EV-A71
Valine/isoleucine variants drive selective pressure in the VP1 sequence of EV A71 enteroviruses
... the EV-A71 polyprotein at the level of the VP1 protein was shown to be crucial for increasing the strength of protein-protein interactions in the capsid and its ...the EV-A71 isolates analyzed ...
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Hypoxia and therapeutic treatment of EV-A71 with an immune modulator TLR7 agonist in a new immunocompetent mouse model
... in EV-A71-infected wt-129 ...of EV-A71 developed necrotizing myositis of the respiratory muscle, and caused severe hypoventilation by monitoring respiratory functions ...our ...
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Human tryptophanyl tRNA synthetase is an IFN γ–inducible entry factor for Enterovirus
... with EV-A71 infections in humans, including those associated with severe neu- rological ...by EV-A71 ...by EV-A71 challenge in neo- natal ...right; EV-A71– infected ...
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Exosomal MicroRNA-155 Inhibits Enterovirus A71 Infection by Targeting PICALM
... in EV-A71 infection, we isolated exosomes from the supernatants of uninfected and EV-A71 infected rhabdomyosarcoma (RD) ...from EV-A71-infected and mock-infected cells was ...
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Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China
... of EV than the control group ...severe EV infections based on evidence of a possible significant bene- fit through the reduction of the associated central nervous system (CNS) inflammatory response ...in ...
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Suppression of interleukin-6 increases enterovirus A71 lethality in mice
... of EV-A71 strain M2 by intraperitoneal ...1a). EV-A71 infection significantly increased mouse serum IL-6 levels from days 2 to 6 ...1b). EV- A71 infection significantly increased ...
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Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014
... In total, 210 clinical samples were collected in Chongqing City in 2014. Viruses were isolated from the original clin- ical specimens by propagation in human rhabdomyosar- coma (RD) and human larynxarcinoma (HEp-2) cells ...
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Enterovirus A71 Infection Activates Human Immune Responses and Induces Pathological Changes in Humanized Mice
... in EV-A71-infected patients was found to be associated with the local production of proinflammatory cytokines, and a number of clinical reports also suggested that an increase in serum IFN- ␥ , IL-6, IL-10, ...
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Molecular characterization of enterovirus A71 in children with acute flaccid paralysis in the Philippines
... only EV-A71 gen- ogroup C, in particular, subgenogroup C2 in 2002 and subge- nogroup C2-like in 2000, 2002, 2005, and 2010 in different geographic locations in the Philippines ...other EV-A71 ...
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Mapping Enterovirus A71 Antigenic Determinants from Viral Evolution
... several EV-A71 vaccines have been progressively de- veloped, and clinical trials are being or have been performed in China (phase III), Taiwan (phase I), and Singapore (phase I) (re- viewed in reference ...
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Squamous epitheliotropism of Enterovirus A71 in human epidermis and oral mucosa
... In EV-A71-infected prepuce skin organotypic cultures, the highest viral titers were observed at 2 dpi which significantly dropped after 4 dpi suggesting that virus was probably most actively replicating ...
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Validation and utilization of an internally controlled multiplex Real time RT PCR assay for simultaneous detection of enteroviruses and enterovirus A71 associated with hand foot and mouth disease
... and EV-A71 in clinical ...and EV-A71 are tested simultan- eously) and is therefore useful for clinical management and outbreak response of ...
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The History of Enterovirus A71 Outbreaks and Molecular Epidemiology in the Asia-Pacific Region
... other EV- A71 subgenotypes in circulation remains another con- ...against EV-A71/CV-A6/ CV-A16 could provide additional benefits towards the reduction of HFMD ...venting EV-related ...
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Enterovirus A71: virulence, antigenicity, and genetic evolution over the years
... region had been found to increase viral fitness (Fig. 1) [66]. The 3C region has been reported to be able to interfere with the host innate defense by selectively inhibiting the synthesis of type I interferon (IFN), and ...
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Phylodynamics of Enterovirus A71-Associated Hand, Foot, and Mouth Disease in Viet Nam
... EV-A71), given the seemingly rapid and large epidemic experi- enced in Viet Nam, although they are robust to a variety of prior distributions for the input parameters. Nonetheless, our observa- tional data ...
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Enterovirus A71 neurologic complications and long-term sequelae
... of EV-A71 infection [11] and it has lowered the case-fatality rate of severe EV-A71 cases signifi- cantly [18], but long-term sequelae are of great con- cerns, especially in young ...
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Recent advances on the role of host factors during non-poliovirus enteroviral infections
... of EV-A71 and CV-A16; there is need to understand pathogenesis of the infec- tions as well as quantifying their burden for easy disease ...and EV-A71 have been broadly studied; however little ...
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Original Article Extensive phagocytosis in non-viral-infected neurons observed in enterovirus A 71-infected cases
... by EV-A71 demon- strated that inflammation was most marked in spinal cord gray matter, brainstem, hypothala- mus, and subthalamic and dentate nuclei with lesions of perivascular cuffs, variable edema, ...
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A Selective Bottleneck Shapes the Evolutionary Mutant Spectra of Enterovirus A71 during Viral Dissemination in Humans
... with EV-A71 ...other EV-A71 strains while infecting human hosts, we collected 15 additional EV-A71 strains, 7 of which were isolated from fatal cases and 8 of which were from ...
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Interplays between Enterovirus A71 and the innate immune system
... Enterovirus A71 (EV-A71) is a growing threat to public health, particularly in the Asia-Pacific ...region. EV-A71 infection is most prevalent in infants and children and causes a wide ...
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