Euglycemic-hyperinsulinemic clamp study
Transcriptomic profiles of skeletal muscle tissue following an euglycemic-hyperinsulinemic clamp in insulin-resistant obese subjects
... the hyperinsulinemic clamp method allows the individual effect of insulin to be studied (Rome et ...current study is to explore the changes in gene expression levels associ- ated with glucose, fatty ...
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Intraocular pressure and aqueous humor flow during a euglycemic-hyperinsulinemic clamp in patients with type 1 diabetes and microvascular complications
... The rapid IOP fall in patients with type 1 diabetes in response to intravenous insulin is a novel finding. This is the period of equilibration of insulin in the peripheral tis- sues. The IOP reduction during this time ...
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The Effects of a Hyperinsulinemic Euglycemic Clamp on Milk Fat Synthesis and the Expression of Fat Synthesis Related Genes in the Mammary Gland Tissues of Lactating Goats
... the hyperinsulinemic-euglycemic clamp procedure was performed in lactating goats in the present ...the hyperinsulinemic-euglycemic clamp on milk yield, milk composition, milk ...
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Reduction in peripheral vascular resistance predicts improvement in insulin clearance following weight loss
... our study is that improvement in vascular parameters (reduction in calf vascular resist- ance and increase in finger reactive hyperaemic index), independent of weight changes, delineated those subjects who gained ...
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Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons
... the study of human disease, because of their close genetic and physio- logic similarity to man ...the hyperinsulinemic euglycemic clamp technique, we characterized the baboon as a model of ...
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A mathematical model of the euglycemic hyperinsulinemic clamp
... the Euglycemic Hyperinsulinemic glucose Clamp was performed according to ...five-hour clamp procedure, the glucose and insu- lin levels were monitored every 5 min and every 20 min ...
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Acute exercise alters skeletal muscle mitochondrial respiration and H 2emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men
... insulin clamp observed in the present study. The lower muscle GSH content following the post-exercise insulin clamp (Fig 4) suggests that some perturbation to muscle redox homeosta- sis occurred. ...
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<p>Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects</p>
... during hyperinsulinemic-euglycemic ...present study, of the two simple markers, the Matsuda index was a relevant surrogate index of insulin sensitivity based on the correlation derived from glucose ...
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Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats
... Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We ...
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Blood pressure in Warmblood horses before and during a euglycemic-hyperinsulinemic clamp
... All of these factors promote a rise in blood pressure and in the long run cause hypertension. An altered vascular response to insulin leading to an increase in vascular tone could perhaps explain the described increase ...
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Effect of Linagliptin and Voglibose on metabolic profile in patients with Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial
... Fasting plasma glucose (FPG), C-peptide, homeostasis model assessment estimated insulin resistance index (HOMA-IR), homeostasis model assessment β-cell function index (HOMA-β) and hyperinsulinemic ...
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Glucose Intolerance in Uremia: QUANTIFICATION OF PANCREATIC BETA CELL SENSITIVITY TO GLUCOSE AND TISSUE SENSITIVITY TO INSULIN
... Hyperglycemic clamp. The blood glucose concentration was acutely raised and maintained 125 mg/dl above basal levels for 2 h. Since the glucose concentration was held constant, the glucose infusion rate is an index ...
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Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease A study with positron emission tomography
... prospective study has documented a significantly higher risk for ischemic heart disease in hyperinsulinemic Canadian men independently of serum triglycerides, cholesterol fractions, and apolipoprotein B ...
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Effects of exercise training on in vivo insulin action in individual tissues of the rat
... the euglycemic clamp with administration of glucose tracers, [3H]2-deoxyglucose (2DG), [14C]glucose, and [3H]glucose, in vivo insulin action at the whole body level and within individual tissues has been ...
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Insulin stimulation of adipose tissue lipoprotein lipase Use of the euglycemic clamp technique
... The role of insulin in the regulation of adipose tissue lipoprotein lipase activity in humans was investigated in 11 normal subjects and compared with the effects of 0.9% saline infusions in five control subjects. After ...
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Glucagon-like peptide-1 protects against ischemic left ventricular dysfunction during hyperglycemia in patients with coronary artery disease and type 2 diabetes mellitus
... A standard clinical protocol for DSE was used. Subjects attended for both studies after an overnight fast and their beta-blocker was withheld for 48 h prior to their attendance. Oral hypoglycemic agents were omitted on ...
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Effect of beta and alpha adrenergic blockade on glucose induced thermogenesis in man
... microunits/ml) clamp study (n = 12); (b) insulin clamp study after beta adrenergic blockade with intravenous propranolol for 1 h (n = 12); (c) insulin clamp study after alpha ...
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Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
... tion with insulin therapy in individuals with T2DM significantly improves insulin-mediated glucose disposal (10, 11). However, these latter studies are difficult to interpret, since insulin therapy also exerts other ...
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Insulin resistance and hypersecretion in obesity European Group for the Study of Insulin Resistance (EGIR)
... however, nonlinear, with most of the decrement in insulin sen- sitivity occurring for small increments in BMI. In other studies of insulin resistance in obesity, the groups were generally too small to assess its ...
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Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists
... insulin-resistant study groups in man. In terms of human studies, TZDs have been most extensively eval- uated in patients with type 2 diabetes. Initial clinical research studies with TZDs clearly demonstrated that ...
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