ethacrynic acid
Effects of Ethacrynic Acid on the Isolated Collecting Tubule
... The base-line water permeability of the collecting tubule was not affected when the drug (10 −4 M) alone was added to the bathing medium. Vasopressin alone in the bathing medium (2, 5 µU/ml) elicited a significant ...
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Fluid secretion by the malpighian tubules of the tsetse fly Glossina morsitans: the effects of ouabain, ethacrynic acid and amiloride
... As we have seen, the secretion of fluid by the Malpighian tubules of Glossina is inhibited by ethacrynic acid, and since this compound causes the complete inhibition of fluid secretion, [r] ...
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High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid
... Aberrant activation of lymphoid enhancer-binding factor-1 (LEF1) has been identified in several cancers, including chronic lymphocytic leukemia (CLL). As a key transcription factor of the Wnt/β-catenin pathway, LEF1 ...
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Furosemide versus ethacrynic acid in pediatric patients undergoing cardiac surgery: a randomized controlled trial
... Enrolled patients were randomized to receive either 0.2 mg/kg/h of furosemide or an equivalent dose of ethacrynic acid in a double-blind fashion. The attending physicians were allowed to increase the drugs ...
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THE USE OF ETHACRYNIC ACID IN INFANTS AND CHILDREN WITH CONGESTIVE HEART FAILURE
... Administration of intravenous ethacrynic acid to eight study patients ( ages 2 months to 17 years ) with congestive heart failure was followed by an average weight loss of 3.6% (range 0.[r] ...
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Reversal of Cyclic AMP Mediated Intestinal Secretion by Ethacrynic Acid
... Ethacrynic acid (EA) has been reported to reduce cholera toxin-induced intestinal fluid secretion in the intact animal. We explored the nature of this inhibition in vitro by measuring unidirectional, ...
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Renal Tubular Effects of Ethacrynic Acid
... The effects of ethacrynic acid on urinary dilution CH2O.- When ethacrynic acid was administered at the height of water diuresis, there was an immediate increase in urine flow and solute [r] ...
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THE USE AND MODE OF ACTION OF ETHACRYNIC ACID IN NEPHROGENIC DIABETES INSIPIDUS
... Effect of Long-Term Use of Oral Ethacrynic Acid on Clearance of Free Water.. While receiving a 60 mEq sodium diet,.[r] ...
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Ethacrynic Acid EFFECTS ON THE COCHLEAR POTENTIALS IN NORMAL AND HIGH BLOOD OXYGEN
... Experimental data seem to indicate that elevation of the Po2 to 174-179 mm Hg during relatively high doses of EA treatment prevents the declines in cochlear potentials which were observe[r] ...
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Effects of Ethacrynic Acid (a New Saluretic Agent) on Renal Diluting and Concentrating Mechanisms: Evidence for Site of Action in the Loop of Henle
... Solute i.e., sodium chloride reabsorption in the loop is greater than water reabsorption, corresponding to approximately 14 to 21%o of filtered sodium.2 A drug that would completely inhi[r] ...
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Investigation of brain tumors using <sup>18</sup>F-fluorobutyl ethacrynic amide and its metabolite with positron emission tomography
... Inhibitors at various concentrations were assessed for their ability to compete with chlorodinitrobenzene (CDNB) for GST-catalyzed conjugation to GSH using a GST assay kit (Cayman Chemical, Ann Arbor, MI, USA) according ...
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100 years of sickle cell disease research: etiology, pathophysiology and rational drug design (part 1)
... In a trial to overcome the poor oral bioavailability of aldehydes, a series of imidazolylacryloyl derivatives were designed using ethacrynic acid (ECA); 2-(2,3-dichloro-4-(2- ...
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Ouabain Uninhibited Sodium Transport in Human Erythrocytes EVIDENCE AGAINST A SECOND PUMP
... Others have concluded that a second Na “pump” (active Na outflux) exists in human erythrocytes. This second pump was said to be ouabain-insensitive, unlike the classic ouabain-sensitive Na-K pump. An alternative ...
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Diuretics stimulate H+ secretion in turtle urinary bladder
... The effect of various diuretics on H+ secretion was studied in the isolated short-circuited urinary bladder of the turtle. Mucosal (urinary) chlorothiazide stimulated H+ secretion promptly, from 1.33 +/- 0.24 to 3.03 +/- ...
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A study of sodium transport in kidney and intestine and its sensitivity to angiotensin
... The effect of adding ethacrynic acid in the absence of potassium or in the presence of ouabain on sodium extrusion and potassium uptake by kidney cortex slices The effect of ethacrynic a[r] ...
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Abnormal membrane sodium transport in Liddle's syndrome
... ouabain, ethacrynic acid, and to changes in the cation composition of the incubation medium suggests that the increased sodium fluxes in Liddle's syndrome do not result solely from a quantitative increase ...
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Uphill Transport of Urea in the Dog Kidney: Effects of Certain Inhibitors
... To study the renal medullary transport and accumulation of urea in dogs independent of water transport, we obliterated the medullary electrolyte gradient by a sustained ethacrynic acid d[r] ...
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Comparison of the anticonvulsant potency of various diuretic drugs in the maximal electroshock-induced seizure threshold test in mice
... amiloride, ethacrynic acid, hydrochlorothiazide, and in- dapamide) in the maximal electroshock-induced seizure threshold (MEST) test in mice in order to assess their an- ticonvulsant potency in this seizure ...
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Concentration dependence of active potassium transport in the human red blood cell in the presence of inhibitors
... The active potassium influx in the human red blood cell is inhibited by strophanthidin, ethacrynic acid, and MK-870 a new diuretic, and the degree of inhibition is greater at low concent[r] ...
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Investigation on Fatty Acid Composition of Oil Extracted from Carica papayaL. Seed
... Both leaf and fruit of the Carica papaya L. possess carotenoids namely β-carotene, lycopene, anthraquinones glycoside, as compared to matured leaves and hence possess medicinal properties like anti-inflammatory ...
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