogen Receptor alpha (ERα) sub-cellular localization, phosphorylation, and function downstream of heregulin and estrogen in breast ...
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Original Article Estrogen receptor alpha gene polymorphisms contribute to fragility fracture susceptibility in elderly postmenopausal women with heart failure
... Abstract: Objective: The association between estrogen receptor alpha (ESR1) gene PvuII polymorphism and frac- ture risk is still ambiguous and inconclusive. Furthermore, this relationship in ...
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A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance
... Previous studies indicate that BRCA1 protein binds to estrogen receptor-alpha (ER) and inhibits its activity. Here, we found that BRCA1 over-expression not only inhibits ER activity in ...
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Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo
... of estrogen in the regulation of neoplastic cartilage growth in a larger cohort of various chondrosarcoma subtypes, including conventional central and peripheral chondrosarcoma as well as dedifferentiated, ...
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Role of Estrogen Receptor-Alpha in an Experimental Model of Bronchial Asthma
... Further, 30-40% of women who have asthma have experienced worsening of their symptoms during the premenstrual phase, when estrogen and progesterone concentrations are changing rapidly [26]. Moreover, a recent ...
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pRb controls Estrogen Receptor alpha protein stability and activity
... Our data here show that the pRb protein plays an important role as an adaptor in the regulation of ESR1 stability and functionality, a key player in hormonal therapy. The N-terminal domain of pRb interacts with the ESR1 ...
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Cohesin is required for expression of the estrogen receptor-alpha ( ESR1 ) gene
... the estrogen-induced expression of ER α target ...the estrogen-regulated genes CXCL12, GREB1, PGR, and PKIB were normalized to 28S ribosomal mRNA, graphed relative to the control sample and expressed as ...
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Molecular Docking, 3D Structure-Based Pharmacophore Modeling, and ADME Prediction of Alpha Mangostin and Its Derivatives against Estrogen Receptor Alpha
... docking simulation were clustered using a root mean square deviation (RMSD) tolerance of 1.0 Å. The ligand conformation with the lowest free binding energy (∆G) was chosen from the most favored cluster. The best ligand ...
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Targeting estrogen/estrogen receptor alpha enhances Bacillus Calmette-Guérin efficacy in bladder cancer
... integrin-α5β1 receptor complex and that this complex is up-regulated by the cytokine IL-6 ...by estrogen, which has been shown to reverse this effect ...
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The role of total and cartilage specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis
... long-term estrogen treatment to postmenopausal women is associated with severe side effects, knowledge about the mechanism behind the protective effects of estrogen is of considerable importance in the ...
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The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells
... ER α activation was unable to induce the drug resistance of natural ER α positive T47D breast cancer cells. Although it increased the drug resistance of Bcap37 cells transformed from ER α -negative breast cancer cells, ...
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Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-α for infantile hemangioma
... their receptor have direct effect on IHs, we investigated the effect of E2 in apoptosis, growth and expression of angiogenic factors of hemangioma-derived stem cells (HemSCs) using both in vitro and in vivo ...
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The origins of estrogen receptor alpha positive and estrogen receptor alpha negative human breast cancer
... by estrogen-induced paracrine factors from adjacent ER-positive cells, which can become independent of this support, achieve a growth advantage, and progress to ER-negative breast ...for receptor-negative ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... important determinant of the agonist/antagonist activity of SERMs. There is already evidence that the level of N-CoR is correlated with tamoxifen sensitivity or resistance [54 •• ], and L7/SPA is recruited by the ...
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Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer
... of estrogen receptors (ER) in prostate suggests that estrogens may act directly in prostate epithelial cells ...for estrogen receptors will further elucidate our understanding of their roles in prostate ...
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Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer
... of estrogen receptor alpha in complex with DeS and a GRiP1 peptide, and of estrogen-related receptor alpha in complex with a PGC-1α peptide, are shown ...
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Chromatin immunoprecipitation assay detects er recruitment to gene specific promoters in uterus
... examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERα), a ligand-activated transcription factor, to uterine gene promoters in ...that ...
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