Ethyl pyruvate
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
... Adult male BALB/c mice (22-25 g) were allowed to accli- matize for one week housed at 25°C on a 12-h light/12-h dark cycle; all animals were allowed free access to water and standard laboratory chow. All studies were ...
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Bench to bedside review: Amelioration of acute renal impairment using ethyl pyruvate
... Ethyl pyruvate decreases sepsis-induced acute renal failure in ...intraperitoneal ethyl pyruvate immediately after surgery partially inhibited muscle, liver and pancreatic ...Furthermore, ...
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Original Article Ethyl pyruvate reduces hepatic mitochondrial swelling and dysfunction in a rat model of sepsis
... Abstract: Sepsis causes mitochondrial oxidative injury and swelling. Ethyl pyruvate (EP) is a cytoprotective agent, while aquaporin-8 (AQP8) is a mitochondrial water channel that can induce mitochondrial ...
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Ethyl Pyruvate Has Anti Inflammatory and Delayed Myocardial Protective Effects after Regional Ischemia/Reperfusion Injury
... Purpose: Ethyl pyruvate has anti-inflammatory properties and protects organs from ischemia/reperfusion (I/R)-induced tissue ...whether ethyl pyruvate decreases the inflammatory response after ...
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Protective effect of ethyl pyruvate on mice sperm parameters in phenylhydrazine induced hemolytic anemia
... The aim of the present study was to assess the protective effect of ethyl pyruvate (EP) on sperm quality parameters, testosterone level and malondialdehyde (MDA) in phenylhydrazine (PHZ) treated mice. For ...
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Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
... Ethyl pyruvate (EP) is a simple derivative of pyruvic acid, which is an important endogenous metabolite that can scavenge reactive oxygen species ...
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Protective Effect of Ethyl Pyruvate on Epididymal Sperm Characteristics, Oxidative Stress and Testosterone Level in Methotrexate Treated Mice
... In table 2, we can see that regarding sperm mo- tility, compared with the control group, RPFM decreased significantly (p<0.05) in methotrexate group. However, Ethyl pyruvate caused an in- crease in RPFM ...
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Inhibitory Effect of Ethyl Pyruvate on Orthotopic Transplantation of Gastric Cancer in Severe Combined Immunodeficiency Mice
... of ethyl pyruvate (EP) on the growth and liver metastasis of orthotopically transplanted gastric cancer in severe combined immunodeficiency (SCID) ...
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Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity
... obtained from Invivogen (San Diego, California). Ethyl pyruvate (EP) was purchased from ThermoFisher Scientific(Shanghai, China). Anti-mouse IL-1β (AF-401- NA) was from R&D and anti-mouse caspase-1 ...
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Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury
... whereas pyruvate is a glycolysis product and substrate for TCA ...of pyruvate is limited. Ethyl pyruvate (EP) is now considered as a suitable replacement of ...
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Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose
... Results: Twenty-four hours after APAP challenge, compared to the saline-treated group, EP treatment significantly lowered serum transaminases ALT/AST and reduced liver injury seen in his[r] ...
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Ethyl pyruvate protects against sepsis by regulating energy metabolism
... Of the effects of EP, its antioxidative effect has the most potential. We detected the TAC and MDA levels in liver homogenates. As shown in Figure 3, compared with those in the Sham group, the TAC (Figure 3A) levels were ...
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Ethyl Pyruvate Inhibits HMGB1 Phosphorylation and Release by Chelating Calcium
... sodium pyruvate into the solution con- taining mag-fura-2 and CaCl 2 , the band at 330 nm decreased but the band at 370 nm corresponding to free mag-fura-2 did not increase (Figure 2D), which sug- gested that ...
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Intratracheal instillation of ethyl pyruvate nanoparticles prevents the development of shunt-flow-induced pulmonary arterial hypertension in a rat model
... MDA assay showed that the EP-NP treatment obviously prevented the increased MDA induced by shunt flow compared with the blank, vehicle, and EP-only groups (P , 0.05, Figure 6D).. Thes[r] ...
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Ethyl pyruvate reduces organic dust-induced airway inflammation by targeting HMGB1-RAGE signaling
... Hence, we tested a hypothesis that organic dust exposure of airway epithelial cells induces nucleocytoplasmic translocation of HMGB1 and blocking this translocation dampens organic dust-[r] ...
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Complete genome sequence of Desulfobulbus propionicus type strain (1pr3T)
... methylmalonyl-CoA: pyruvate tran- scarboxylase, a key enzyme of methylmalonyl-CoA pathway, as well as the other enzymes (pyruvate dehydrogenase, succinate dehydrogenase and ma- late dehydrogenase) involved ...
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Efficient production and secretion of oxaloacetate from Halomonas sp. KM-1 under aerobic conditions
... Oxaloacetate is an important intermediate chemical in the TCA cycle, glycogenesis, and aspartic acid biosynthe- sis. It is used as a health food based on its role in energy synthesis; however, it can easily be ...
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Increased isobutanol production in Saccharomyces cerevisiae by eliminating competing pathways and resolving cofactor imbalance
... alcohol dehydrogenase genes has recently been con- structed [30], this strategy is unlikely to be effective be- cause the Ehrlich pathway for isobutanol biosynthesis also requires an alcohol dehydrogenase gene (ADH6). ...
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Aldehydes, Acids and Esters Analysis of Brandy Aged in Oak Barrels Treated by Electric Field
... processes of wines. Studies [17] indicated that when freshly fermented model wines were treated by PEF, colour intensity and total phenols in the wines could be enhanced. Also Liu et al. showed decrease in relative ...
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Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice
... and pyruvate metabolism. Pyruvate can be produced from oxaloacetate as well as ...ACLY-mediated pyruvate be used to support lactate levels in the hippocampus in cases of limited glucose ...
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