Experimental autoimmune neuritis
Accumulation of Fascin+ cells during experimental autoimmune neuritis
... Experimental autoimmune neuritis (EAN) is an autoantigen-specific T-cell mediated inflammatory de- myelinating disease of the peripheral nervous system (PNS), which is characterized by weight loss, ...
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The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain–Barré syndrome
... Experimental autoimmune neuritis (EAN) is an estab- lished animal model of acute inflammatory demyelinating polyradiculoneuropathy, or GBS. Rodent models of EAN can be established using injections of ...
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Original Article Myelin ultrastructure of sciatic nerve in rat experimental autoimmune neuritis model and its correlation with associated protein expression
... Abstract: To explore the relationship of peripheral nerve ultrastructure and its associated protein expression in experimental autoimmune neuritis (EAN). EAN was established in Lewis rats using an ...
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Fingolimod attenuates experimental autoimmune neuritis and contributes to Schwann cell-mediated axonal protection
... Methods: We tested fingolimod in the animal model of experimental autoimmune neuritis in Lewis rat. Six to eight-week-old female rats were immunized with P2 peptide and from this day on treated with ...
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Trapped in the epineurium: early entry into the endoneurium is restricted to neuritogenic T cells in experimental autoimmune neuritis
... detail. Experimental autoimmune neuritis (EAN) induced in Lewis rats by myelin homogenates, or peptides of peripheral myelin components such as protein 2 (P2), is a well-defined animal model of a ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... DMF has been demonstrated to reduce inflammation in autoimmune and inflammatory animal models [23, 24, 33, 41–44]. In accordance with previous reports, the present study showed that DMF reduced the inflammatory ...
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Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
... Results: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in ...
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FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
... mental autoimmune neuritis (c-EAN) that can be easily and reliably induced by active immunization of Lewis rats with the P0(180–199) peptide thiopalmitoylated (S-palm P0(180–199)) at cysteine 181 [13, 14], ...
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Intrathecal triamcinolone acetonide exerts anti-inflammatory effects on Lewis rat experimental autoimmune neuritis and direct anti-oxidative effects on Schwann cells
... Furthermore, IL-1Ra production was reduced after SC incubation with TRIAM. Experiments on sciatic nerves of EAN rats after immunization with P2 and after adop- tive transfer of effector T cells have shown that in both ...
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Enhanced glycolysis contributes to the pathogenesis of experimental autoimmune neuritis
... It is believed that high glycolysis not only meets the increased energy demand but also provides adequate biosynthetic precursors for proteins, lipids, and nucleic acids in the process of cell activation, proliferation, ...
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Capsaicin-enriched diet ameliorates autoimmune neuritis in rats
... Methods: We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive ...
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CD28 independent induction of experimental autoimmune encephalomyelitis
... Activation of mature T lymphocytes requires antigen recognition and costimulatory signals, but the require- ments for T-cell anergy and apoptosis are more contro- versial. Earlier reports suggested that antigen recogni- ...
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Modelling neuroinflammatory phenotypes in vivo
... Activated microglia are also a typical part of the brain's inflammatory response. Although TGF-β1 is generally considered an anti-inflammatory cytokine, it has been associated with recruitment of monocytes to the site of ...
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Retinal pathology in experimental optic neuritis is characterized by retrograde degeneration and gliosis
... matory autoimmune response on the myelinated portion of the optic nerve in early stages, whereas, IRL thinning observed later in the disease is thought to reflect axonal loss, neurodegeneration, or retrograde ...
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Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease
... oplastic autoimmune autonomic neuropathy, the severity parallels serum levels of ganglionic nAChR ...including autoimmune autonomic neuropathy, seizures, dementia, and movement ...
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Autoimmune responses against cultivated thyrocytes
... Xll FOR EXPERIMENTAL AUTOIMMUNE THYROIDITL~ 5.1 Introduction 80 5.2 The regulation of autoimmune thyroiditis by lymphocytes from normal, 84 self-tolerant animals 5.2.1 Negative regulatio[r] ...
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T-cell recognition in experimental autoimmune thyroiditis
... of autoimmune thyroiditis in man requires the activation of multiple cell types such as Tc cells and Th cells and one of the activating determinants namely thyroxine containing peptide is present in the periphery ...
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Proteasome inhibitors as experimental therapeutics of autoimmune diseases
... cytokine and cell cycle regulation and apoptosis, renders it crucial in the development and progression of inflam- matory and autoimmune diseases [5]. Given that cytokines are regulatory factors in the formation ...
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Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis
... an experimental model of MS, experimental allergic encephalomyelitis (EAE), where blood – brain barrier disruption and vascular remodelling appeared in a pre-symptomatic disease ...
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Reprogramming The Retina: Next Generation Strategies Of Retinal Neuroprotection And Gene Therapy Vector Potency Assessment
... Mutations within over 250 known genes are associated with inherited retinal degeneration. Clinical success following gene replacement therapy for Leber’s congenital amaurosis type 2 establishes a platform for the ...
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