Estrogen Signaling
Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation
... of estrogen on the accumulation of genetic instabilities upon loss of BRCA1, and assessed the contribution of estrogen signaling to the incidence and progression of Brca1-mutated mammary ...with ...
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Modulation of estrogen signaling in hepatic and vascular tissue
... by estrogen in liver of wt mice [14,15], and a decrease of estrogen signaling would thus be in line with SHP ...in estrogen signaling in such a manner as to maintain normal plasma and ...
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Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers
... and estrogen signaling in predicting recurrence may explain why biomarkers that do not take into account such information (PAM50, Oncotype DX) do not predict late recurrences well ...
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Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo
... In addition, in spite of positive immunohistochemical staining for ESR1 protein in all in vitro cell cultures, addi- tion of 17 b -estradiol, 4-androstene-3,17-dione or drugs targeting the ...
9
Dual roles for Id4 in the regulation of estrogen signaling in the mammary gland and ovary
... for estrogen biosynthesis in the ovary was decreased in Id4-deficient females and uterine weights were considerably lower, indicating impaired estrogen ...circulating estrogen likely contribute to ...
6
Arsenic abrogates the estrogen-signaling pathway in the rat uterus
... of estrogen receptor (ER alpha), the estrogen-responsive gene - vascular endothelial growth factor (VEGF), and G1 cell cycle proteins, cyclin D1 and CDK4, was also ...the estrogen signaling ...
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Metastasis-associated protein 1 (MTA1) is transferred by exosomes and contributes to the regulation of hypoxia and estrogen signaling in breast cancer cells
... enhance estrogen receptor signaling, and sensitize them to tamoxifen treatment ...the estrogen signaling response was attenuated in both MCF7 wildtype and MTA1-knockout cells ...effects ...
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Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2
... implicate estrogen receptor (ER)-mediated genomic and nongenomic sig- naling as well as the action of genotoxic estrogen meta- bolites ...of estrogen signaling in advanced disease may inform ...
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Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implications
... with estrogen receptor (ER)+ tumors, suggesting that the etio- logic factors, clinical characteristics, and therapeutic possibilities may vary by molecular ...proper estrogen signaling seems to be a ...
18
Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization
... RTK signaling Memo may have an important role in estrogen ...E2 signaling in breast cancer, and is an important new player in the crosstalk between the two ...
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Estrogens Impair Antitumor Immunity By Promoting The Accumulation Of Myeloid-Derived Suppressor Cells
... in estrogen-dependent, receptor (ER) positive breast cancer; however, little is known about their potential role in cancers that are not thought to be estrogen-dependent, such as ovarian ...of ...
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Original Article Transcriptomic analysis of dracorhodin perchlorate intervention in wound healing in SD rats
... dgehog signaling pathway, malaria, and basal cell ...the estrogen signaling path- way, Hippo signaling pathway, and Cushing syn- drome, whereas downregulated genes were enriched in the ...
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Estrogen regulates Hippo signaling via GPER in breast cancer
... of estrogen signaling (either by blocking estro- gen production or inhibiting ER function) is a common clinical approach to treat ER-positive breast ...
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SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells
... alpha signaling in breast ...beta signaling and P53 signaling [24, ...supporting estrogen signaling and breast cancer progres- ...
12
Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells
... E2 signaling for cell growth, potentially requiring higher dose of E2 to achieve optimal growth sig- ...of estrogen for growth comparable to pMIG ...for estrogen in pMIG cells was 15 pM while it was ...
11
Dangguijakyak san ameliorates memory deficits in ovariectomized mice by upregulating hippocampal estrogen synthesis
... Astrocytes, which are the most abundant glial cells in the mammalian brain, involve in the metabolic control of estrogen and has the potential to mediate neuropro- tective actions of estrogen [50–52]. Thus, ...
8
Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer
... with estrogen resembling the EMT process (Figure ...upon estrogen treatment (Figure ...with estrogen, and an upregulation in Vimentin mRNA level, which is a mesenchymal marker (Figure ...that ...
15
The roles of androgen, estrogen, and retinoid signaling in reproductive recrudescence of the eastern mud snail (Ilyanassa obsoleta): Implications for the mechanism of tributyltin-induced imposex
... the signaling pathways and associated functions of vertebrate-like sex steroids in molluscan reproductive endocrinology is of particular interest because molluscs exposed to endocrine disrupting chemicals (EDCs) ...
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Estrogen modulates mesenchyme epidermis interactions in the adult nipple
... nipple-specific signaling factors, we compared gene expression signatures of sorted Pdgfr α -positive ventral K14-PTHrP and wild-type fibroblasts, identifying differentially expressed transcripts that are involved ...
12
Differential expression of breast cancer associated genes between stage and age matched tumor specimens from African and Caucasian American Women diagnosed with breast cancer
... in estrogen signaling, including AR, BCL2, CCND1, ESR1, GATA3, IGFBP2, IL6ST, KRT19, MUC1, PGR, SERPINE1, HSPB1, SERPINA3, and STC2, all of which displayed decreased expression in AAW compared to CAW ...
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