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Evidence from animal studies

Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

Facilitating healthcare decisions by assessing the certainty in the evidence from preclinical animal studies

... reported animal stud- ies were necessary for a more valid estimation of the treatment effect in ...going from evidence to ...of animal studies is a topic for further ...potential, ...

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Stress and Childhood Asthma Risk: Overlapping Evidence from Animal Studies and Epidemiologic Research

Stress and Childhood Asthma Risk: Overlapping Evidence from Animal Studies and Epidemiologic Research

... 52–54 Studies in both rodents and primates have shown that environmental manipula- tions that increase maternal stress result in elevated cortisol levels and dysfunctional behaviours in offspring that are evident ...

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Minisymposium. Towards Evidence Based Translational Research. The Pros and Cons of Performing Systematic Reviews of Animal Studies

Minisymposium. Towards Evidence Based Translational Research. The Pros and Cons of Performing Systematic Reviews of Animal Studies

... Since the seventies of the previous century the number of experiments using animals in the Netherlands has seen an ongoing decrease. The last few years however, this number stays roughly the same (about 575.000 ...

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It is well documented from animal studies that during the perinatal

It is well documented from animal studies that during the perinatal

... conflicting evidence on the effects of aging on the number of granule neurons, and the reasons for which variations in this number may or may not have occurred remain unknown ...

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Certificate II in Animal Studies

Certificate II in Animal Studies

... To be enrolled in this course, you need to be able to provide evidence that you have: completed an Animal Care Application form. Completed application forms are forwarded to the head teacher for screening. ...

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Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

... The studies presented in the present review provide compelling evidence that aortic ED is impaired during the severe inflammatory phase of the AIA model, in agreement with the presence of a macrovascular ED ...

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The Potential of Adaptive Design in Animal Studies

The Potential of Adaptive Design in Animal Studies

... in Animal Studies In an evaluation of adaptive design strategies for clinical trials, Lewis and Berry tested their applicability to animal studies as well ...Results from a traditional ...

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Resveratrol and diabetes: from animal to human studies

Resveratrol and diabetes: from animal to human studies

... A large body of evidence indicates that resveratrol exerts also anti-diabetic action in animal models of type 2 diabetes. It is known that resveratrol improves pancreatic islet structure and function and ...

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The impact of outdoor air pollution on COVID-19: a review of evidence from in vitro, animal, and human studies

The impact of outdoor air pollution on COVID-19: a review of evidence from in vitro, animal, and human studies

... mentioned studies were ecological and cross-sectional, individual-level inferential statements cannot be ...ecological studies have an inherent internal validity threat, unmeasured confounding ...comes ...

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The genomics of preterm birth: from animal models to human studies

The genomics of preterm birth: from animal models to human studies

... findings from model organisms that have defined components of birth timing mechanisms for those species, and the evidence for variable maternal and fetal contributions to the process depending upon the ...

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Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

Insights into Alzheimer disease pathogenesis from studies in transgenic animal models

... strong evidence for the toxicity of soluble Ab oligomers in vivo by showing that many pathological and functional changes in mice occur before the appearance of Ab plaque ...example, studies in PDAPP mice ...

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Collective animal navigation and migratory culture: From theoretical models to empirical evidence

Collective animal navigation and migratory culture: From theoretical models to empirical evidence

... Experiments can also be performed outside of the labora- tory. One fruitful method is to take advantage of the natural homing behaviour in some animals. In such cases, group size and composition can be easily manipulated ...

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Studies on Animal Carotenoids

Studies on Animal Carotenoids

... Most of the carotenoid containing chromatophores, however, develop in the skin of the posterior end of the body, particularly on the tail and adipose fins, and the similarity between the[r] ...

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Studies on Animal Carotenoids

Studies on Animal Carotenoids

... oxide or calcium carbonate and developed with 2 % methanol in petroleum ether, the hypophasic fraction usually separated into the following bands: (1) one or more trace bands at the top [r] ...

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Studies in Animal Locomotion

Studies in Animal Locomotion

... The motion of a typical segment can be followed diagrammatically in Text- figs. The wave, as seen in its initial position on the right side of Text-figs. 2 and 4, is arbitrarily composed[r] ...

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Studies In Animal Locomotion

Studies In Animal Locomotion

... The elicitation of an ambulatory rhythm in response to stretch was first demon- strated by Friedlander (1888) who showed that if the posterior half of a worm be severed from the anterior[r] ...

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Studies in Animal Locomotion

Studies in Animal Locomotion

... If separate electrodes are used for the stimulation of the two sides of the cord and one of the electrodes be removed when the reversed swimming reaction is being elicited, the posterior[r] ...

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Studies in Animal Locomotion

Studies in Animal Locomotion

... Tracing of tension developed when the body of a decapitated eel (wt. 8 oz.) was in contact with three pegs situated as in Text-fig: 1 C and which were moved simultaneously over the body [r] ...

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Studies in Animal Locomotion

Studies in Animal Locomotion

... Before accepting an abnormally high horse-power for cetacean muscle, it is reasonable to reconsider the validity of the figure which has been accepted for the drag coefficient of the act[r] ...

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STUDIES IN ANIMAL LOCOMOTION

STUDIES IN ANIMAL LOCOMOTION

... We can now draw the important conclusion that if the waves of con- traction which pass down a fish's body appear to move backwards relative to a fixed point in the environment, the body [r] ...

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