Experimental Autoimmune Encephalomyelitis
Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation
... Abbreviations used in this paper: ConA, concanavalinA; CR-EAE, chronic relapsing experimental autoimmune encephalomyelitis; CY, cyclophosphamide; GMBP, guinea pig myelin basic protein; L[r] ...
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Schubart, Anna (2002): Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE). Dissertation, LMU München: Fakultät für Biologie
... Type I and II lesions show a striking resemblance to the lesions seen in certain models of experimental autoimmune encephalomyelitis (EAE), an animal model of MS initiated by an autoimmune ...
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1,25 dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis
... The hormone, 1,25-dihydroxyvitamin D3 (1,25-[OH]2-D3), inhibits lymphocyte activation in vitro. We studied the ability of the vitamin D metabolite to interfere in vivo with a primary T cell-mediated model of ...
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IL 23 produced by CNS resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
... CNS-resident cells, in particular microglia and macrophages, are a source of inflammatory cytokines during inflammation within the CNS. Expression of IL-23, a recently discovered cytokine, has been shown to be critical ...
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The role of innate immune cells in the pathogenesis of experimental autoimmune encephalomyelitis
... "IFN-y-producing natural killer cells are pathogenic in experimental autoimmune encephalomyelitis by promoting Ml macrophage activation and VLA-4 expression on 004"^ T cells" - Internati[r] ...
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A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT
... In studies using genetically deficient mice, a role for the lymphotoxin (LT) system in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) has remained controversial. Here, we have ...
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RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis
... an autoimmune, neurodegenerative ...regulating autoimmune responses, we evaluated RGS10-null and wild-type (WT) mice for susceptibility to experimental autoimmune encephalomyelitis ...
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Compensatory Neuroprotective Response of Thioredoxin Reductase Against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
... Cortical theta burst stimulation (TBS) structured as intermittent (iTBS) and continuous (cTBS) could prevent the progression of the experimental autoimmune encephalomyelitis (EAE). The interplay of ...
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The role of T cell subsets in experimental autoimmune encephalomyelitis
... Due to the complex environmental and genetic factors influencing MS, the pathogenesis of this disease is still poorly understood. In order to elucidate the causes and to develop new therapies, an animal model for MS was ...
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T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
... involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific ...
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Translational utility of experimental autoimmune encephalomyelitis: recent developments
... complex autoimmune condition with firmly established genetic and environmental ...MS, experimental autoimmune encephalomyelitis (EAE), has been instrumental in understanding immunity in ...
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The circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis
... model, experimental autoimmune encephalomyelitis (EAE), immune cells migrate from the blood stream into the CNS parenchyma and into the cerebrospinal fluid (CSF) ...
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<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>
... Experimental autoimmune encephalomyelitis (EAE) is a common animal model used to study MS. In regular EAE induction, myelin oligodendrocyte peptide (MOG) is emulsified with adjuvant and then injected ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... rodent experimental autoimmune encephalomyelitis (EAE) models of MS suggest PLA2 enzymes are involved in the onset and genesis of this dis- ease ...the autoimmune response and EAE clinical ...
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CD28 independent induction of experimental autoimmune encephalomyelitis
... Activation of mature T lymphocytes requires antigen recognition and costimulatory signals, but the require- ments for T-cell anergy and apoptosis are more contro- versial. Earlier reports suggested that antigen recogni- ...
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The Effect of Aqueous Extract of Tarragon on Clinical Symptoms and T Cell Differentiation in Experimental Autoimmune Encephalomyelitis
... on experimental autoimmune encephalomyelitis (EAE), the spleen of mice were removed and the cells were analyzed by intracellular staining of interferon γ (IFN-γ), Interleukin 17 (IL-17A), and ...
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Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis
... an experimental model of MS, experimental allergic encephalomyelitis (EAE), where blood – brain barrier disruption and vascular remodelling appeared in a pre-symptomatic disease ...
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Immunosuppressive activity of 13 cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats
... Some activities of retinoids on cellular and humoral immunity have been described, but the available data are conflicting or obtained at concentrations that are toxic in vivo. In this study, we demonstrate that ...
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IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis
... of experimental collagen- induced arthritis (CIA) ...autoantibody-mediated autoimmune disease mouse mod- els of CIA [41], lethal IgG-driven immune thrombocyto- penic purpura (ITP), autoimmune ...
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Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis
... To examine the mechanisms of autoimmunity to neu- rons we have developed a model of autoimmune induced axonal and neuronal damage following immunization of mice with the neuronal cytoskeletal protein neurofilament ...
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