EWS-FLI1
EWS Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells
... endogenous EWS-Fli1 enabled us to obtain identical am- plification ...efficiency. EWS-Fli1 mRNA was reproducibly quantitated in the range of 1–1,000 ...that EWS-Fli1 expression ...
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BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma
... like EWS-FLI1 remains largely ...that EWS-FLI1-mediated transcription activation might be susceptible to BET ...repressed EWS- FLI1-driven gene signatures and downregulated ...
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YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model
... of EWS-FLI1 in cells with the activated Mx1 promoter in E/F; Mx1-cre mice led to leukemia where the mice presented with severe hepatomegaly, splenomegaly, and anemia followed by rapid death ...by ...
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PI3K/AKT signaling modulates transcriptional expression of EWS/ FLI1 through specificity protein 1
... wt FLI1 did not change upon inhibition of the PI3K pathway while at the same time EWS/FLI1 mRNA expression was reduced, we hypothesized that this control of EWS/FLI1 transcription ...
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EWS erg and EWS Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations
... of EWS fusion transcripts in a series of primary Ewing's sarcomas and peripheral primitive neuroectodermal tumors and cells ...2 EWS-Fli1 fusions were demonstrated in 8 cell lines and 14 patient ...
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Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1
... the EWS-Fli1 chimeric transcription ...target EWS-Fli1 remains a central therapeutic approach to eradicate this aggressive ...directly EWS-Fli1 transcription as well as its ...
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Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1
... between EWS-FLI1 and RHA. (A) An ELISA assay measures binding between EWS- FLI1 and ...to EWS-FLI1, followed by the addition of RHA and detection with antibody (**, p < ...of ...
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EWS FLI1 employs an E2F switch to drive target gene expression
... (34). EWS-FLI1 may represent an- other such example functionally interacting with an acti- vating E2F ...between EWS-FLI1 and E2F3/pRB ...
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Downstream EWS/FLI1 - upstream Ewing's sarcoma
... when EWS/ FLI1 is turned off is mesenchymal progenitor cells (MPCs) ...of EWS/FLI1 ...of EWS/ FLI1-transformed MPCs [25] and the acquisition of ESFT-like gene expression and ...
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Long noncoding RNA EWSAT1 mediated gene repression facilitates Ewing sarcoma oncogenesis
... sarcoma. EWS-FLI1 alters gene expression through mechanisms that are not completely ...expressing EWS-FLI1 in order to identify gene targets of this ...by EWS-FLI1 in ...of ...
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Targeted, systemic non viral delivery of small interfering RNA in vivo
... 90 4.4.2 siRNA-containing polyplexes reduce expression of the EWS-Fli1 oncogene in cultured Ewing’s sarcoma cells Having demonstrated sequence-specific down-regulation of a co-delivered [r] ...
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Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9
... with EWS-FLI1 and modulates EWS-FLI1-dependent transcription ...for EWS-FLI1 by enhancing engagement of the transcriptional machinery at responsive promoters and inducing local ...
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Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development
... of EWS, TLS, and TAF15 contain degenerate repeats of the SYGQ motif and medi- ate potent transcriptional activation when fused to heterologous DNA-binding domains of different transcription factors ...of ...
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Targeting and Characterization of Dysregulations of the Aurora Kinases A and B Family Members in Ewing Sarcoma Models.
... evaluating EWS-FLI1 binding in that they included a broader evaluation of intragenic binding ...that EWS-FLI1 could bind GGAA-MR up to several hundred megabases away from the nearest gene, and ...
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Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer
... of EWS cells harboring EWS-FLI1 to PARP inhibitors was first identified in a systematic screen for genomic markers that determine drug sensi- tivity in cancer ...
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The first European interdisciplinary Ewing sarcoma research summit
... Factors associated with disease progression are of particu- lar interest as putative prognostic markers. Such biomarkers are urgently needed for early response prediction particularly in local- ized disease. Sue Burchill ...
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Cancer biomarker discovery is improved by accounting for variability in general levels of drug sensitivity in pre clinical models
... We have also included results of ElasticNet regression models when GLDS is controlled for, a method often used for constructing predictive models from these types of data (Additional file 1: Table S8); predictors ...
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Operation of the EWS in the City of Matagalpa, Nicaragua
... the EWS requires a technological component, the contribution and coordination of different social contributors, with functions and responsibilities ranging from knowledge of the risks, the vulnerabilities, the ...
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SWEET Cat update and FASMA A new minimization procedure for stellar parameters using high quality spectra
... be used for either stellar parameter derivation or the abundance method, both described below. ARES iterates over all the lines to be measured. For each line a small window is selected, where a local normalization of the ...
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miR-125b develops chemoresistance in Ewing sarcoma/primitive neuroectodermal tumor
... We have previously reported that drug-efflux pump was overexpressed in Dox-resistance cells and developed chemoresisitance [16]. An immunoblot assay revealed no changes in P-gp in the Dox-resistant cells after down- ...
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