Experimental cerebral malaria (ECM)
REVIEW ARTICLE Changes in brain metabolites in experimental cerebral malaria infection with plasmodium berghei ANKA: A literature review
... human cerebral malaria, ECM= experimental cerebral malaria, NCM= non-cerebral malaria, PbA= Plasmodium berghei ANKA, CT= computerized tomography, MRI= magnetic ...
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Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling
... Human cerebral malaria (HCM) is a severe form of mal- aria characterized by sequestration of infected erythro- cytes (IRBCs) in brain microvessels, increased levels of circulating free heme and ...
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Suppression of experimental cerebral malaria by disruption of malate:quinone oxidoreductase
... in malaria parasites via two routes: (i) from phosphoenolpyruvate (PEP) by phosphoenolpyruvate carboxylase (PEPC) in the cytosol, or (ii) from fumarate by consecutive reactions catalyzed by fumarate hydratase (FH) ...
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Glucagon like peptide 1 analogue, liraglutide, in experimental cerebral malaria: implications for the role of oxidative stress in cerebral malaria
... against ECM [10, ...3 Cerebral CREB, cAMP and nitrate/nitrite levels in Plasmodium berghei ...the experimental cerebral malaria (ECM) model and Balb/c mice for ...
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Inhibiting the Mammalian Target of Rapamycin Blocks the Development of Experimental Cerebral Malaria
... with ECM or with IgG-specific anti- body to detect intraparenchymal IgG as a second measure of the loss of BBB integrity ...prevents experimental cerebral malaria ...
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Increased Survival in B Cell Deficient Mice during Experimental Cerebral Malaria Suggests a Role for Circulating Immune Complexes
... Combined data from four independent experiments are shown. (B) B-cell- deficient mice exhibit morphologically different vascular lesions in brains compared with those of wild-type mice in experimental ...
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Efficacy of intranasal administration of artesunate in experimental cerebral malaria
... of experimental cerebral malaria was demonstrated, providing the first evidence that malaria-infected erythro- cytes use OLF as a gateway to the brain ...therapeutic cerebral ...
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S1P Is Associated with Protection in Human and Experimental Cerebral Malaria
... A recent publication implicates the S1P pathway in life-threatening infectious disease processes (65). The authors re- port that in an LPS model of sepsis in mice, knockdown of Sphk1 through the use of small interfering ...
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The contribution of Natural Killer Complex loci to the development of experimental cerebral malaria
... of ECM including, upregulation of receptors mediating parasite sequestration in the vascular endo- thelium, induction of CXCR3 chemokines responsible for the recruitment of T cells to the brain, etc ...
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Targeting the IL33 NLRP3 axis improves therapy for experimental cerebral malaria
... established ECM, we administered anti-malarial drugs alone or together with IL33 to Pb ANKA infected mice at the onset of neurological dysfunction ...of cerebral pathology, including: cerebrovascular pRBC ...
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A quantitative brain map of experimental cerebral malaria pathology
... during ECM by smearing the well-perfused brain tissue of mice infected with Pb ...during ECM is dependent, or co-dependent, on parasite strain intrinsic capacities to deform within, and/or cytoadhere to, ...
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Improvement of the efficacy of dihydroartemisinin with atorvastatin in an experimental cerebral malaria murine model
... but it seemed that the mice of the combination group did not die of CM, as the mice in the other groups did, but rather died of anaemia with high parasitaemia. As shown previously, AVA, like other statins, is not ...
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Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
... murine experimental CM (ECM) indicate an exaggerated activa- tion and dysregulation of host inflammatory processes including brain endothelial activation, and disruption of the BBB during the pathogenesis ...
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Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria
... America. Malaria accounts for millions of deaths and many more millions are at ...severe malaria is a neurological syndrome known as cer- ebral malaria (CM) [22–24], which predominantly affects ...
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Further evidence for an anti inflammatory role of artesunate in experimental cerebral malaria
... Cerebral malaria (CM) is a potentially reversible, diffuse encephalopathy characterized mainly by the presence of asexual forms of Plasmodium falciparum parasites in the peripheral blood smears, and altered ...
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Original Article Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria
... of malaria – we set out to compare the CM-susceptible (CM-S) mouse strain, CBA/CaH, and CM-resistant (CM-R) BALB/cA mice in terms of their brain microvessel morphology upon in- fection with ...
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Glatiramer acetate reduces the risk for experimental cerebral malaria: a pilot study
... GA, also known as copolymer 1, is a heterogeneous mix of polypeptides containing the four amino acids alanine, lysine, glutamic acid and tyrosine in definite ratios but with no uniform sequence with an average molecular ...
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Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria
... Results: The change in abundance of miRNA was studied following infection of CBA mice with Plasmodium berghei ANKA strain (causing experimental CM), and Plasmodium yoelii, which causes severe malaria ...
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Controlled release of artemisone for the treatment of experimental cerebral malaria
... Cerebral malaria is a major cause of malarial death and its treatment is complicated because of the detrimental role of the parasite and the deleterious immunopatho- logical ...
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Common PIEZO1 Allele in African Populations Causes RBCDehydration and Attenuates Plasmodium Infection
... either experimental cerebral malaria (including ataxia, convulsion, paralysis and/or coma) or se- vere anemia (immobility and pale blood color), 2% Evans Blue (Sigma-Aldrich, dissolved in sterile ...
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