The Expression of p53 and p21 within Rafted W12 Cells
Expression of p53 and p21 in bladder carcinoma of Iraqi patients
... that p21 over-expression of p53 in relation to stage and grade was ...abnormal p21 expression, some of which were stages Ta and T1, but the majority were stage T2 or ...altered ...
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Expression of p21(WAF1/CIP1/SDI1) and p53 in apoptotic cells in the adrenal cortex and induction by ischemia/reperfusion injury
... of p21 as a key element in the cascade of events initiated by DNA damage and other forms of cellular injury has been elucidated mainly from experiments on cells in cul- ...nuclear p53 (16, 20), and ...
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The gene expression level of p53 and p21 in mouse brain exposed to radiofrequency field
... hippocampal expression of p21 and p53 genes as regulators of cellular ...hippocampal expression of p21and p53 mRNAs were evaluated using Real-Time ...mean expression level of ...
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Hepatitis C Virus NS5A Physically Associates with p53 and Regulates p21/waf1 Gene Expression in a p53-Dependent Manner
... the p21/waf1 promoter, a downstream effector gene of ...of p21/waf1. We observed that transcriptional repression of the p21/waf1 gene by NS5A is p53 dependent by using p53 wild-type ( ⴙ ...
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c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression
... same cells deficient in p21 expression not only delayed their acquisition of senescent phenotypes, but also partially restored their tumorigenicity in ...4T1 cells lacked detectable ...
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Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma
... Statistical analysis Statistical analysis was performed to determine the rela- tionship between the clinical parameters of gender, age, tumor size, number of tumors, hepatitis B surface antigen (HBsAg), pathologic grade, ...
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p21 WAF1/CIP1 expression in stage I cutaneous malignant melanoma: its relationship with p53, cell proliferation and survival
... The expression of p21, p53 and proliferating cell nuclear antigen (PCNA) was analysed by immunohistochemistry in a consecutive series of 369 clinical stage I cutaneous malignant melanoma ...detected ...
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Analysis of polymorphisms, promoter methylation, and mRNA expression profile of maternal and placental P53 and P21 genes in preeclamptic and normotensive pregnant women
... syncytiotrophoblast cells and necro- sis ...[9]. P53 protein, as a major transcription factor, is involved in the regulation of cell apoptosis, growth arrest, and DNA repair under cell stress condi- ...
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Original Article Over-expression of p53, p21 and Cdc2 in histologically negative surgical margins is correlated with local recurrence of laryngeal squamous cell carcinoma
... p21 expression was heterogeneous in various tumors, so that it is still controversial that p21 is a tumor suppressor gene or an ...when p21 was answering a variety of environmental stimuli, ...
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Immunohistochemical expression of p53 and p21 in gliomas: a clinicopathological study
... human p53 antibody (clone Do7, code M7001, Dako Denmark) and anti human p21 antibody (Clone SX118, code M7202, Dako ...strongly p53-positive breast carcinoma and a non proliferative compartment of ...
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cells is mediated by a p53-independent ILF3/p21 pathway
... harboring p53 mutations are invariably refractory to therapies based on purine analogues and have limited treatment options and poor ...in p53 wild-type B-CLL cells, the aim of this study was to ...
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Trichostatin A promotes GLI1 degradation and P21 expression in multiple myeloma cells
... TSA-induced p21 upregulation contributed to the reduced transcription of ...of p53 via acetylation, thereby enhancing the expression of p53 downstream genes such as ...overexpressing ...
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Synergistic anticancer effect of combined crocetin and cisplatin on KYSE-150 cells via p53/p21 pathway
... the p53/p21 pathway and induction of the mitochondria-mediated apoptosis pathway, as shown by the disruption of ...Bcl-2 expression and increased cleaved caspase-3 ...modulate p53/p21 ...
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Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1
... of cells at the G1 ...nuclear expression of p27Kip1 decreases with malignancy in human astrocytic gliomas and that p27Kip1 has an inde- pendent prognostic value in patients who have malig- nant glioma ...
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Inhibition of HIV early replication by the p53 and its downstream gene p21
... HCT116 p53 +/+ cells in comparison to HCT116 p53 − / − ...both p53 and p21 expressions were upregulated in non-cycling HCT116 p53 +/+ cells and HIV-1 reverse transcription ...
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A Human Herpesvirus MicroRNA Inhibits p21 Expression and Attenuates p21-Mediated Cell Cycle Arrest
... represses p21 in PEL cells, sponge-expressing BC-3 cell lines were plated at equal densi- ties and, 24 h later, treated with ...excessive p53-induced apoptosis during these experiments. The ...
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Original Article Epirubicin inhibits proliferation of breast cancer cells through upregulating p21 cip1 expression
... gene expression either through their inherent HAT activity or through its ability to interact with other coactivators and compo- nents of the basal transcriptional machinery ...gene expression could result ...
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Original Article Sulforaphane enhances cisplatin sensitivity in human osteosarcoma cells through upregulation of p53-p21 pathway by enhancing G1 arrest
... including p53, p27, p21, Bax, cyclin D and cyclin E mRNA (Figure 5A) and protein expressions (Figure 5B) were examined by qPCR and western blot analysis, respectively, in OS-732 ...increased p53, ...
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Exogenous p53 and ASPP2 expression enhances rAdV-TK/ GCV-induced death in hepatocellular carcinoma cells lacking functional p53
... on p53 status in hepatocellular carcinoma (HCC) ...TK, p53, and ASPP2 were overexpressed individually and in combination in Hep3B (p53 null) and HepG2 (p53 wild-type) cell lines and in primary ...
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p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression
... potential p53 defense mechanism, detrimental to viruses requiring cell division for infection, is cell cycle ...canonical p53 target genes Bax, a central regulatory factor of the apoptotic pathway, and ...
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