eukaryotic initiation factor 4E
The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... translation factor, eukaryotic initiation factor 4E (eIF-4E) in infected and transfected ...translation factor led us to investigate whether Z could modulate host cell ...
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Original Article Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis
... translation initiation in the genesis and maintenance of multiple types of cancer is becoming ...the eukaryotic initiation factor 4E (eIF4E) which is the rate limiting component of the ...
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Eukaryotic initiation factor 4E 3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila
... that 4E-BP physically interacts with eIF4E-1 but not with eIF4E-3 in ... 4E-BP interacts with eIF4E-1, -2, -4 and -5, but not with eIF4E-3, in the yeast two-hybrid ...system. 4E-HP and eIF4E-6 were ...
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Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... Interaction of plant viruses with the host translation machin- ery and its consequence on protein synthesis has not been intensively investigated (4). Recently, inhibition of host gene expression has been associated with ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... Differential expression of LeishIF4E under different envi- ronmental conditions. Stage-specific gene expression in Leish- mania is controlled by the 3 ⬘ UTR (3, 30, 44, 50, 65), and an FIG. 5. None of the LeishIF4E ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... of eukaryotic initiation fac- tor (eIF) 4E activity slows G1 progression in yeast [13] and non-transformed mammalian cells ...translation initiation and is thought to function through eIF4F, a ...
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Effects of leucine and its metabolite β hydroxy β methylbutyrate on human skeletal muscle protein metabolism
... 4EBP1, eukaryotic initiation factor 4E binding protein 1; α -KIC, α -ketoisocaproate; AA, amino acid; AKT, protein kinase B; APE, atom percent excess; BCAA, branched-chain amino acid; BCAT, ...
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Effects of oral phosphatidic acid feeding with or without whey protein on muscle protein synthesis and anabolic signaling in rodent skeletal muscle
... hyper-phosphorylating eukaryotic initiation factor 4E (eIF4E)-binding proteins (4EBP-1/2); c) activated p70s6k phosphorylates and activates ribosomal protein s6 (rps6), while ...
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Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and ...of eukaryotic ...
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Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs
... modulate skeletal muscle protein synthesis and how this changes with development. In the current study, we identified mechanisms involved in protein degradation regulation. In experiment 1, 6- and 26-d-old pigs were ...
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PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability
... that eukaryotic initiation factor 4E-binding protein 1(4E-BP1) was highly regulated by ...that 4E-BP1 up-regulation correlates with increased PC-1 expression in human prostate ...
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Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... fide initiation factor performing the function of a scaffold in the translation initiation complex of ...translation initiation in Giardia (unpublished data), whereas homologues of eIF4B and ...
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Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in gastrocnemius and masseter muscles (P < ...and 4E-BP1 phosphorylation were completely ...
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Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...translation initiation factor 2 ␣ (eIF2 ␣ ) on serine 51 ...
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Taking aim at translation for tumor therapy
... Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have ...
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Visualization of the Interaction between the Precursors of VPg, the Viral Protein Linked to the Genome of Turnip Mosaic Virus, and the Translation Eukaryotic Initiation Factor iso 4E In Planta
... Nuclear localization of the interaction between VPg-Pro and eIF(iso)4E was visualized in the absence of other viral pro- teins. In an attempt to confirm the presence of VPg-Pro and eIF(iso)4E in the nucleus ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... translation initiation have not yet been well es- tablished, and none of these proteins has been identified so ...translation initiation, which pro- ceeds in several steps and depends on at least 12 ...
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MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling
... 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein 1; AECs: Airway epithelial cells; AKT: Protein kinase B; CPE: Cytopathic effect; EC50: Half maximal effective ...
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Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
... the initiation step of the protein ...the initiation process by interacting with ribosomal subunits and mRNAs to form an elongation competent complex ...
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