excretion and toxicity
Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity
... excess. Toxicity classically results from inhalational exposures in individuals who work in industrial ...Mn excretion by hepatocytes and enterocytes and could be an effective target for pharmacological ...
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Root excretion and plant tolerance to cadmium toxicity a review
... Under Cd stress, tolerant species and genotypes in plant kingdom could reduce Cd activity to al- leviate or eliminate its toxicity through regulating the physiological and biochemical metabolism. In order to ...
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SYNTHESIS, ANTICANCER ACTIVITY, MOLECULAR DOCKING, AND ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION TOXICITY STUDIES OF NOVEL BENZOTHIAZINES
... Objective: A series of benzothiazine compounds were studied for absorption, distribution, metabolism, and excretion (ADME) properties to asses their drug-like properties. Compounds 1-10 with favorable ADME ...
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EFFECTS OF AMMONIA LOADING ON PORCELLIO SCABER: GLUTAMINE AND GLUTAMATE SYNTHESIS, AMMONIA EXCRETION AND TOXICITY
... (Studier, 1966). The net increase in ammonia excretion indicates a corresponding mobilization of sequestered amino groups. Much of this can be accounted for by deamination of Gln and Glu, since their ...
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Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone
... compound, using a core hopping approach, the polar head, linker, and hydrophobic tail of rosiglitazone were modified to produce various compounds. These compounds were then screened by docking and absorption, ...
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eToxPred: a machine learning-based approach to estimate the toxicity of drug candidates
... metabolism, excretion, and toxicity; CADD: computer-aided drug discovery; DBN: deep belief network; DNN: deep neural network; DUD-E: Database of Useful Decoys, Extended; ET: extra trees; FDA: Food and Drug ...
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The diverse mechanisms and anticancer potential of naphthoquinones
... ADMET: absorption, distribution, metabolism, excretion and toxicity; AIF: apoptosis‑inducing factor; AML: acute myeloid leukemia; ATF6: activating transcription factor 6; Bax: apoptosi[r] ...
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Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti-tuberculosis activity
... metabolism, excretion, and toxicity—ADMET) of the therapeutic agents and their functional effects on the human body, both on-target and off-target actions [31, ...
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ETM DB: integrated Ethiopian traditional herbal medicine and phytochemicals database
... Description: To develop ETM-DB, online research articles, theses, books, and public databases containing Ethiopian herbal medicine and phytochemicals information were searched. These resources were thoroughly inspected ...
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IN SILICO STUDIES OF FOUR ANTHRAQUINONES OF SENNA ALATA L. AS POTENTIAL ANTIFUNGAL COMPOUNDS
... the toxicity, the selected anthraquinone compounds showed class II (50mg/kg - 500mg/kg) or Class III (500mg/kg - 5000mg/kg)acute oral toxicity which is the indication of their lower toxic ...acute ...
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Ammonia excretion in aquatic invertebrates: new insights and questions
... ammonia toxicity of fishes can be found in review articles by Eddy (2005), Ip and co-workers (Ip et ...Ammonia toxicity has also been documented in several aquatic invertebrates, particularly commercially ...
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Polyphenols excretion reduces lipids peroxidation, hyperuricemia and hypercholesterolemia in type 2 tunisian diabetics
... power against oxidative stress Moreover, green or black tea is a popular beverage in Tunisia as well as in other North African countries like Libya or Algeria. In vitro, animal and some clinical trials, whatever ...
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STUDIES ON THE FUNCTIONAL CAPACITY OF A DENERVATED HOMOTRANSPLANTED KIDNEY IN AN IDENTICAL TWIN WITH PARALLEL OBSERVATIONS IN THE DONOR
... Water excretion Three different stimuli employed in the recipient to study water excretion independent of the electrolyte excretion evoked changes: 1 infusion of Pitressin@ produced a pr[r] ...
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THE RENAL EXCRETION OF CITRATE
... when the urine is made alkaline by bicarbonate feeding in the absence of acetazolamide, an increased citrate excretion results; but in experiments in which acetazolamide and bicarbonate [r] ...
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The Renal Excretion of Oxypurines
... If we assume that the endogenous creatinine clearance approximates inulin In clearance in the absence of frank renal failure 13, the clearance ratio for oxypurines Co,/Ccr in the xanthin[r] ...
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Pharmacokinetics, absorption, and excretion of radiolabeled revexepride: a Phase I clinical trial using a microtracer and accelerator mass spectrometry-based approach
... Keywords: accelerator mass spectrometry, gastroesophageal reflux disease, pharmacokinetics, revexepride, 5-hydroxytryptamine receptor 4 agonist2. Introduction.[r] ...
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Direct Measurement of Osteolysis in Man
... of total calcium intake, v., net dietary calcium absorption rate, v., urinary calcium excretion rate, VF, total fecal calcium excretion rate, vf, net endogenous fecal excretion rate, V12[r] ...
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Nitrogen Excretion in Ascidiacea II Storage Excretion and the Uricolytic Enzyme System
... The renal concretions of AscuMa irigra and Phallusia mammillata contain 5060 % uric acid, the remainder of the concretion is unidentified but is non-nitrogenous and is not calcium carbon[r] ...
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Glucose reabsorption from bile Evidence for a biliohepatic circulation
... indicating that entry of glucose and 3-O-MG into hepatocyte water was not limiting. Furthermore, when sodium dehydrocholate augmented canalicular secretion, biliary glucose excretion increased proportionally ...
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OBSERVATIONS ON THE ACIDIFYING CAPACITY OF THE EXPERIMENTALLY DISEASED KIDNEY IN THE DOG
... Thus, both total hydrogen ion secretion estimated as ammonium excretion + titratable acid excretion + bicarbonate reabsorption, and net hydrogen ion excretion estimated as ammonium excre[r] ...
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