experimental cerebral malaria
REVIEW ARTICLE Changes in brain metabolites in experimental cerebral malaria infection with plasmodium berghei ANKA: A literature review
... human cerebral malaria, ECM= experimental cerebral malaria, NCM= non-cerebral malaria, PbA= Plasmodium berghei ANKA, CT= computerized tomography, MRI= magnetic resonance ...
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Glucagon like peptide 1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria
... 3 Cerebral CREB, cAMP and nitrate/nitrite levels in Plasmodium berghei ...the experimental cerebral malaria (ECM) model and Balb/c mice for non-cerebral malaria (NCM) ...
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Increased Survival in B Cell Deficient Mice during Experimental Cerebral Malaria Suggests a Role for Circulating Immune Complexes
... of malaria, an insect-borne disease that takes millions of lives every year, is still not fully under- ...causes cerebral ma- laria in ...an experimental model of cerebral ...of ...
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Efficacy of intranasal administration of artesunate in experimental cerebral malaria
... of experimental cerebral malaria was demonstrated, providing the first evidence that malaria-infected erythro- cytes use OLF as a gateway to the brain ...therapeutic cerebral ...
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Targeting the IL33 NLRP3 axis improves therapy for experimental cerebral malaria
... murine experimental cerebral malaria (ECM) (10) where anti-malarial drug treatment of established ECM leads to sub-optimal recovery, associated with significant mor- tality and development of severe ...
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Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase
... in malaria parasites via two routes: (i) from phosphoenolpyruvate (PEP) by phosphoenolpyruvate carboxylase (PEPC) in the cytosol, or (ii) from fumarate by consecutive reactions catalyzed by fumarate hydratase (FH) ...
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S1P Is Associated with Protection in Human and Experimental Cerebral Malaria
... A recent publication implicates the S1P pathway in life-threatening infectious disease processes (65). The authors re- port that in an LPS model of sepsis in mice, knockdown of Sphk1 through the use of small interfering ...
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Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
... Uninfected mice and infected mice that were treated with rapa- mycin beginning on day 4 p.i. or left untreated were sacrificed on day 6 p.i., and their brains were removed for histological exami- nation. Brain sections ...
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Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria
... in cerebral pathology, as the same significant changes were not observed in NCM mice ...the malaria pathway, miR-146a suppresses the CD40L, CXCL8, IFNγ, TLR2, TLR4, and ITGβ2 ...
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Original Article Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria
... of cerebral malaria (CM) are still incompletely un- derstood but, clearly, cerebral complications may result from concomitant microvessel obstruction and ...Since experimental CM is associ- ...
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Further evidence for an anti inflammatory role of artesunate in experimental cerebral malaria
... Cerebral malaria (CM) is a potentially reversible, diffuse encephalopathy characterized mainly by the presence of asexual forms of Plasmodium falciparum parasites in the peripheral blood smears, and altered ...
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Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study
... Sequestered leukocytes are recognized to be causally related to the pathogenesis of murine CM. The onset of neurological signs and symptoms is paralleled by the sequestration of CD8+ T-lymphocytes in the brain, and ...
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Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
... All experimental proce- dures were reviewed and approved by the Morehouse School of Medicine Institutional Animal Care and Use Committee (Permit Number ...experiment. Experimental groups of mice were ...
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The contribution of Natural Killer Complex loci to the development of experimental cerebral malaria
... Although initially CD1d-restricted NKT cells appeared to be an important NKC receptor expressing cell lineage responsible for the increase susceptibility to disease in malaria-infected BALB.B6- Cmv1 r mice [23], ...
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Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model
... to cerebral malaria protection in mice [44], and like the other biomarkers cited above, MIP1 β-CCL4 plays a role in the chemotaxis of immune cells in during infection ...
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Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria
... It has been reported that antioxidants act by reducing ROS activity and inhibiting lipid peroxidation induced by Plasmodium in membrane of parasitized erythro- cytes [48], suggesting that the observed anti-malarial ...
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Controlled release of artemisone for the treatment of experimental cerebral malaria
... anemic malaria (AM) related to high parasitemia, above 20%, one to two weeks later ...anemic malaria were also ...of malaria returned to a normal ...
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A quantitative brain map of experimental cerebral malaria pathology
... Although analyses using RT-PCR and luciferase-expressing parasites have shown that ECM is associated with accumulation of parasites in the brain [24, 37–39], the compartmentalisation of the pRBCs in the brain during ECM ...
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Bone marrow chimeric mice reveal a dual role for CD36 in Plasmodium berghei ANKA infection
... from experimental cerebral malaria ...for malaria intervention need to be cell- type specific, a requirement that cannot readily be met by present day technologies of drug ...
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Common PIEZO1 Allele in African Populations Causes RBCDehydration and Attenuates Plasmodium Infection
... of experimental cerebral malaria in the ...ated experimental cerebral malaria by measuring brain water content that reflects the severity of brain edema caused by ce- rebral ...
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