Experimental autoimmune encephalomyelitis (EAE)
Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... rodent experimental autoimmune encephalomyelitis (EAE) models of MS suggest PLA2 enzymes are involved in the onset and genesis of this dis- ease ...the autoimmune response and ...
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<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>
... Experimental autoimmune encephalomyelitis (EAE) is a common animal model used to study ...regular EAE induction, myelin oligodendrocyte peptide (MOG) is emulsified with adjuvant and ...
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Compensatory Neuroprotective Response of Thioredoxin Reductase Against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
... the experimental autoimmune encephalomyelitis ...by EAE has not been entirely investigated, just as the effect of iTBS or cTBS on oxidative-nitrogen stress (ONS) in EAE ...of EAE ...
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IL 23 produced by CNS resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
... CNS-resident cells, in particular microglia and macrophages, are a source of inflammatory cytokines during inflammation within the CNS. Expression of IL-23, a recently discovered cytokine, has been shown to be critical ...
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Schubart, Anna (2002): Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE). Dissertation, LMU München: Fakultät für Biologie
... of experimental autoimmune encephalomyelitis (EAE), an animal model of MS initiated by an autoimmune response to CNS myelin ...of EAE, in which demyelination is antibody mediated ...
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Effects of Bu Shen Yi Sui Capsule on Th17/Treg cytokines in C57BL/6 mice with experimental autoimmune encephalomyelitis
... sclerosis; EAE: Experimental autoimmune encephalomyelitis; TGF: Transforming growth factor; ROR: Retinoic acid-related orphan receptor; FoxP3: Forkhead box P3; PA: Prednisone acetate; TCM: ...
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Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
... of EAE mice, we performed next-generation sequencing (NGS) of DRGs taken from mice at the onset of the dis- ease when pain hypersensitivity is evident [2, 3, ...to EAE both in female (3520 DEGs) and male ...
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Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents
... and EAE animals [57] have been extensively investi- gated, their affinity to SVZ area and cross-linking to NPCs have not been ...that EAE-AS has an impact on NPCs through activation of the apoptotic ...in ...
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Immunosuppressive activity of 13 cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats
... achieved in vivo, further suggesting that the prevention of EAE was due to a suppressive activity on T cell-mediated immunity. The immunosuppressive activity of 13-cRA included suppression of interleukin 2, whose ...
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Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation
... immunosuppressive regimens (cyclophosphamide [CY] 300 mg/kg or total body irradiation [TBI] 900 cGy) followed by syngeneic bone marrow transplantation (SBMT) in prevention and treatment of already established ...
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... investigated. Experimental autoimmune encephalomyelitis (EAE), an in vivo model of MS, was induced in female C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein ...
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Original Article Cytoprotective effects of high dose of -galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant
... Methods: Experimental autoimmune encephalomyelitis (EAE) was induced using adoptive transfer of MOGCD4+ cells treated using α-GC into recipient C57BL/6 mice while the MOGCD4+ cells treated ...
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Multiple sclerosis
... an autoimmune, at times demyelinating, disease in mammals with immunization of CNS myelin (experimental autoimmune encephalomyelitis, or EAE), first made by Thomas Rivers at the ...
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Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
... with experimental autoimmune encephalomyelitis (EAE), a model of MS, have shown that ON is accompanied by presence of macrophages [7] and T cells [8] in the optic nerve, and strategies aimed ...
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Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis
... of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are significantly more severe than in wild-type mice with ...limiting autoimmune brain inflamma- tion, which ...
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Neuroimmune interaction between multiple sclerosis and inflammatory bowel disease
... As experimental autoimmune encephalomyelitis (EAE) studies have shown Multiple Sclerosis is a TH1 CD4+ cells mediated disease, the immunologic cascade starts with the activation of the innate ...
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Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker
... albumin; EAE: experimental autoimmune encephalomyelitis; GAPDH: glyceraldehydes-3- phosphate dehydrogenase; GLK: germinal center kinase-like kinase; HC: healthy control; IL: interleukin; IQ: ...
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Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination
... It has previously been shown that co-injection of anti- MOG induced demyelination in an otherwise non- demyelinating uniphasic EAE model in Lewis rats [21]. Demyelination was observed in the perivascular cuffs and ...
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Pleiotropic Immune Functions of Chemokine Receptor 6 in Health and Disease
... of experimental stroke, genetic deficiency in Ccr6 was associated with diminished infiltration of natural IL-17 releasing γδ T cells and a significantly improved neurological outcome, outlining the role CCR6 plays ...
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“Microglial nodules” and “newly forming lesions” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model
... both autoimmune and viral models. These experimental findings are consistent with early MS pathology described by both the Singh and the Barnett groups, and support that MGNs and NFLs can be an early MS ...
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