Experimental autoimmune uveitis
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
... Experimental autoimmune uveitis (EAU) is a disease of the neural retina induced by immuniza- tion with retinal antigens, such as interphotoreceptor retinoid-binding protein (IRBP) and arrestin ...
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IL-33 attenuates the development of experimental autoimmune uveitis
... disease. Experimental autoimmune uveitis (EAU) in the mouse closely resembles the pathology of human posterior intraocular inflam- matory conditions such as sympathetic ophthalmia, sarcoidosis, and ...
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Retroviral gene therapy with an immunoglobulin antigen fusion construct protects from experimental autoimmune uveitis
... of experimental autoimmune uveitis, a cell-mediated autoimmune disease model for human uveitis induced with the uveitogenic interphotoreceptor retinoid-binding protein ...
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KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
... human autoimmune uveitis is not fully understood, the associ- ation between the development of uveitis and Th cell re- sponses has been established as a vital contributor to the etiology of ...
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MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis
... EAE: Experimental autoimmune encephalomyelitis; EAU: Experimental autoimmune uveitis; FACS: Fluorescence-activated cell sorting; FC: Flow cytometry; FDR: False discovery rate; FMO: ...
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Cyclosporin a Inhibition of experimental autoimmune uveitis in Lewis rats
... demonstrate cell mediated responses to this antigen. Daily treatment with CS-A (10 mg/kg) begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental ...
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Kaufmann, Ulrike (2013): Immunoregulation of monophasic and relapsing experimental autoimmune uveitis in the rat model. Dissertation, LMU München: Medizinische Fakultät
... autoimmune uveitis. When we investigated the Foxp3 expression of intraocular T cells during the course of disease, an increase in the number of Foxp3 + T cells was found at the resolution of monophasic EAU. ...
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T cell effector mechanisms in experimental autoimmune uveitis (EAU)
... It has been shown that administration of TGF-p can prevent the occurence of some autoimmune diseases [Johns et al., 1991; Kuruvilla et al., 1991; Racke et al., 1991]. As the clearance of circulating active TGF-p ...
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Bromocriptine and low dose cyclosporine in the treatment of experimental autoimmune uveitis in the rat
... Bromocriptine alone decreased the incidence of EAU only in female rats P < 0.01, did not effect the lymphocyte proliferative response, but did significantly decrease antibody titers in b[r] ...
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Oxidative photoreceptor cell damage in autoimmune uveitis
... Abstract Uveitis comprises an extensive array of intraocular inflammatory diseases and often results in irreversible visual ...loss. Experimental autoimmune uveitis (EAU) is an animal model ...
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HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent
... organ-specific autoimmune disease. In experimental autoimmune uveitis (EAU) induced by adoptive transfer of interphotoreceptor retinoid-binding protein (IRBP)-specific T cells in mice, we have ...
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Inhibition of T cell mediated inflammation in uveitis by a novel anti CD3 antibody
... in uveitis. Methods: Experimental autoimmune uveitis (EAU) was induced in mice by immunization with retinal peptides, followed by administration of ...
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Evaluation of intravitreal injection of pentoxifylline in experimental endotoxin-induced uveitis in rabbits
... report about evaluation of clinical and histopathological effects of intravitreal injection of PTX in an experimental model of EIU in rabbits. The results of our study demonstrated that intravitreal administration ...
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Intra-vitreal injection of methotrexate in experimental endotoxin-induced uveitis in rabbit
... Histopathological evaluations. On the seventh post intra-vitreal injection day, the rabbits were euthanized by an intra-cardiac injected overdose of sodium pento- barbital. The eyes were enucleated immediately after ...
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CD28 independent induction of experimental autoimmune encephalomyelitis
... CD28KO mice develop EAE after a booster immunization. Immunization followed by a second round of immu- nization on day 14 induced disease in CD28KO mice that was indistinguishable from the disease in WT mice except for ...
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The Effect of Aqueous Extract of Tarragon on Clinical Symptoms and T Cell Differentiation in Experimental Autoimmune Encephalomyelitis
... 5 Experimental autoimmune encephalomyelitis (EAE) has been widely used among various animal models to understand the immunopathology of ...the autoimmune disease by inhibition of the activity of ...
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T-cell recognition in experimental autoimmune thyroiditis
... on removal of one lobe of the thyroid of these rats which had the effect of decreasing thyroglobulin reserves and stimulating TSH levels, iodide supplementation increased the levels of thyroid infiltration from 13% to ...
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Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis
... Nevertheless, experimental inhibition of VEGF signalling using another neutralizing antibody decreased angiogenesis and astroglial proliferation, but led to greater neurodegeneration in a model of stab wound ...
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Proteasome inhibitors as experimental therapeutics of autoimmune diseases
... of autoimmune dis- eases is still at an early ...with autoimmune diseases such as SLE and refractory autoimmune hemolytic anemia (chronic cold agglutinin disease) where beneficial effects of BTZ were ...
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Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013
... of uveitis and AS were not clinically confirmed individually according to strict classification criteria, and overestimation or underestimation of the presence of diseases could have ...a uveitis episode ...
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